Anti-inflammatory effects of Brassica oleracea Var. capitata L. (Cabbage) methanol extract in mice with contact dermatitis

Abstract

Background:Cabbage, Brassica oleracea var. capitata L., is one of the most common vegetables in the world. Because of its high levels of flavonoids and anthocyanins, cabbage has long been used as a herbal medicine. The antioxidant and anti-inflammatory properties of cabbage were also recently been reported.Objective:This study was designed to investigate the anti-inflammatory effects of cabbage in mice with contact dermatitis (CD).Materials and Methods:We investigated the effects of methanol extract of B. oleracea var. capitata L. (MEBO) on ear swelling, erythema, and histopathological changes in CD mice. Moreover, the effects on cytokine production and the spleen/body weight ratio were investigated.Results:Topical treatment with MEBO inhibited ear swelling and erythema significantly. MEBO also significantly inhibited epidermal hyperplasia and infiltration of immune cells. Furthermore, the levels of tumor necrosis factor-alpha, interferon-gamma, interleukin-6, and monocyte chemotactic protein-1 in inflamed tissues were effectively lowered by MEBO. Finally, MEBO did not affect body weight gain or spleen body weight ratio.Conclusions:These results indicate that cabbage can be used for the treatment of skin inflammation and that its anti-inflammatory activity is closely related to the inhibition of Th1 skewing reactions.SUMMARY MEBO inhibited ear thickness, weight, and erythema in inflamed skinMEBO also prevented epidermal hyperplasia and infiltration of immune cellsThe levels of tumor necrosis factor-α, interferon-γ, interleukin-6, and monocyte chemotactic protein-1 in inflamed tissues were lowered by MEBO. Abbreviations used: AOO: Acetone and olive oil (4:1), CBA: Cytometric bead array, CD: Contact dermatitis, DEX: Dexamethasone, DNFB: 1-fluoro-2,4-dinitrofluorobenzene, GM-CSF: Granulocyte-macrophage colony-stimulating factor, ICAM-1: Intercellular Adhesion Molecule-1, LPS: Lipopolysaccharide, MEBO: Methanol extract of Brassica oleracea, MCP-1: Monocyte chemotactic protein-1, NO: Nitric oxide.

Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells

“…Although there have not been many studies investigating the biological functions of plant-derived nanovesicles, a number of studies have reported the anti-inflammatory activities of components extracted from plants using organic solvents [ [44] , [45] , [46] ]. To investigate the anti-inflammatory activities of Cabex and Rabex, RAW264.7 cells were supplemented with 0, 1 × 10 8 , 1 × 10 9 , 1 × 10 10 , and 1 × 10 11 particles mL −1 of nanovesicles and treated with LPS to induce inflammation [ 47 , 48 ].…”

Study of the antiulcer activity of dry extract of garden cabbage on a model of subchronic gastric ulcer

“…The garden cabbage (Brassica oleracea L.) is widely used worldwide as a vegetable crop, traditional medicine has used it in the treatment of various diseases, including the gastrointestinal tract. Scientific publications in recent years have demonstrated the presence of cabbage pharmacological properties caused by the complex of biologically active compounds in its composition, which was the justification an experimental study of the dry extract produced from cabbage garden [8][9][10].…”

Investigação Do Conhecimento Tradicional E Científico De Plantas Alimentícias Em Juazeiro Do Norte-Ce-Bra

“…23 Apesar de não ter sido encontrada, na literatura consultada, atividade contra inflamações uterinas, há indícios de atividade anti-inflamatória em diferentes variedades de Brassica. 24 A goiaba pertence ao gênero Psidium e é uma planta alimentícia muito comum no Nordeste brasileiro. A utilização contra diarreia é muito citada na literatura provavelmente devido ao conteúdo em taninos que possuem atividades antimicrobianas e adstringentes.…”