Effects of Omega-3 Fatty Acids on Serum Lipids, Lipoprotein (a), and Hematologic Factors in Hemodialysis Patients

Kooshki, Akram; Taleban, Forough Azam; Tabibi, Hadi; Hedayati, Mehdi

doi:10.3109/0886022x.2011.605536

Cited by 38 publications

(46 citation statements)

References 32 publications

(47 reference statements)

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“…There are no similar or comparable reports in dogs in the literature. In humans, there are reports of haemoglobin reduction in healthy individuals [96] and no change in patients with risk of anaemia after supplementation with fish oil [97, 98]. Likewise, we observed a significant reduction of the MCV values within the fish oil group, but comparable changes in dogs were not found elsewhere; also, no statistical difference was observed between groups.…”

Section: Discussionsupporting

confidence: 75%

“…Likewise, we observed a significant reduction of the MCV values within the fish oil group, but comparable changes in dogs were not found elsewhere; also, no statistical difference was observed between groups. Elevations in packed cell volume after ingestion of fish oil for six weeks have been reported in healthy human beings [96], and no difference were found in patients with risk of anaemia [97]. The leucocyte counts of dogs in the present study revealed a significant reduction in the number of monocytes and basophils in the group receiving fish oil, from baseline to the end of the trial.…”

Section: Discussionsupporting

confidence: 47%

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Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil

et al. 2016

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BackgroundOxidative stress plays an important role in the pathogenesis of disease, and the antioxidant physiological effect of omega-3 from fish oil may lead to improvement of canine spontaneous osteoarthritis (OA).MethodsIn this prospective randomized, controlled, double-blinded study, we assessed haematological and biochemical parameters in dogs with OA following supplementation with either a concentrated omega-3 deep sea fish oil product or corn oil. Blood samples from 77 client-owned dogs diagnosed as having OA were taken before (baseline) and 16 weeks after having orally ingested 0.2 ml/Kg bodyweight/day of deep sea fish oil or corn oil. Circulating malondialdehyde (MDA), glutathione (GSH), non-transferrin bound iron (NTBI), free carnitine (Free-Car), 8-hydroxy-2-deoxyguanosine (8-OH-dG), and serum fatty acids, haemograms and serum biochemistry were evaluated. Differences within and between groups from baseline to end, were analysed using repeated samples T-test or Wilcoxon rank test and independent samples T-test or a Mann-Whitney test.ResultsSupplementation with fish oil resulted in a significant reduction from day 0 to day 112 in MDA (from 3.41 ± 1.34 to 2.43 ± 0.92 μmol/L; P < 0.001) and an elevation in Free-Car (from 18.18 ± 9.78 to 21.19 ± 9.58 μmol/L; P = 0.004) concentrations, whereas dogs receiving corn oil presented a reduction in MDA (from 3.41 ± 1.34 to 2.41 ± 1.01 μmol/L; P = 0.001) and NTBI (from −1.25 ± 2.17 to −2.31 ± 1.64 μmol/L; P = 0.002). Both groups showed increased (albeit not significantly) GSH and 8-OH-dG blood values. Dogs supplemented with fish oil had a significant reduction in the proportions of monocytes (from 3.84 ± 2.50 to 1.77 ± 1.92 %; P = 0.030) and basophils (from 1.47 ± 1.22 to 0.62 ± 0.62 %; P = 0.012), whereas a significant reduction in platelets counts (from 316.13 ± 93.83 to 288.41 ± 101.68 × 109/L; P = 0.029), and an elevation in glucose (from 5.18 ± 0.37 to 5.32 ± 0.47 mmol/L; P = 0.041) and cholesterol (from 7.13 ± 1.62 to 7.73 ± 2.03 mmol/L; P = 0.011) measurements were observed in dogs receiving corn oil.ConclusionsIn canine OA, supplementation with deep sea fish oil improved diverse markers of oxidative status in the dogs studied. As corn oil also contributed to the reduction in certain oxidative markers, albeit to a lesser degree, there was no clear difference between the two oil groups. No clinical, haematological or biochemical evidence of side effects emerged related to supplementation of either oil. Although a shift in blood fatty acid values was apparent due to the type of nutraceutical product given to the dogs, corn oil seems not to be a good placebo.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 47%

Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil

et al. 2016

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“…Clinical studies have demonstrated that DHA supplementation has no effect on iron absorption [28,32] that is in agreement with the results of the current study.…”

Section: Discussionsupporting

confidence: 93%

“…Fasting serum ferritin was measured by chemiluminescent immunoassay (CLIA, Liaison, DiaSorin, Italy); serum ApoA-I and ApoB were measured by turbidimetry (Cobas Integra 400, Roche Diagnostics, Mannheim, Germany) [28]; serum iron was measured by spectrophotometer based on the reaction of iron with ferene reagent at acidic conditions, and hs-CRP was measured by immunofluorescence (Vitros Chemistry Products, Johnson & Johnson Clinical Diagnostics, Rochester, USA) [29]. Paraoxonase-1 was measured by spectrophotometry [30].…”

Section: Outcome Measuresmentioning

confidence: 99%

Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia

Shidfar

Amani

Vafa

et al. 2015

Biol Trace Elem Res

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Numerous studies have demonstrated that tissue deposition of iron following prolonged high dose of oral supplementation for treatment of iron deficiency anemia (IDA) leads to body iron overload and oxidative stress, which starts the process of atherosclerosis. This study aimed to determine the effect of iron supplementation in combination with docosahexaenoic acid (DHA) on the cardiovascular disease risk based on paraoxonase-1 (PON-1), high-sensitivity C-reactive protein (hs-CRP), and ApoB/ApoA-I ratio in women with IDA. In this randomized controlled trial, 76 women with IDA, aged 15-45 years, were included. The patients were randomly assigned to receive 500 mg of DHA supplement or placebo with an iron tablet, once daily for 12 weeks. The participants were assessed by measurement of the serum iron, ferritin, PON-1, hs-CRP levels, and the ApoB/ApoA-I ratio at the beginning and end of study. Serum hs-CRP decreased in the DHA-supplemented group (p = 0.036), and ApoA-I decreased in the placebo group (p = 0.013). No significant difference was detected for the serum PON-1 concentration and the ApoB/ApoA-I ratio in two groups. Iron supplementation combined with DHA may have favorable effects on serum hs-CRP in women with IDA.

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“…45% irrespective of the plasma concentration of Lp(a) [111]. This is in agreement with many other studies showing that fish oils only seem to be able to reduce Lp(a) in combination with other therapies [107] or moderate exercise [112] but not when used alone [113,114,115].…”

Section: Lp(a) and Lipid Lowering Drugssupporting

confidence: 80%

Lipoprotein (a) – An Overview

Gries¹

2012

Lipoproteins - Role in Health and Diseases

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Effects of Omega-3 Fatty Acids on Serum Lipids, Lipoprotein (a), and Hematologic Factors in Hemodialysis Patients

Abstract: Background: Lipid abnormalities, especially high serum lipoprotein (a) [Lp (a)] concentration, and anemia are two major causes of cardiovascular diseases (CVDs)

Cited by 38 publications

References 32 publications

Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil

Evaluating oxidative stress, serological- and haematological status of dogs suffering from osteoarthritis, after supplementing their diet with fish or corn oil

Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia

Lipoprotein (a) – An Overview

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