ObjectiveThis study aimed to determine the relationship between the high dietary acid load (DAL) and the risk of cancer.MethodsFive databases of PubMed, Web of Sciences, Scopus, Cochrane Library, and Google Scholar was searched to elicit original studies on humans, up to June 2021. Quality of the articles, risk of bias, and heterogeneity were assessed. A random-effects meta-analysis model was applied to estimate pooled effect size with a 95% confidence interval. Sensitivity analysis was performed using a fixed-effects model. Subgroup analyses were carried out based on gender, age, type of cancer, and type of DAL assessment indicator.ResultsSeventeen effect sizes from 10 articles were included in the analysis. Overall, individuals with the highest DAL were associated with a 66% increased risk of cancer compared to those with the lowest DAL (p < 0.001]. The risk of cancer increased 41% (p < 0.001) and 53% (p = 0.03) by high PRAL and NEAP, respectively. High DAL was associated with 32% (p < 0.001) and 79% (p < 0.001) increased risk of breast and colorectal cancers, respectively. High DAL was associated with 32% (p = 0.001) and 76% (p = 0.007) increased risk of cancer incident in women and men, respectively. The risk of cancer incident increased 35% (p < 0.001) and 49% (p < 0.001) at age ≤ and > of 50, respectively.ConclusionHigh DAL may be associated with a higher risk of cancer incidence not only in the whole studied population but also across cancer types, both genders, both DAL assessment indicators, and also among both high- and low-risk age groups for cancer.

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Artichoke (Cynara scolymus L.) is a perennial plant native to the southern Mediterranean region of North Africa. Today, artichokes are widely grown around the world and buds of artichokes are used as a vegetable all over the world. This plant is widely used in the traditional medicine. Artichoke has antioxidant and anti-inflammatory effects, and countless medicinal properties. Artichoke inhabits reactive oxygen species (ROS) and free radicals due to phenolic acids and flavonoid compounds and also suppresses the activation pathway of NF-κB, thereby could reduce oxidative stresses, inflammatory factors, and prevent suppressing red blood cells probably. It has also been suggested for traditional medicine including blood purification, so it can be used for anemia treatment.

Objective. Studies have reported controversial findings regarding the flaxseed oil effect on antioxidant status biomarkers. The present meta-analysis aimed to determine the impact of flaxseed oil on the serum level of biomarkers of oxidative stress. Methods. A systematic search was conducted up to November 2020 on PubMed, Embase, Web of Science, Scopus, and Cochrane Central Library. Random-effects model was employed to perform meta-analysis. Subgroup analysis was carried out to determine the effect across different ranges of dosages and durations. Results. Eight trials were included with a total sample size of 429 individuals with a mean age range of 25 to 70 years. The results indicated that flaxseed oil supplementation led to a significant decrease in malondialdehyde (MDA) levels (SMD: −0.52 μmol/L; 95% CI: −0.89, −0.15; P = 0.006 , I2 = 71.3, P < 0.001 ) and increase in total antioxidant capacity (TAC) levels (WMD: 82.84 mmol/L; 95% CI: 19.80, 145.87; P = 0.006 , I2 = 92.7, P < 0.001 ). No significant effect was observed on glutathione (GSH). Conclusion. Our findings revealed that flaxseed oil supplementation might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults.

The evidence provided by meta‐analyses on the beneficial impacts of cinnamon supplementation on anthropometric indices are still conflicting. Present study’s aim was to evaluate the effects of cinnamon on obesity indices by an umbrella meta‐analysis. The electronic databases including Web of Science, PubMed, EMBASE, Scopus were systematically searched up to March 2021. Data for the effects of cinnamon on anthropometric indices were collected from the meta‐analyses. An umbrella meta‐analysis was carried out using a random‐effects model. The pooled effects of 7 meta‐analyses showed that cinnamon supplementation significantly reduced body weight (ES: −0.67 kg; 95% CI: −0.99, −0.35, p ˂ .001), body mass index (ES: −0.45 kg/m2; 95% CI: −0.57, −0.33, p ˂ .001) in comparison to control group. However, the effects of cinnamon on waist circumference (ES: −1.05 cm; 95% CI: −2.26, 0.15, p = .087) were not considerable. According to results, cinnamon could be suggested as a complementary weight loss agent. Favorable results were obtained at a dose of ≥3 g/day. In this study, a comprehensive study was performed on meta‐analyses performed on the effect of cinnamon on anthropometric indices. This study could be considered as a final conclusion about the effect of cinnamon on anthropometric indices. The results of this study showed that supplementation with cinnamon significantly reduces BMI and body weight. The impacts were greater in doses of ≥3 g/day and in PCOS patients. Practical applications In this study, a comprehensive study was performed on meta‐analyses performed on the effect of cinnamon on anthropometric indices. This study could be considered as a final conclusion about the effect of cinnamon on anthropometric indices. The results of this study showed that supplementation with cinnamon significantly reduces BMI and body weight. The impacts were greater in doses of ≥3 g/day and in PCOS patients.

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