Effects of Gamma Radiation on Some Hematological Parameters in Female Rats

Abstract

The effect of low exposure doses of gamma ray at doses of 0.055 Gy, 0.11 Gy and 0.165 Gy on the some hematological parameters of albino female rats were investigated. At the end of exposure periods and Blood samples were collected for analyses. The results obtained when increases of gamma ray doses of rats caused significant, p ≤ 0.05, decrease in the RBCs, Hb and Ht%. Also it was found elevation in MCV and MCH with increased exposure dose as well as significant decreases, p≤ 0.05, Platelets in decreasing with increasing of doses rate and while MCHC% did not change significantly. But it was found when increases of gamma ray doses of rats caused significant, p ≤ 0.05, decrease in WBCs count, lymphocytes count, monocytic, neutrophils, esinophiles and basophiles respective controls. These findings on the some hematological parameters suggest that the changes in blood parameters of the treated rats were due to the exposure of low doses of gamma ray.

Effect of Low Dose (Diagnostic X-Rays) on Peripheral White Blood Cells Count in Guinea Pigs (Cavia porcellus)

“…Previous studies have reported similar findings [6,17,30]. The observed decline in the white blood cell counts could be attributed to high radio-sensitivity of hematopoietic tissues [6,31]. The results are consistent with the previous findings that irradiation induces leucopenia and reduces lymphocytes, neutrophils and monocytes count [32,33].…”

“…This probably could be because basophils naturally are rarely encountered granulocytes in the peripheral blood, therefore, it is not unusual for basophils to be absent [29]. Previous studies have reported similar findings [6,17,30]. The observed decline in the white blood cell counts could be attributed to high radio-sensitivity of hematopoietic tissues [6,31].…”

“…Exposure to radiation results in a deposition of energy in tissues that can damage cellular structures including DNA [5]. The degree of the damage due to the radiation depends on the type of radiation, energy of the radiation, intensity of the radiation, and exposure time [6]. Depending on the duration of exposure, the area exposed and the dose received, radiation exposure in the immediate aftermath could lead to a myriad of deleterious effects including acute radiation syndrome [7].…”

“…The biological effect of ionizing radiation arises from the deposition energy in the tissues which can cause changes in the chemical composition of the cell. The energy of the ionizing radiation is significantly greater than the bond energies of many molecules and can cause homolytic bond scission and generation of secondary electrons [6]. Ionizing radiation is thus seen to affect biological tissues by directly dissociating molecules following their excitation and ionization, or indirectly by the production of free radicals and hydrogen peroxide in the water of the body fluids [15], and the severity of the effect increases with dose and dose rate [16].…”

Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats

“…Ionizing radiation (IR) can cause changes in the chemical balance of cell and affects humans by depositing energy in body tissue [1]. Exposure to ionizing radiation increase the production of reactive oxygen species (ROS) such as superoxide (O 2-), hydroxyl radical (OH·) and hydrogen peroxide (H 2 O 2 ) and cause lipid peroxidation in cell membrane and damage to cellular activities leading to physiological disorders and dysfunction of cells and tissues [2].…”