Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice

Kang, Tong Ho; Park, Hye Min; Kim, Yoon-Bum; Kim, Hyunae; Kim, Nami; Do, Jae-Ho; Kang, Chulhun; Cho, Yunhi; Kim, Sun Yeou

doi:10.1016/j.jep.2009.03.022

Cited by 121 publications

(73 citation statements)

References 26 publications

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“…28 The change in Runx-2 gene expression level among samples directly relates to the observed change of OCN expression, since Runx-2 can directly stimulate transcription of OCN-the most abundant nano collagenous protein in bone ECM. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] The up-regulation of OCN during matrix synthesis and mineralization, 27 is curtail for later stages of osteogenesis and ECM mineral formation. The obtained gene expression profile for MSCs seeded on PCL group was in agreement with other studies.…”

Section: Mscs Proliferation and Differentiation On Electrospun Scaffoldsmentioning

confidence: 99%

“…33 However, despite the various reported medicinal applications of the ginseng extract, no studies have yet reported the potential effect of Panax ginseng extract on bioactivity of the bone tissue engineering scaffolds. In this study nanocomposites of PCL and ginsenoside (the major component of ginseng 9 ) was fabricated by electrospinning technique and the physical and mechanical properties of electrospun nanofibers as well as their biocompatibility were evaluated. Furthermore, the osteogenic differentiation of rabbit mesenchymal stem cells (MSCs) seeded on fabricated bio-composite scaffolds was evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Physical and Biological Modification of Polycaprolactone Electrospun Nanofiber by Panax Ginseng Extract for Bone Tissue Engineering Application

2015

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Medicinal plants as a therapeutic agent with osteogenic properties can enhance fracture-healing process. In this study, the osteo-inductive potential of Asian Panax Ginseng root extract within electrospun polycaprolactone (PCL) based nanofibers has been investigated. Scanning electron microscopy images revealed that all nanofibers were highly porous and beadles with average diameter ranging from 250 to 650 nm. The incorporation of ginseng extract improved the physical characteristics (i.e., hydrophilicity) of PCL nanofibers, as well as the mechanical properties. Although ginseng extract increased the degradation rate of pure PCL nanofibers, the porous structure and morphology of fibers did not change significantly after 42 days. It was found that nanofibrous scaffolds containing ginseng extract had higher proliferation (up to ~1.5 fold) compared to the pristine PCL. The qRT-PCR analysis demonstrated the addition of ginseng extract into PCL nanofibers induced significant expression of osteogenic genes (Osteocalcin, Runx-2 and Col-1) in MSCs in a concentration dependent manner. Moreover, higher calcium content, alkaline phosphatase activity and higher mineralization of MSCs were observed compared to the pristine PCL fibers. Our results indicated the promising potential of ginseng extract as an additive to enhance osteo-inductivity, mechanical and physical properties of PCL nanofibers for bone tissue engineering application.

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Section: Mscs Proliferation and Differentiation On Electrospun Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical and Biological Modification of Polycaprolactone Electrospun Nanofiber by Panax Ginseng Extract for Bone Tissue Engineering Application

2015

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“…It was suggested that the anti-apoptotic effects of Rb1 on UV-treated cells is due to the induction of the body's DNA repair system, most likely through nucleotide excision repair (NER). Meanwhile, the antiaging effects of Korean red ginseng in skin were demonstrated using replica analysis in a mouse model [26]. In this study, the animal diet was supplemented with 2.5 % red ginseng extract, which reduced wrinkle formation induced by UVB.…”

Section: Biological Activitiesmentioning

confidence: 98%

“…Simultaneously, decreased matrix metalloproteinase-1 (MMP-1) expression and increased type I procollagen levels were observed in the group supplemented with 2.5 % red ginseng, which may have contributed to the antiwrinkle formation effect. Interestingly, Rb1 is the most abundant compound in Korean red ginseng, at 43.5 mg/g of extract [26].…”

Section: Biological Activitiesmentioning

confidence: 99%

Ginsenosides and their metabolites: a review of their pharmacological activities in the skin

et al. 2015

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Ginsenosides are representative pharmaceutical compounds found in various forms in Panax ginseng, a traditional medicinal plant. They are converted to their metabolites Rg2, Rg3, compound K, and others by human intestinal microflora following ingestion. Numerous studies have demonstrated beneficial effects of ginsenosides against aberrant molecular processes responsible for cancer, metabolic diseases and neurodegenerative diseases. Recently, antiaging effects of ginsenosides in human skin have been reported from clinical trial and in vitro model data. Ginsenosides have hence been proposed as promising natural cosmeceutical agents. In this review, we will critically review the known biological effects of several ginsenosides (Rb1, Rg3, Rd and compound K), such as anti-inflammatory and anticancer activities, which arise from the modulation of diverse molecular pathways. The application potential of ginsenosides as cosmeceutical ingredients will also be reviewed.

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“…Ginsenoside is one of the components of Korean ginseng and prevents chronic ultraviolet (UV)-B-induced skin photoaging. 4,5) It is possible that the administration of extracts of E. ulmoides leaves and Korean ginseng can improve damaged skin. Aging of skin due to UV exposure is called photoaging.…”

mentioning

confidence: 99%

Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice

Jimbo

Kawada

Nomura

2015

Bioscience, Biotechnology, and Biochemistry

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We examined the effect of the daily ingestion of herb extract from Eucommia ulmoides leaves and Korean ginseng on skin damage induced by repeated UV irradiation of hairless mice. The herb extract was orally administered to mice at a dose of 1000 mg/kg/day. The hydration of mice dorsal skin decreased significantly with repeated UV irradiation, but did not decrease when the herb extract was administered for seven weeks. Transepidermal water loss (TEWL) increased with UV irradiation, but decreased with the administration of dietary herb extract. These effects were more pronounced when combined with the administration of collagen hydrolysate. Geniposidic acid from E. ulmoides leaves and ginsenoside Rg1 from Korean ginseng reduced TEWL and increased the skin moisture content of UV-damaged skin on hairless mice, respectively. We concluded that this dietary herb extract reduced the skin damage caused by UV-induced aging, with geniposidic acid and ginsenoside Rg1 detected in the blood.

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Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice

Cited by 121 publications

References 26 publications

Physical and Biological Modification of Polycaprolactone Electrospun Nanofiber by Panax Ginseng Extract for Bone Tissue Engineering Application

Physical and Biological Modification of Polycaprolactone Electrospun Nanofiber by Panax Ginseng Extract for Bone Tissue Engineering Application

Ginsenosides and their metabolites: a review of their pharmacological activities in the skin

Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice

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