Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Groussard, Carole; Plissonneau, Claire; Josset, Laurie; Capel, Frédéric; Mura, Mathilde; Gouraud, Etienne; Mairesse, Guillaume; Chesneau, Guillaume; Barnich, Nicolas; Pialoux, Vincent

doi:10.3390/nu13103531

Cited by 4 publications

(1 citation statement)

References 69 publications

(91 reference statements)

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“…It is reported that cell senescence is closely related to ROS levels (Xiao, Jedrychowski, et al, 2020). SOD and CAT, the typical intracellular antioxidant enzymes, synergistically inactivate the superoxide radicals and hydrogen peroxide in cells, thereby protecting cells from oxidative stress (Groussard et al, 2021). It was reported that saponins from the Rosa laevigata Michx fruit remarkably increased the levels of SOD and CAT, and decreased MDA and iNOS levels in the liver of mice to play a role in the hepatoprotective effect (Dong et al, 2013).…”

Section: Bms Resisted the Oxidative Stress Of C Elegansmentioning

confidence: 99%

Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir‐2.1 and hlh‐30

Zhang

Wang

et al. 2022

Journal of Food Biochemistry

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Saponins from bitter melon (BMS) exert potential bioactivities and pharmacological activities, including anti‐oxidation and lifespan extension. However, the exact mechanisms of BMS in response to oxidative stress remain unknown. Results demonstrated that bitter melon saponins could strengthen locomotive activities (body bend and head thrashing) accompanied by delaying the muscle fiber damage with age in Caenorhabditis elegans. In addition, BMS inhibited the ROS accumulation, improved the activities of antioxidant enzymes like SOD (by 57.90% and 94.34% for 100 μg/ml and 200 μg/ml BMS, respectively) and CAT (by 51.45% and 56.91% for 100 μg/ml and 200 μg/ml BMS, respectively), and extend the lifespan of N2 and CL2006 worms under paraquat‐induced oxidative stress. Mechanism study suggested that BMS modulated the mRNA expressions of oxidation‐related regulators, like the upregulation of cat‐1, hsf‐1, sir‐2.1, and hlh‐30. Furthermore, gene‐deficient mutants verified that IIS (insulin/insulin‐like growth factor‐1 signaling) pathway linked with sir‐2.1 and hlh‐30 factors were involved in the BMS's lifespan‐extension effects under oxidative stress. In general, this study supplemented the explanation of BMS in promoting oxidation‐resistance and lifespan‐extension activities, which could be served as a potential candidate for anti‐aging. Practical applications Our previous studies have suggested that saponins from bitter melon exhibited fat‐lowering activity in C. elegans. However, little was known about the mechanism underlying the anti‐oxidation effects of BMS in C. elegans. Current results indicated that the IIS pathway linked with sir‐2.1 and hlh‐30 transcriptional factors jointly to increase the lifespan in BMS' responses to oxidative stress. Our findings are beneficial to understand the main nutritional ingredients in bitter melon, which are ideal and expected in functional foods for aging.

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Section: Bms Resisted the Oxidative Stress Of C Elegansmentioning

confidence: 99%

Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir‐2.1 and hlh‐30

Zhang

Wang

et al. 2022

Journal of Food Biochemistry

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High-intensity intermittent training ameliorates methotrexate-induced acute lung injury

Rajizadeh,

Hosseini,

Bahrami

et al. 2024

BMC Pulm Med

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Inflammation and oxidative stress are recognized as two primary causes of lung damage induced by methotrexate, a drug used in the treatment of cancer and immunological diseases. This drug triggers the generation of oxidants, leading to lung injury. Given the antioxidant and anti-inflammatory effects of high-intensity intermittent training (HIIT), our aim was to evaluate the therapeutic potential of HIIT in mitigating methotrexate-induced lung damage in rats. Seventy male Wistar rats were randomly divided into five groups: CTL (Control), HIIT (High-intensity intermittent training), ALI (Acute Lung Injury), HIIT+ALI (pretreated with HIIT), and ALI + HIIT (treated with HIIT).HIIT sessions were conducted for 8 weeks. At the end of the study, assessments were made on malondialdehyde, total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (Gpx), myeloperoxidase (MPO), interleukin 10 (IL-10), tumor necrosis factor-alpha (TNF-α), gene expression of T-bet, GATA3, FOXP3, lung wet/dry weight ratio, pulmonary capillary permeability, apoptosis (Caspase-3), and histopathological indices.Methotrexate administration resulted in increased levels of TNF-α, MPO, GATA3, caspase-3, and pulmonary edema indices, while reducing the levels of TAC, SOD, Gpx, IL-10, T-bet, and FOXP3. Pretreatment and treatment with HIIT reduced the levels of oxidant and inflammatory factors, pulmonary edema, and other histopathological indicators. Concurrently, HIIT increased the levels of antioxidant and anti-inflammatory factors.

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Effects of Omega-3 Supplementation on the Delayed Onset Muscle Soreness after Cycling High Intensity Interval Training in Overweight or Obese Males

Makaje,

Ruangthai,

Sae-tan

2024

jsportscimed

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People with overweight or obesity preferred high-intensity interval training (HIIT) due to the time-efficiency and pleasure. However, HIIT leads to delayed onset muscle soreness (DOMS). The present study aimed to investigate the effects of omega-3 supplementation on DOMS, muscle damage, and acute inflammatory markers induced by cycling HIIT in untrained males with overweight or obesity. A randomized, double-blinded study was used in the present study. Twenty-four males with a sedentary lifestyle were randomly assigned to either receive omega-3 (O3) (4 g fish oil) or placebo (Con). Subjects consumed the capsules for 4 weeks and performed cycling HIIT at the 4th week. After 4 weeks-intervention, the omega-3 index of O3 group increased by 52.51% compared to the baseline. All subjects performed HIIT at 4th week. The plasma creatine kinase (CK) level of Con group increased throughout 48h after HIIT. While the CK level of O3 group increased only immediately and 24h after HIIT and decreased at 48h after HIIT. The white blood cell count (WBC) of Con group increased immediately after the HIIT, while O3 group did not show such increase. There was no change of CRP in both groups. O3 group had a higher reduction of calf pain score compared to Con group. O3 group also showed a recovery of leg strength faster than Con group. Omega-3 supplementation for 4 weeks lower increased CK level, reduced calf pain score, and recovery leg strength, DOMS markers after cycling HIIT.

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Beneficial Effects of High Intensity Interval Training and/or Linseed Oil Supplementation to Limit Obesity-Induced Oxidative Stress in High Fat Diet-Fed Rats

Cited by 4 publications

References 69 publications

Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir‐2.1 and hlh‐30

Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir‐2.1 and hlh‐30

High-intensity intermittent training ameliorates methotrexate-induced acute lung injury

Effects of Omega-3 Supplementation on the Delayed Onset Muscle Soreness after Cycling High Intensity Interval Training in Overweight or Obese Males

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