Effects of Nigella sativa oil on Th1/Th2, cytokine balance, and improvement of asthma control in children

Barlıanto, Wisnu; Rachmawati, Maria; Irawan, Muhammad Zudhy; Wulandari, Desy

doi:10.14238/pi57.5.2017.1399

Cited by 5 publications

(12 citation statements)

References 10 publications

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“…Three hundred and fifteen potentially relevant articles are identified initially. Finally, four RCTs are included in the meta-analysis [20][21][22][23].…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Han

Shi

2021

pdia

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A b s t r a c tIntroduction: The efficacy of Nigella sativa supplementation for asthma control remains controversial. We have conducted a systematic review and meta-analysis to explore the influence of Nigella sativa supplementation on asthma control. Material and methods: We have searched PubMed, EMBASE, Web of science, EBSCO, and Cochrane library databases through June 2019 for randomized controlled trials (RCTs) assessing the efficacy of Nigella sativa supplementation for asthma control. Results: Four RCTs are included in the meta-analysis. Overall, compared with the control group for asthma, Nigella sativa supplementation is associated with the increased ACT scores (SMD = 0.50; 95% CI: 0.11-0.88; p = 0.01), and FEV1 (SMD = 1.84; 95% CI: 0.07-3.60; p = 0.04), but demonstrates no obvious impact on PEF (SMD = 3.11; 95% CI: -1.30 to 7.52; p = 0.17), IL-4 (SMD = -0.31; 95% CI: -1.21 to 0.59; p = 0.50), or IFN-γ (SMD = 1.11; 95% CI: -0.44 to 2.67; p = 0.16).Conclusions: Nigella sativa supplementation may provide additional benefits for the treatment of asthma.

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“…Three hundred and fifteen potentially relevant articles are identified initially. Finally, four RCTs are included in the meta-analysis [20][21][22][23].…”

Section: Resultsmentioning

confidence: 99%

“…Current evidence is insufficient for routine clinical use of Nigella sativa supplementation in asthmatic patients. Recently, several studies have investigated the efficacy of Nigella sativa supplementation for these patients, but the results are conflicting [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Han

Shi

2021

pdia

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“…Serum levels of IFN- γ were significantly increased after 12 weeks of treatment with N. sativa compared to the baseline [ 127 ]. Treatment with soft gel capsules of N. sativa oil (15–30 mg/kg/day) significantly increased serum levels of IFN- γ and reduced serum levels of IL-4 in asthmatic children (aged 6–15) compared to control [ 137 ]. In one study, researchers showed that the oils of N. sativa (15–30 mg/kg) significantly decreased Th17 and also increased Treg percentages.…”

Section: Resultsmentioning

confidence: 99%

The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

Moghaddam

Kianmehr

Khazdair

2020

Evidence-Based Complementary and Alternative Medicine

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The use of plants or their isolated bioactive components for the prevention and treatment of various disorders has been developed. Here, we aim to identify effective medicinal plants for relief of cough and respiratory symptoms in children. The data of this review article were obtained from published articles in scientific databases, including PubMed, Google Scholar, and Scopus, until December 2019. The keywords, including “Zataria multiflora Boiss.” OR “Portulaca oleracea L.” OR “Ferula assa-foetida L.” OR “Nigella sativa L.” AND “respiratory symptoms” OR “airway inflammation” OR “smooth muscle relaxant effects,” were searched individually or combined. The mentioned medicinal plants decreased total white blood cell (WBC), neutrophils, and eosinophils counts of blood and lung lavage in animal model-induced respiratory disorders. These plants also have protective effects on serum immunoglobulin, antibody titer, eosinophil count, and proinflammatory cytokines. Evidence from the studies indicated that the abovementioned medicinal plants have smooth muscle relaxant properties (bronchodilator effects) via stimulation of β-adrenoceptor or inhibition of muscarinic receptors (in vitro) and also improved the pulmonary function test in clinical settings. These medicinal plants are safe and easy to use. Based on the anti-inflammatory, anti-antispasmodic, and immunomodulatory effects, the clinical benefit may be assumed, therefore considering a place for these medicinal plants in relieve of chronic cough and symptoms of children’s allergy, asthma, and common cold.

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“…In a study, treatment with N. sativa oil supplementation resulted in improvement on clinical and inflammatory parameters of asthma such as ACT score, pulmonary function test, blood eosinophils and total serum Immunoglobulin E [ 20 ]. Moreover, supplementation with N. sativa oil improves interferon-γ (IFN-γ)/IL-4 balance and ACT in children with asthma [ 21 ]. These studies suggest that N. sativa might improve the clinical outcome of a patient with asthma through the various pathways within the spectrum of asthma pathophysiology.…”

Section: Main Textmentioning

confidence: 99%

Nigella sativa as an anti-inflammatory agent in asthma

et al. 2018

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ObjectiveNigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The laboratory experiment was used to investigate the effectivity of N. sativa as an anti-inflammatory on mast cells. Six groups of mast cells were stimulated by C 48/80 to release histamine. Group 1 were without N. sativa, while group 2, 3, 4, 5, and 6 were given N. sativa with concentrations of 0.1 mg/ml, 0.2 mg/ml, 0.3 mg/ml, 0.4 mg/ml and 0.5 mg/ml, respectively. Histamine concentration was measured by high-performance liquid chromatography-fluorometry.ResultThe study showed that N. sativa ethanol extract effectively inhibit histamine release from peritoneal Wistar rat mast cells proportionally to its concentration. N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. N. sativa could be considered as a potential therapy for asthma therapy and prevention.

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Effects of Nigella sativa oil on Th1/Th2, cytokine balance, and improvement of asthma control in children

Cited by 5 publications

References 10 publications

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

Nigella sativa as an anti-inflammatory agent in asthma

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