Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice

Abstract

We examined the effect of the daily ingestion of herb extract from Eucommia ulmoides leaves and Korean ginseng on skin damage induced by repeated UV irradiation of hairless mice. The herb extract was orally administered to mice at a dose of 1000 mg/kg/day. The hydration of mice dorsal skin decreased significantly with repeated UV irradiation, but did not decrease when the herb extract was administered for seven weeks. Transepidermal water loss (TEWL) increased with UV irradiation, but decreased with the administration of dietary herb extract. These effects were more pronounced when combined with the administration of collagen hydrolysate. Geniposidic acid from E. ulmoides leaves and ginsenoside Rg1 from Korean ginseng reduced TEWL and increased the skin moisture content of UV-damaged skin on hairless mice, respectively. We concluded that this dietary herb extract reduced the skin damage caused by UV-induced aging, with geniposidic acid and ginsenoside Rg1 detected in the blood.

Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

“…On the last day of the experiment, TEWL and skin hydration were determined with a Tewameter TM300 and Corneometer CM 825 (Courage and Khazaka, Cologne, Germany), respectively, applied to the dorsal skin under controlled conditions of 21–22°C and 50–55% humidity. 47 The probe was placed on the skin and stabilized for approximately 30 s, and then the measurement was recorded. This measurement procedure was repeated five times in the same area at the same pressure.…”

Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis

“…Total dermatitis scores for mice were calculated with the maximal score of 12. Prior to sacrifice, transepidermal water loss (TEWL), representing the volume of water emitted from the body to the atmosphere through the epidermal layer (skin) by diffusion and evaporation, was measured using a Tewameter TM300 (Courage and Khazaka, Cologene, Germany) at 21–22°C and 50–55% humidity as described previously (Jimbo et al, 2015). The probe was located on the skin for 30 s and the data were measured.…”

Bibliometric analysis of the effects of ginseng on skin

“…Ginseng has good anti‐aging and wrinkle‐reducing effects. With regard to the process of skin photoaging caused by ultraviolet rays, various active substances in ginseng have inhibitory effects on keratinocyte apoptosis caused by ultraviolet rays and can reduce the resulting skin damage, reduce transdermal water loss and increase skin moisture content 13 …”

“…With regard to the process of skin photoaging caused by ultraviolet rays, various active substances in ginseng have inhibitory effects on keratinocyte apoptosis caused by ultraviolet rays and can reduce the resulting skin damage, reduce transdermal water loss and increase skin moisture content. 13 In addition to the anti-aging effects of ginseng, there have been many studies on its whitening effects. Studies 14 hibiting the activity of tyrosinase or blocking the melanin-producing oxidation pathway involving tyrosine to achieve a whitening effect.…”