Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

Zhang, Lixia; Shi, Xiaoyan; Yu, Jianning; Zhang, Peipei; Ma, Ping; Sun, Yongye

doi:10.1159/000509628

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…Further analyses of OBS subclasses demonstrated the significant negative associations of dietary and lifestyle OBS with HUA. Multiple dietary nutrient intake including B group vitamins, such as vitamin B6, vitamin B12, and folate, and other nutrients such as fiber, retinol, zinc, magnesium, vitamin C, and vitamin E has been proven to be negatively correlated with HUA risk, while dietary fat intake is suggested to be positively related to HUA risk in men with CKD (47)(48)(49)(50)(51)(52)(53)(54). Nevertheless, dietary OBS was significantly associated with HUA but not gout, and more high-quality studies such as randomized controlled trials and prospective cohort studies are urged to verify the validity of our results and explore possible mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Associations of oxidative balance score with hyperuricemia and gout among American adults: a population-based study

Wang,

Wu,

Deng

et al. 2024

Front. Endocrinol.

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ObjectiveThe current study aimed to assess the relationships between oxidative balance score (OBS) and OBS subclasses (dietary and lifestyle OBS) with risks of hyperuricemia (HUA) and gout among American adults.MethodsParticipants in the National Health and Nutrition Examination Survey from 2007 to 2018 were initially recruited and then the final sample was restricted to adults without missing values about serum uric acid, gout, OBS, and covariates. Rao-Scott adjusted chi-square test and analysis of variance were utilized to compare the baseline characteristics in adults of different quartiles of OBS, while the weighted stepped logistic regression models were used to explore the associations of overall, dietary, and lifestyle OBS with the risks of HUA and gout. Weighted restricted cubic spline analyses were conducted to explore the nonlinear dose-response associations.ResultsThe final sample consisted of 22,705 participants aged 20 years and older, which was representative of approximately 197.3 million non-institutionalized American adults. HUA and gout prevalence decreased with OBS quartiles. Compared with adults in the first quartile of OBS, those in the second (OR: 0.85, 95% CI: 0.72–0.99), third (OR: 0.71, 95% CI: 0.58–0.85), and fourth (OR: 0.48, 95% CI: 0.38–0.61) quartiles of OBS had reduced risks of hyperuricemia. Similarly, adults in the second (OR: 0.70, 95% CI: 0.51–0.97) quartile of OBS was associated with lower gout risk in comparison to adults in the lowest quartile. Regarding OBS subclasses, dietary and lifestyle OBS were both negatively correlated with the risk of HUA, and only higher lifestyle OBS was significantly associated with lower gout risk. Furthermore, the subgroup analyses and interaction effects also substantiated similar effects. Significant nonlinear dose-response relationships were observed between overall, dietary, and lifestyle OBS with HUA risk as well as that of lifestyle OBS with gout risk.ConclusionThis study strongly suggests the significant negative associations of OBS with HUA and gout in American adults and provides a dietary and lifestyle guideline to reduce the risks.

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Section: Discussionmentioning

confidence: 99%

Associations of oxidative balance score with hyperuricemia and gout among American adults: a population-based study

Wang,

Wu,

Deng

et al. 2024

Front. Endocrinol.

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“…An in vitro study reported that vit C and vit E could inhibit XO activity. Studies have also suggested a negative association between vit E and HUA [ 12 , 13 , 32 ]. Similar associations and mechanisms have also been reported for dietary Zn [ 14 , 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007–2018

Lin,

Chen,

Lan

et al. 2023

International Journal of Endocrinology

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Hyperuricemia and its complications are severe risks to human health. Dietary intervention is considered an essential part of the management of hyperuricemia. Studies have reported that the intake of antioxidants has a positive effect on hyperuricemia. Here, we collected data from 8761 participants of the National Health and Nutrition Examination Survey for this analysis. Daily intakes of vitamins A, C, and E; manganese; selenium; and zinc were calculated as the composite dietary antioxidant index (CDAI). The participants were divided into four groups (Q1, Q2, Q3, and Q4) according to the CDAI. Univariate analysis was used to assess the association of covariates with hyperuricemia. The association between the CDAI and hyperuricemia was evaluated using multinomial logistic regression, and its stability was determined by stratified analysis. Our results revealed that the CDAI has a significant negative association with hyperuricemia (Q2: 0.81 (0.69, 0.95); Q3: 0.75 (0.62, 0.90); Q4: 0.65 (0.51, 0.82); P < 0.01 ). The results of stratified analysis emphasize that this association between CDAI and hyperuricemia is stable. In conclusion, this study suggested a negative association between the CDAI and hyperuricemia.

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“…The cross-sectional study evaluated the association of dietary vitamin E intake with hyperuricemia in US adults. The results indicated that it was negatively correlated with hyperuricemia, especially among males and participants aged ≥60 years [43]. Uric acid-lowering effect might be also observed in a vitamin D-rich diet.…”

Section: Vitamin Supplementation In the Treatment Of Goutmentioning

confidence: 90%

Nutritional factors in the prevention and treatment of gout

Sebastian

Wąsik²,

Wojtuś³

2023

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Introduction and purpose: Despite the fact that effective urate lowering therapy and anti-inflammatory drugs for the treatment of gout are commonly available, there is considerable interest in novel treatment approaches. Gouty patients often have a multitude of comorbidities, which lead to concern over drug–drug interactions and medication adverse events. Thus, diet modifications are examined as a way of nonpharmacological treatment of gout. In this review, we explore the potential impact of nutritional factors on hyperuricemia and clinical gout outcomes. A search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: Management in patients with gout should be holistic. Incorrect nutrition may lead to hyperuricemia. Studies to date suggest that avoidance of certain foods and beverages can decrease the frequency of gout flares. Weight loss may be beneficial for prevention as well as treatment of gout and its comorbidities. The impact of various types of diet on the course of gout has been given particular attention and recent research suggests that vegetarian, mediterranean and dash diets may be beneficial for gouty patients. Also, some vitamins and omega-3 PUFA have favorable effects and the potential clinical use in gout treatment. Conclusions: We propose that simple dietary regimens may be beneficial to complement therapeutic management or contribute to the prevention of flares in gout patients. Although piecemeal modifications of various nutrients often provide incomplete dietary recommendations, understanding the role of nutritional factors in gout development would be helpful for patients in choosing their healthy diet.

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Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

Cited by 14 publications

References 27 publications

Associations of oxidative balance score with hyperuricemia and gout among American adults: a population-based study

Associations of oxidative balance score with hyperuricemia and gout among American adults: a population-based study

Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007–2018

Nutritional factors in the prevention and treatment of gout

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