Effects of Acanthopanax senticosus supplementation on innate immunity and changes of related immune factors in healthy mice

Abstract

Modern scientific research has shown that Acanthopanax senticosus (AS) can regulate the innate immunity of healthy animals, thus affecting the health of animals. However, there are few systematic reports on the changes of innate immune indices of healthy animals after consuming AS. The purpose of this project was to study the effect on healthy mice’s innate immunity and changes of related immune factors induced by feeding AS root powder supplementation. The results showed that the killing rate of natural cells increased in a dose-dependent manner in a certain time period. Compared to the control group, the treatment groups (T1, T2 and T3) improved significantly in the innate immune index (lysozyme, β-defensin-2 and duodenal secretory IgA (SIgA) to varying degrees) and induced corresponding changes of immune factors at certain time periods. The correlation between SIgA and IFN-γ in mouse serum was enhanced, and the higher the concentration of AS in the diet, the stronger the correlation was. However, there was no significant difference in growth performance among groups. It is proved that AS supplementation can enhance innate immunity and change several relevant immune factors and cells of healthy mice without affecting growth performance.

A blend of Guava, Bitter, and Neem Leaf extracts improves haematology and resistance to co-infection of Streptococcus agalactiae and Aeromonas jandaie but not Liver health in Nile tilapia

“…In line with other results, significant increases in the expression of lysozymes following exposure to Azadirachta indica , and Zingiber officinale among others on Catfish, Pangasianodon hypophthalmus leukocytes have been reported [ 42 ]. Also, a mixture of A.membranaceus, A. sinensis , and C. hupehensis was found to induce the expression of HSP 70 in Nile tilapia [ 43 ] and the application of Acanthopanax senticosus have been reported to modulate the expression of lysozyme and Beta-defensin in mice [ 44 ] and ultimately low communicative mortalities after pathogen challenge tests.…”

Efficacy of complex phytoadaptogens as an adjunct to non-surgical treatment of chronic periodontitis: A randomized clinical trial

“…[ 26 ] The chronotropic effects of adaptogens enhance the therapeutic effect of CFA and NSPT through the pineal gland with the participation of melatonin and its receptors. [ 25 48 ] Melatonin has an anti-stress effect, altering biochemical and neurochemical processes in the hypothalamic structures of the brain. [ 46 49 , 50 ]…”