Effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

Flaxseed Oil Supplementation Augments Antioxidant Capacity and Alleviates Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…In the study conducted by Jamilian et al, a 6-week supplementation with 2000 mg/day flaxseed oil in patients with GDM significantly decreased MDA levels [ 11 ]. Similar to the previous study, two studies have shown that flaxseed oil significantly reduces MDA [ 26 , 33 ]. However, there are some studies that showed the effects of 1000 mg/day of flaxseed oil on the MDA level were not significant [ 23 ].…”

“…An earlier meta-analysis [ 26 ] showed a significant reduction in serum MDA. It increased TAC, but no change in the GSH level was observed in patients with metabolic syndrome and related disorders following supplementation with flaxseed oil.…”

“…The results were similar to those of the present study. However, some limitations of a previous meta-analysis [ 26 ] may distort its findings. For example, many publications have been missed and not included in the analysis despite being eligible according to inclusion criteria [ 24 , 33 , 35 ].…”

“…A previous meta-analysis published in 2020 assessed the antioxidant effects of flaxseed oil supplementation on biomarkers of oxidative stress using 5 studies. The results showed that flaxseed oil reduces MDA and increases TAC levels, but no significant effect was observed on GSH levels [ 26 ], although changes of some biomarkers of oxidative stress have not been assayed in detail. Therefore, present meta-analysis was conducted to summarize current evidence and estimate the direction and magnitude of the effects of flaxseed oil supplementation on oxidative stress biomarkers in adults.…”

Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

“…Concerning nutritional strategies to improve obesity-induced OS, linseed oil (LO) could be of interest. A recent systematic review of randomized controlled trials in patients with metabolic syndrome and related disorders demonstrated that LO supplementation significantly reduces malonedialdehyde (MDA), a lipid peroxidation marker, and increases the total antioxidant capacity [21]. Among the different bioactive compounds contained in LO, alpha-linoleic acid (ALA; the most abundant) [22,23], phytosterols [24], antioxidant vitamins (especially γ-tocopherol and β-carotene; present at lower concentration), and phenolic compounds [25] have a strong antioxidant activity.…”