Efficacy of Complex Phytoadaptogens as an Adjunct to Non-surgical Treatment of Chronic Periodontitis

Dzampaeva, Zhanna V.; Datieva, Fatima S.; Esenova, Zaira Savelevna; Такоева, Е. А.

doi:10.4103/jispcd.jispcd_56_21

Cited by 2 publications

(4 citation statements)

References 47 publications

(64 reference statements)

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“…This implies that the BHP exhibits quite different pharmacological activities when the ingredients are combined. These findings are essential for understanding the unpredictable results of clinical studies of multi-component drugs and dietary supplements [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ].…”

Section: Synergy and Antagonism Of Active Ingredients Of Rh...mentioning

confidence: 99%

“…Eighteen clinical studies were conducted on the fixed combinations of R. rosea with green tea [ 49 , 50 , 51 , 52 , 53 ], Eleutherococcus, and Schisandra [ 54 , 55 , 56 , 57 ], Eleutherococcus, Schisandra, and Leuzea [ 56 ], caffeine [ 58 , 59 ], Cordyceps [ 60 , 61 , 62 , 63 ], Ginkgo [ 64 ], black cohosh [ 65 ], Saffron [ 66 ], L-carnosine [ 67 ], Eleutherococcus, and Glycyrrhiza [ 68 ].…”

Section: Introductionmentioning

confidence: 99%

“…This narrative state-of-the-art review provides the results of recent clinical [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ] and network pharmacology studies of the BHP of R. rosea with other plants [ 5 , 6 , 8 , 9 , 10 ]. The studies aim to reveal the molecular interactions in situ of host cells in response to the intervention of BHP and justify the benefits of implementing BHP in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

Panossian,

Lemerond,

Efferth

2024

Pharmaceuticals

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Background: Despite some evidence supporting the synergy concept, the commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet to be unambiguously and explicitly studied. Study aim: The study aimed to reveal the molecular interactions in situ of host cells in response to botanical hybrid preparations (BHP) intervention and justify the benefits of implementing BHP in clinical practice. Results: This prospective literature review provides the results of recent clinical and network pharmacology studies of BHP of Rhodiola rosea L. (Arctic root) with other plants, including Withania somnifera (L.) Dunal (ashwagandha), (Camellia sinensis (L.) Kuntze (green tea), Eleutherococcus senticosus (Rupr. and Maxim.) Maxim. (eleuthero), Schisandra chinensis (Turcz.) Baill. (schisandra), Leuzea carthamoides (Willd.) DC., caffeine, Cordyceps militaris L., Ginkgo biloba L.(ginkgo), Actaea racemosa L. (black cohosh), Crocus sativus L. (saffron), and L-carnosine. Conclusions: The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared to mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within the molecular networks involved in the cellular and overall response of organisms to the intervention. Network pharmacology studies help predict the results of studies aimed at discovering new indications and unpredicted adverse events.

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Section: Synergy and Antagonism Of Active Ingredients Of Rh...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

Panossian,

Lemerond,

Efferth

2024

Pharmaceuticals

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“…Seventeen clinical studies were conducted on the fixed combinations of Rhodiola rosea with Green Tea [39][40][41][42][43], Eleutherococcus, and Schisandra [44][45][46][47][48][49], Eleutherococcus, Schisandra, and Leuzea [47,48], caffeine [50], Cordyceps [51][52][53][54], Gingko [55], Black Cohosh [56], saffron [57], L-carnosine [58], Eleutherococcus and Glycyrrhiza glabra [59]. The use of complex herbal formulations comprising fixed combinations of several plant extracts has a long history in TCM, Kampo, Ayurveda, and other traditional medical systems.…”

Section: Introductionmentioning

confidence: 99%

Botanical hybrid preparations (BHP) in phytomedicine and phytotherapy research: background and perspectives

Panossian,

Lemerond,

Efferth

2024

Preprint

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Background: The commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has not been systematically studied despite some evidence supporting the synergy concept. Study aim: The study aimed to reveal the molecular interactions in situ of host cells in response to the intervention of BHP and justify the benefits of implementing BHP in clinical practice. Results: This overview provides the results of recent clinical and network pharmacology studies of botanical herbal preparations (BHP) of Rhodiola with other plants, including Ashwagandha, Green Tea, Eleutherococcus, Schisandra, Eleutherococcus, Leuzea, Caffeine, Cordyceps, Gingko, Black Cohosh, saffron, and L-carnosine. Conclusions: The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared with mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within molecular networks involved in the cellular and overall response of organisms on the intervention. Network pharmacology studies help predict the results of studies to discover new indications and unpredicted adverse events.

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Efficacy of Complex Phytoadaptogens as an Adjunct to Non-surgical Treatment of Chronic Periodontitis

Cited by 2 publications

References 47 publications

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

Botanical hybrid preparations (BHP) in phytomedicine and phytotherapy research: background and perspectives

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