Studying the Ameliorative Effect of Bee Venom Against Damage and Inflammation Induced in Gamma-Irradiated Rats

Shaaban, Ashraf Mohamed Mounir; Hamza, R. G.; shahat, A.N. El

doi:10.21608/ajnsa.2018.3107.1071

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…While groups treated with bee venom using both doses (0.5 and 1.23 mg/kg) and the combined therapy (metformin and atorvastatin) showed a significant decline in malondialdehyde levels in comparison to the positive control. These results follow a previous study, 79 which reported that the treatment with bee venom leads to a reduction in the malondialdehyde levels in heart tissue compared to positive control because of the anti-oxidative activity of bee venom.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, they are compatible with other studies, 77,78 which found that the activities of CK-MB and LDH were raised in STZ-diabetic rats, likely due to disruption of myocardial structure induced by reactive oxygen species, while groups treated with bee venom using both doses (0.5 and 1.23 mg/kg) and the combined therapy (metformin and atorvastatin) showed a significant reduction ( P < 0.0001) in CK-MB and LDH activities when compared to the positive control. These results are in accordance with Shaaban and Hamza, 79 who stated that treatment with bee venom resulted in a reduction in CK-MB and LDH activities compared to the positive control. The ameliorating effect of bee venom on CK-MB and LDH activities could be because of its antioxidant effect by suppressing the formation of free radicals, scavenging free radicals, preventing lipid peroxidation of membranes, and maintaining membrane integrity, thus limiting the outflow of these enzymes.…”

Section: Discussionsupporting

confidence: 92%

“…While groups treated with bee venom using both doses (0.5 and 1.23 mg/kg) and the combined therapy (metformin and atorvastatin) showed a significant reduction in the concentration of troponin I when compared to the positive control. These results are in accordance with Shaaban and Hamz,a 79 who stated that treatment with bee venom resulted in a reduction in troponin I levels compared to the positive control group, demonstrating the myocardial protection of bee venom because of the antioxidant effect of bee venom.…”

Section: Groupssupporting

confidence: 91%

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Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats

Zahran

Mohamad

Zein

2021

Exp Biol Med (Maywood)

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High levels of blood glucose and lipids are well-known risk factors for heart diseases. Bee venom is a natural product that has a potent hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant effects. The current study aimed to determine the bee venom effects on cardiac dysfunction compared to combined therapy of metformin and atorvastatin in diabetic hyperlipidemic rats. The median lethal dose of bee venom was estimated, and then 50 adult male albino rats were categorized into five groups. One group was fed a standard diet and served as a negative control, while the other groups were given nicotinamide and streptozotocin injections to induce type 2 diabetes. After confirming diabetes, the rats were fed a high-fat diet for four weeks. The four groups were divided as follows: one group served as a positive control, whereas the other three groups were treated with bee venom (0.5 mg/kg), bee venom (1.23 mg/kg), and combined therapy of metformin (60 mg/kg) and atorvastatin (10 mg/kg), respectively, for four weeks. Upon termination of the experiment, blood samples and heart tissue were obtained. Administration of bee venom using both doses (0.5 and 1.23 mg/kg) and combined therapy of metformin and atorvastatin revealed a significant decrease in the concentrations of glucose, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, troponin I, creatine kinase, and lactate dehydrogenase activities. Moreover, a significant decrease had been detedcted in malondialdehyde, nuclear factor-kappa-β levels, and relative mRNA expression of vascular cell adhesion molecule-1 and galectin-3 in heart tissue compared to the positive control ( P < 0.0001). Furthermore, there was a significant increase in bodyweight levels of insulin, high-density lipoprotein cholesterol, and total antioxidant capacity in heart tissue compared to the positive control ( P < 0.0001). The results indicate that bee venom can ameliorate cardiac dysfunction through attenuating oxidative stress and downregulating the NF-κβ signaling pathway.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Groupssupporting

confidence: 91%

See 1 more Smart Citation

Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats

Zahran

Mohamad

Zein

2021

Exp Biol Med (Maywood)

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“…In a similar study, they found decreased SOD, CAT and GSH activity according to the control group in rat liver irradiated with 6 Gy gamma-ray. In the bee venom + irradiated group, biochemical parameters, there were significant changes compared to the irradiated group (29).…”

Section: Discussionmentioning

confidence: 81%

Protective effect of different doses of pycnogenol extract against gamma radiation-induced liver damage in rat

Tan¹

2020

Erciyes Med J

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The study aims to investigate the protective role of pycnogenol extract against liver damage in whole-body gamma-irradiated rats by assessing DNA damage, histopathological changes and biochemical parameters.Materials and Methods: Rats were irradiated to a single fraction 900 cGy dose of gamma radiation. The pycnogenol extract was dissolved 5% DMSO and daily administrated before starting irradiation. The pycnogenol was administered orally via a gastric tube at a dose of 37.5 mg/kg, 75 mg/kg, 150 mg/kg and 300 mg/kg in 24, 48 and 72 h before irradiation. Irradiation was applied single fraction using Cobalt-60 teletherapy device. The animals were divided into ten groups that included control, pycnogenol extract groups only irradiation group (γ-ray) and pycnogenol extract + γ-ray groups. DNA damage, histopathological changes, catalase (CAT) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels in the liver tissue of rats were evaluated three days after irradiation Results: Our results obtained that pycnogenol extract was induced to liver damage depend on pycnogenol extract dose, but the pycnogenol extract + γ-ray groups were significantly ameliorated the changes induced in liver antioxidant system; CAT, SOD and MDA. Also, the P300+γ-ray was significantly reduced irradiation-induced liver injury and it was possible to observed significantly preservation in the histopathological evaluation. The pycnogenol extract groups were significantly increased to comet parameter depend on pycnogenol doses compared to control. The pycnogenol extract + γ-ray were significantly decreased the comet parameter compared to the γ-ray group. Conclusion:The administration of pycnogenol extract might provide substantial protection against radiation-induced oxidative, DNA damage and histopathological changes in the liver.

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“…Bee venom protects from the gamma and X-ray radiation in numerous assessment systems ( Gajski and Garaj-Vrhovac 2009 ). Also, BV has antioxidant efficacy and can neutralize free radicals and protect the body from toxic radiation ( Shaaban and Hamza 2019 ). BV defends the bone marrow cells from chromosomal abnormalities (aberrations) in vivo in the Wistar mice model ( Varanda and Tavares, 1998 , Bellik, 2015 ).…”

Section: Pharmacological Properties Of Honey Bee Venommentioning

confidence: 99%