Effects of L-Ascorbic Acid and Alpha-Tocopherol on Biochemical Parameters of Swimming-Induced Oxidative Stress in Serum of Guinea Pigs

Bursać-Mitrović, Marija; Мilоvаnоvić, Drаgаn; Mitić, Radoslav; Jovanović, Danijela; Sovrlić, Miroslav; Vasiljević, Perica; Tomović, Jovica; Manojlović, N.

doi:10.21010/ajtcam.v13i4.5

Cited by 9 publications

(6 citation statements)

References 25 publications

(22 reference statements)

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“…In addition, the Ala variant of rs4880 SOD2 gene polymorphism, together with the diet rich in antioxidant substances, decrease DNA damage in healthy, young people despite high inter-individual variations in basal and oxidant-triggered responses (27). Other researchers also reported importance of essential nutrients for antioxidative defense system and body function in both experimental and clinical conditions (28,29). Finally, the augmentation of inflammatory signaling pathways could contribute to the effects of adverse, prooxidative state in the presence of SOD2 polymorphism rs4880.…”

Section: Discussionmentioning

confidence: 99%

Superoxide Dismutase 2 Val16Ala Polymorphism is Associated with Amiodarone-Associated Liver Injury

Radmanović

Jovanović

Djordjević

et al. 2022

Serbian Journal of Experimental and Clinical Research

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Association of SOD2 V16A single-nucleotide polymorphism (rs4880) with drug hepatotoxicity were reported but relationships with amiodarone prescriptions remained unexplored. Research was an exploratory, controlled prospective clinical trial. Patients hospitalized and treated in Clinical Center in Kragujevac, Serbia (in year 2017) were divided into experimental (using amiodarone, having liver injury, n=29, 19 males, the mean age 66.8±10.4 years), control A (neither amiodarone use nor hepatotoxicity, n=29, 19, 66.1±10.3) and control B group (using amiodarone, not having hepatotoxicity, n=29, 19, 66.8±9.8). From blood samples, among other routine biochemistry, genotyping for SOD2 polymorphism Val16Ala was conducted using real-time PCR method with TaqMan® Genotyping Master Mix and TaqMan® DME Genotyping Assay for rs4880. Patients taking amiodarone and having liver injury were mostly carriers of Val/Val (TT) genotype (13 of 24 patients, 54.2%) while Val/Ala (TC) and Ala/Ala (CC) genotypes prevailed in control group A (19 of 40, 47.5%) and control group B (9 of 23, 39.1%), respectively (2=10.409, p=0.034). Frequency of Val (T) and Ala (C) alleles were 0.51 and 0.49, respectively in the whole study sample (Hardy Weinberg equilibrium, 2=0.56, p=0.454). Carriers of TT genotype had significantly higher ALT (437.0±1158.0 vs 81.9131.5 U/L), total bilirubin (28.320.5 vs 15.313.0 mol/L) and total bile acid concentrations (10.910.2 vs 6.45.3 mol/L) compared to carriers of TC genotype (U=2.331, p=0.020, U=3.204, p=0.001 and U=2.172, p=0.030, respectively). Higher incidence of 47T allele of SOD2 was inpatients with amiodarone-associated liver injury as compared to patients on amiodarone not experiencing hepatotoxic effects.

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Section: Discussionmentioning

confidence: 99%

Superoxide Dismutase 2 Val16Ala Polymorphism is Associated with Amiodarone-Associated Liver Injury

Radmanović

Jovanović

Djordjević

et al. 2022

Serbian Journal of Experimental and Clinical Research

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“…However, we demonstrated the neuroprotective efficacy of the antioxidants (vitamins C and E) against this impairment. This was more evidenced following the co-administration of the vitamins probably due to the synergism in their actions (34,35), producing a complete antioxidant defense.…”

Section: Discussionmentioning

confidence: 99%

“…While vitamin C plays a role in recycling of vitamin E (24,29), vitamin E in turn, is involved in the biosynthesis of vitamin C (30,31). Therefore, the combination of the two vitamins may enhance their antioxidant potentials due to this synergistic interaction as reported in some studies (32)(33)(34)(35). We, therefore, aimed to investigate the effects of coadministration of vitamins C and E on reserpine-induced motor impairment in mice using…”

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confidence: 97%

Co-Administration of Vitamins C and E is Protective against Reserpine-induced Motor Impairment in Mice.

Danboyi¹,

Jimoh²,

lhassan³

et al. 2021

ABMS

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Background: The conventional treatments for Parkinson's disease, the most common movement disorder globally, have not been able to halt its progression hence, newer approaches targeting its pathogenesis are being explored. We investigated the effect of vitamins C and E (in combination) on reserpine-induced motor impairment in mice. Materials and Methods: Twenty-five mice were randomly grouped into five groups of five mice each. All the groups except group I (control), were given an alternate days injection of reserpine 0.1 mg/kg intraperitoneally. Groups III and IV were administered vitamin E 200 mg/kg/day (vitamin E group), and vitamin C 250 mg/kg/day (vitamin C group), respectively while group V (co-administered group) was given both vitamins orally. Group II (reserpine group) received nothing in addition to reserpine. All drugs were given concurrently for 28 days. The neurobehavioral assessment was performed using beam walking and open field tasks. Results were presented as mean±SEM and statistical significance was placed at p < 0.05. Results: There were significant increases in a number of foot slips (3.60±0.68; p = 0.002) and the time spent in reaching the 'safe' platform (36.60±5.78 s; p = 0.0001) in the reserpine group, both of which were markedly reduced in the co-administered group (0.25±0.25 and 3.00±0.41s respectively). The co-administered group demonstrated a marked decrease in transfer latency (10.33±1.45s; p = 0.005) and crossed significantly more lines (56.00±13.53 lines; p = 0.0001) in the open field compared to the reserpine group (214.00±64.16s and 4.3±1.67 lines respectively). Conclusion: Co-administration of vitamins C and E protected against motor impairment induced by reserpine in mice.

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“…The conversion of hypoxanthine to uric acid is catalyzed by the enzyme xanthine oxidoreductase, which exists in 2 forms: xanthine dehydrogenase and xanthine oxidase [25]. Vitamin E has been proposed to inhibit the activity of xanthine oxidase [26, 27]. Recent studies have shown that intestinal microbiota are involved in the metabolism of purine and uric acid [28, 29].…”

Section: Discussionmentioning

confidence: 99%

Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

Zhang

Shi

et al. 2020

Ann Nutr Metab

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Introduction: Current evidence on the association between dietary vitamin E intake and hyperuricemia risk is limited and conflicting. Objective: The aim of the study was to assess the association of dietary vitamin E intake with hyperuricemia in US adults. Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey, 2009–2014. Dietary vitamin E intake was evaluated through two 24-h dietary recall interviews. Logistic regression and restricted cubic spline models were used to examine the association between dietary vitamin E intake and hyperuricemia. Results: Overall, 12,869 participants were included. The prevalence of hyperuricemia was 19.35%. After adjustment for age, gender, BMI, race, educational level, smoking status, alcohol consumption, physical activity, total daily energy intake, total cholesterol, protein intake, glomerular filtration rate, serum Cr, use of uric acid drugs, and drug abuse, the odds ratio (95% confidence interval) of hyperuricemia for the highest tertile of dietary vitamin E intake was 0.77 (0.63–0.96) compared with that of the lowest tertile. In men, dietary vitamin E intake and hyperuricemia were negatively correlated. In stratified analyses by age (20–39, 40–59, and ≥60 years), dietary vitamin E intake was inversely associated with hyperuricemia only among participants aged ≥60 years. Dose-response analyses showed that dietary vitamin E intake was inversely associated with hyperuricemia in a nonlinear manner. Conclusion: Dietary vitamin E intake was negatively correlated with hyperuricemia in US adults, especially among males and participants aged ≥60 years.

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Effects of L-Ascorbic Acid and Alpha-Tocopherol on Biochemical Parameters of Swimming-Induced Oxidative Stress in Serum of Guinea Pigs

Cited by 9 publications

References 25 publications

Superoxide Dismutase 2 Val16Ala Polymorphism is Associated with Amiodarone-Associated Liver Injury

Superoxide Dismutase 2 Val16Ala Polymorphism is Associated with Amiodarone-Associated Liver Injury

Co-Administration of Vitamins C and E is Protective against Reserpine-induced Motor Impairment in Mice.

Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

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