Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1 and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers

Bosso, Rosa Maria do Vale; Amorim, Lı́dia Maria da Fonte de; Andrade, Sônia Gumes; Rossini, Ana; Marchi, Mary Rosa Rodrigues de; Carareto, Claudia M. A.; Conforti-Froes, Nívea

doi:10.1016/j.scitotenv.2006.07.025

Cited by 20 publications

(15 citation statements)

References 34 publications

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“…At low levels of PAH exposure, possibly complete catalysis and conjugation of diol epoxide metabolites with reduced glutathione takes place protecting individuals from PAH-induced mutagenesis and carcinogenesis. These results were similar to the findings of do Vale Bosso et al 63) They monitored the CYP1A1 polymorphism in sugarcane workers exposed to PAH (harvesting) and the GSTP1 polymorphism in the non-exposed (non-harvesting) group significantly influenced urinary 1-OHP excretion. Lee et al 64) found CYP1A1 and GSTM1 polymorphisms were statistically significant in analyses of 1-OHP levels among aircraft maintenance workers who smoked.…”

Section: Discussionsupporting

confidence: 90%

Urinary 1‐Hydroxypyrene Level Relative to Vehicle Exhaust Exposure Mediated by Metabolic Enzyme Polymorphisms

Chuang

Chang

2007

Journal of Occupational Health

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Urinary 1-Hydroxypyrene Level Relative to Vehicle Exhaust Exposure Mediated by MetabolicEnzyme Polymorphisms: Chun-Yu CHUANG, et al. Department of Biomedical Engineering andEnvironmental Sciences, National Tsing-Hua University, Taiwan-Polycyclic aromatic hydrocarbons (PAH) are common air pollutants generated from incomplete combustion. The inhalation of exhaust fumes in urban areas has been suggested to be an additional contributing factor. This study investigated the influence of urban traffic exposure, personal lifestyle factors and metabolic enzyme polymorphisms on the urinary 1-hydroxypyrene (1-OHP) level, approximating exposure to PAH. With consents, 95 male taxi drivers exposed to vehicle exhaust in traffic and 75 male office employees received health interviews and provided urine samples. The results showed taxi drivers had higher urinary 1-OHP than the office employees (mean ± standard deviation were 0.17 ± 0.10 vs. 0.10 ± 0.07 µmol/mol creatinine, p<0.001). The average urinary 1-OHP level increased from 0.07 µmol/mol creatinine for non-smoking office employees to 0.17 µmol/mol creatinine for those who smoked more than 20 cigarettes daily. The values for taxi drivers with similar smoking statuses were 0.12 and 0.25 µmol/mol creatinine, respectively. Among non-smokers, taxi drivers still had higher 1-OHP level than office employees (0.12 ± 0.05 vs. 0.07 ± 0.03 µmol/mol creatinine). The subjects with the m1/m2 or m2/m2 genotype of CYP1A1 MspI or GSTM1 deficiency had significantly higher urinary 1-OHP levels than those with other CYP1A1 MspI and GSTM1 genotypes. Multivariate logistic regression analysis showed that taxi drivers (adjusted odds ratio (OR)=5.1, 95% confidence interval (CI)=1.1-13.6), smokers (OR=5.5, 95% CI=1.6-18.4) and subjects with the m1/m2 or m2/ m2 genotype of CYP1A1 MspI (OR=9.7, 95% CI=2.7-35.0) had elevated urinary 1-OHP (greater than the overall median value, 0.11 µmol/mol creatinine). The results of this study suggest smoking contributes to the elevated urinary 1-OHP levels in taxi drivers in addition to taxi driving, and the excess level contributed from traffic exhaust and smoke was regulated by the CYP1A1 MspI genotype. Traffic exhaust exposure, smoking and CYP1A1 MspI genotype contributed to the variation in levels of urinary 1-OHP excretion.

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Section: Discussionsupporting

confidence: 90%

Urinary 1‐Hydroxypyrene Level Relative to Vehicle Exhaust Exposure Mediated by Metabolic Enzyme Polymorphisms

Chuang

Chang

2007

Journal of Occupational Health

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“…Three studies 18 , 47 , 48 carried out in sugarcane regions found increased values in the markers of exposure to aromatic hydrocarbons in workers involved in sugarcane cutting. A study involving 90 cutters showed that the concentration of 1-OH-Pyrene in the urine was 11 times higher in the harvest period than in the pre-harvest period 18 .…”

Section: Resultsmentioning

confidence: 99%

“… Coble et al 70 (2003) Case-control study The relationship between occupational exposures and oral cavity or pharynx cancer (n = 367) Puerto Rico High cancer risks were observed among sugarcane producers and in individuals with high cumulative exposure to solvents. Bosso et al 47 (2006) Longitudinal study To evaluate the concentrations of 1-hydroxypyrene in the urine of 39 sugarcane workers State de São Paulo, Brazil The level of 1-OHP in urine was 9 times higher in exposed workers compared to those not exposed. Martinez-Vanezuela et al 48 (2015) Cross-sectional study To determine the chromosomal damage in oral mucosa in workers exposed to burnt sugarcane in Mexico (n = 60) compared to non-exposed workers (n = 60) Higher presence of chromosomal micronuclei in oral mucosa and nuclear abnormalities in exposed workers, compared to non-exposed individuals.…”

Section: Resultsmentioning

confidence: 99%

Sugarcane cutting work, risks, and health effects

et al. 2018

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OBJECTIVE Describe the main work risks for sugarcane cutters and their effects on workers’ health.METHODS Critical review of articles, with bibliographic research carried out in the PubMed, SciELO Medline, and Lilacs databases. The following keywords were used: sugarcane workers, sugarcane cutters, sugarcane harvesting, cortadores de cana-de-açú car , and colheita de cana -de-açúcar . The inclusion criteria were articles published between January 1997 and June 2017, which evaluated working conditions and health effects on sugarcane cutters. Those that did not deal with the work impact of cutting burned and unburnt sugarcane in the cutter’s health were excluded. The final group of manuscripts was selected by the lead author of this study and reviewed by a co-author. Disagreements were resolved by consensus using the predefined inclusion and exclusion criteria and, where necessary, the final decision was made by consulting a third co-author.RESULTS From the 89 articles found, 52 met the selection criteria and were evaluated. Studies have shown that cutters work under conditions of physical and mental overload, thermal overload, exposure to pollutants, and are subject to accidents. The main effects observed were respiratory, cardiovascular, renal, musculoskeletal, heat stress, dehydration, genotoxic, and those due to accidents.CONCLUSIONS Work on the manual cutting of sugarcane, especially of burned sugarcane, exposes workers to various risks, with different health impacts. Risk reduction for exposure to pollution and thermal and physical overload is required as a measure to preserve the health of the worker.

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“…The environmental or occupational exposure to polycyclic aromatic hydrocarbons (PAH) can be monitored by the quantitation of metabolic intermediates of frequent and abundant chemicals in the mixture, such as 1-hydroxypyrene (1-OHP), the main pyrene metabolite (90%), with an average half-life of approximately 18-20 hours after pyrene inhalation (5). Urinary 1-OHP is routinely used as a biomarker in workers occupationally exposed to PAHs (6)(7)(8), tobacco smokers (9,10) and the general population exposed to airborne pollution (11)(12)(13) Requisites that a biological response should comply to be considered as a biomarker for health assessment (HPLC-FD), and/or gas chromatography coupled to mass spectrometry (GC-MS); its quantitation has shown a good correlation with PAH human exposure at both high and low environmental levels (5).…”

Section: Biomarkers Of Internal Dosementioning

confidence: 99%

Molecular biomarkers to assess health risks due to environmental contaminants exposure

Poblete-Naredo

Albores

2016

biomedica

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<p>Los biomarcadores, o bioindicadores, son herramientas métricas que, al compararse con los valores de referencia, permiten evaluar los riesgos y generar información objetiva que ayude a las autoridades a planificar estrategias efectivas, solucionar problemas de salud o ambientales y utilizar los recursos asignados de manera eficiente.<br />La evaluación de riesgos en salud es un ejercicio multidisciplinario y la biología molecular contribuye enormemente a estos estudios, dado que el genoma, el transcriptoma, el proteoma y el metaboloma pueden verse afectados por xenobióticos, lo que causa cambios cuya medición resulta útil en la adopción de decisiones. Dichos cambios pueden variar por la carga genética de cada individuo y su distribución polimorfa en las poblaciones expuestas se convierte en un factor esencial para una adecuada interpretación de resultados.<br />Por lo tanto, el objetivo del presente artículo fue hacer una revisión de los diferentes biomarcadores moleculares aplicables a la evaluación de riesgos para la salud provenientes de los contaminantes ambientales.</p>

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Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1 and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers

Cited by 20 publications

References 34 publications

Urinary 1‐Hydroxypyrene Level Relative to Vehicle Exhaust Exposure Mediated by Metabolic Enzyme Polymorphisms

Urinary 1‐Hydroxypyrene Level Relative to Vehicle Exhaust Exposure Mediated by Metabolic Enzyme Polymorphisms

Sugarcane cutting work, risks, and health effects

Molecular biomarkers to assess health risks due to environmental contaminants exposure

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