Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia

Shidfar, Farzad; Amani, Samira; Vafa, Mohammadreza; Shekarriz, Ramin; Hosseini, Seyyed Hossein; Shidfar, Shahrzad; Eshraghian, M R; Mousavi, Seyedeh Neda

doi:10.1007/s12011-015-0383-7

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…In that study, Burillo et al reported that the supplement increased PON1 protein, thereby suggesting a positive change in the functionality of the HDL molecule [86]. Contrary to these findings, in a randomized controlled trial, women with iron deficiency anemia randomly assigned to receive 500 mg of DHA supplement or placebo with an iron tablet, once daily for 12 weeks, showed no significant differences in terms of serum PON1 concentration [87]. Four years ago, Whelan et al reviewed the effect of stearidonic acid, a highly unsaturated (n-3) PUFA that is effectively metabolized to eicopentaenoic acid, and concluded that its administration is a favorable modulator of PON1 [88].…”

Section: Dietary Lipidsmentioning

confidence: 99%

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Lou-Bonafonte

Gabás‐Rivera

Navarro

et al. 2017

IJMS

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Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments.

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Section: Dietary Lipidsmentioning

confidence: 99%

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Lou-Bonafonte

Gabás‐Rivera

Navarro

et al. 2017

IJMS

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“…Understanding the role of specific nutrients during inflammation and the body's response to dietary nutrient absorption in healthy, nutrient‐deprived, or inflamed conditions is essential for developing strategies to increase bioavailability of dietary nutrients in non‐communicable diseases through dietary means. In this paper, we explore the nutrient‐dependent acute immune response, with a focus on nutrients linked to inflammation and supported by double‐blind placebo‐controlled trials, such as iron, 30,31 vitamins A, 32 C, 33 and other antioxidants such as polyphenols 34…”

Section: Introductionmentioning

confidence: 99%

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Roth‐Walter,

Berni Canani,

O'Mahony

et al. 2023

Allergy

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Nutritional Immunity is one of the most ancient innate immune responses, during which the body can restrict nutrients availability to pathogens and restricts their uptake by the gut mucosa (mucosal block). Though this can be a beneficial strategy during infection, it also is associated with non‐communicable diseases—where the pathogen is missing; leading to increased morbidity and mortality as micronutritional uptake and distribution in the body is hindered. Here, we discuss the acute immune response in respect to nutrients, the opposing nutritional demands of regulatory and inflammatory cells and particularly focus on some nutrients linked with inflammation such as iron, vitamins A, Bs, C, and other antioxidants. We propose that while the absorption of certain micronutrients is hindered during inflammation, the dietary lymph path remains available. As such, several clinical trials investigated the role of the lymphatic system during protein absorption, following a ketogenic diet and an increased intake of antioxidants, vitamins, and minerals, in reducing inflammation and ameliorating disease.

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Paraoxonases: metabolic role and pharmacological projection

Moya

Máñez

2018

Naunyn-Schmiedeberg's Arch Pharmacol

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Atherosclerosis is one of the leading causes of death in Western countries, with high-density lipoproteins (HDL) playing an important protective role due to their ability to inhibit oxidation of low-density lipoproteins (LDL), thus relieving vascular subendothelial damage. One of the proteins constituting HDL particles is paraoxonase-1 (PON1), an enzyme able to hydrolyze aryl esters, lactones, and organophosphates. Other closely related paraoxonases are designated as PON2, which is a protein localized inside many different kinds of cells, and PON3, not only present in HDL but also in mitochondria and endoplasmic reticulum, as well. Given that the amount and the activity of PON1 in human serum are significantly lower in people suffering from cardiovascular diseases, enhancing both parameters might contribute to their treatment and prevention. One of the physiologically interesting substrates for the abovementioned hydrolytic cleavage is homocysteine thiolactone (HTL), an atherothrombotic active form of homocysteine. Although it was therefore postulated that PON1 would participate in preventing the HTL-mediated lipid peroxidation, some attention is recently paid to other enzymes, like biphenyl hydrolase-like protein, that seem to more selectively involved in lowering this risk factor. The aim of this paper is to elucidate the role of paraoxonases, especially PON1, by reviewing the latest studies in order to understand both its physiological role and modulation by drugs, nutrients, and plant extracts.

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Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia

Cited by 7 publications

References 36 publications

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Paraoxonases: metabolic role and pharmacological projection

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