The efficacy of Nigella sativa supplementation for asthma control: a meta-analysis of randomized controlled studies

Han, Anqiang; Shi, Danqin

doi:10.5114/ada.2020.93220

Cited by 1 publication

(8 citation statements)

References 33 publications

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“…Subsequently, 210 records were excluded after screening titles and abstracts. The full texts of 34 records were further evaluated, and 20 records (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) were eventually included in the analysis (Figure 1 shows the flow chart of study selection).…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…All meta-analyses were published in peer-reviewed journals between 2016 and 2022. These studies were conducted in seven regions: 13 from Iran ( 28 , 30 , 33 , 34 , 37 – 45 ), two from China ( 32 , 35 ), and one each from Australia ( 26 ), India ( 27 ), United Kingdom ( 29 ), the USA ( 31 ), and Indonesia ( 36 ). The number of RCTs ranged from three to 50, with 187–3,679 subjects.…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen studies reported doses of N. sativa , ranging from 0.5 to 6 g or 2.5 to 5 ml daily ( 26 – 30 , 32 – 45 ). Five studies reported the frequency of N. sativa administration, which varied between once, twice, and thrice a day ( 29 , 32 – 35 ). The treatment duration ranged from 2 weeks to 1 year.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies registered protocols on the PROSER platform ( 27 – 29 , 39 ) and one in the Cochrane library ( 31 ). In terms of the risk of bias tools, 10 studies used the Cochrane risk of bias tool ( 26 – 28 , 30 , 31 , 33 , 35 , 39 , 44 , 45 ), nine studies used the Jadad scale ( 32 , 34 , 36 – 38 , 40 – 43 ), and one used the standardized JBI critical appraisal checklist ( 29 ). Table 1 summarizes the basic characteristics of the included meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies have reported forms of N. sativa, including capsules, oils, and powders. Nineteen studies reported doses of N. sativa, ranging from 0.5 to 6 g or 2.5 to 5 ml daily (26)(27)(28)(29)(30)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). Five studies reported the frequency of N. sativa administration, which varied between once, twice, and thrice a day (29, [32][33][34][35].…”

Section: Basic Characteristics Of the Included Literaturementioning

confidence: 99%

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Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses

Wang

et al. 2023

Front. Nutr.

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BackgroundNigella sativa (N. sativa) consumption has been associated with various health outcomes; however, the results are not completely consistent.ObjectivesThis overview of systematic reviews and meta-analyses aimed to evaluate the reporting and methodological quality, and to grade the available evidence of associations between N. sativa and health outcomes.MethodsPubMed, Cochrane Library, Embase, and Scopus databases were searched from their inception to September 30, 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 statement, Assessment of Multiple Systematic Reviews (AMSTAR) 2 checklist, and Grades of Recommendations, Assessment, Development and Evaluations (GRADE) systems were used to assess the reporting, methodological, and evidence quality for each meta-analysis, respectively. The results were synthesized in a narrative form.ResultsThis overview included 20 eligible meta-analyses published in peer-reviewed journals between 2013 and 2021. The overall methodological quality was relatively poor, with only one moderate quality, four low quality, and 15 critically low quality studies. For reporting quality, items two, five, eight, nine, 15, and 24 need to improve. Among the 110 outcome indicators of the quality of evidence, five were graded as moderate, 17 as low, and 88 as very low. Risk of bias, inconsistency, and imprecision were the main downgrading factors.ConclusionThis overview suggests that N. sativa is beneficial for various clinical outcomes. However, there are certain limitations to reporting and methodological quality. The clinical efficacy of N. sativa requires confirmation in high-quality, large-sample, randomized controlled trials.

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