Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Özkaya, Ahmet Kağan; Ciftci, Harun; Dayangac, Alpaslan; Çevrimli, Bekir Sıtkı; Ölçücü, Ali; Çelik, Sait

doi:10.5505/tjb.2013.29291

Cited by 8 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nobiletin has anti-atherosclerotic, anti-dyslipidemic, antihypertensive, anti-inflammatory, antioxidant, anti-resorptive, antithrombotic [47], anti-angiogenic, anti-carcinogenic, anti-dementia, cognitive impairment improving [48] and antitumor properties, and enhances adiponectin secretion [49]. Studies have shown that ellagic acid has anti-allergic, anticancer, anti-depressant, anti-diabetic, anti-inflammatory, antimalarial, antioxidant, anti-wrinkle, neuroprotective [50], anti-apoptotic, anti-atherogenic, anti-proliferative and chemo-preventive [51] activities. Silymarin is an anti-arthritic, anti-carcinogenic, anti-diabetic, anti-hypercholesterolemic, anti-inflammatory, anti-obesity, antioxidant, cardioprotective, gastroprotective, hepatoprotective, immunomodulatory, neuroprotective and neurotropic [52] agent.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition of <i>Tridax procumbens</i> Linn Leaves: Potential as a Functional Food

Ikewuchi¹,

Ikewuchi²,

Ifeanacho³

2015

FNS

View full text Add to dashboard Cite

The leaves of Tridax procumbens were screened for the presence of bioactive molecules. They had high flavonoids, alkaloids, hydroxycinnamates, tannins and phytosterols, moderate benzoic acid derivatives and lignans, and low carotenoids contents. Thirty nine known alkaloids (mainly akuammidine, 68.756%), twenty three known flavonoids (mainly 17.593% kaempferol and 12.538% (−)-epicatechin), five known carotenoids (mainly lutein, 62.608%), four known benzoic acid derivatives (mainly ferulic acid, 46.091%), two phytosterols (mainly stigmasterol, 80.853%) and six known lignans (mainly galgravin, 77.326%) were detected. Also detected were caffeic acid and tannic acid. The medicinal properties of the flavonoids, phytosterols, alkaloids, tannins, hydroxicinnamates, carotenoids, benzoic acid derivatives and lignans that were present in the leaves were discussed herein and proposed to be explored for their potential medicinal values. The great number of potentially active nutrients and their multifunctional properties make Tridax procumbens a perfect candidate for the production of health-promoting food and food supplements.

show abstract

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition of <i>Tridax procumbens</i> Linn Leaves: Potential as a Functional Food

Ikewuchi¹,

Ikewuchi²,

Ifeanacho³

2015

FNS

View full text Add to dashboard Cite

show abstract

“…In some studies, it has been reported that the Mn concentration decreases in rat liver exposed to Al. 41,42 In our study, we observed that the Zn and Mg concentration levels of group A decreased relatively compared to group C. Trace elements have important physiological functions in metabolism, and their abnormal usability causes serious negative effects. Trace elements, such as Cu, Zn, Fe, Mn, and Mg are essential co-factors for antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 56%

Protective Effects of 3-benzoyl-7-hydroxy Coumarin on Liver of Adult Rat Exposed to Aluminium Chloride

Özkaya

Türkan

2021

ACSi

View full text Add to dashboard Cite

In this study, the effects of 3-benzoyl-7-hydroxy coumarin molecule on mineral and antioxidant enzymes were investigated in rat liver exposed to oxidative stress with aluminium chloride (AlCl3). Adult male Wistar albino rats were divided into four groups as Control, Coumarin, AlCl3, and Coumarin + AlCl3. Coumarin at the dose of 10 mg/kg and AlCl3 at the dose of 8.3 mg/kg were administered for 30 days every other day. In AlCl3 group, malondialdehyde (MDA), iron (Fe), aluminium (Al) and copper (Cu) levels increased compared to the control group, while glutathione (GSH) level, glutathione S-transferase (GST), and carboxylesterase (Ces) enzyme activity levels decreased. In Coumarin + AlCl3 group, MDA, Fe, Al and Cu levels decreased with the effect of coumarin compared to AlCl3 group, while GSH level, and GST enzyme activity levels increased. According to our results, AlCl3 generates oxidative stress in rat livers, and we believe that 3-benzoyl-7-hydroxy coumarin has an ameliorative effect on antioxidant enzyme system, Al, Fe and Cu levels.

show abstract

“…In addition, vanillic acid is a flavoring, anthelmintic, hepatoprotective, immunemodulating, and anti-inflammatory agent (Khadem & Marles, 2010;Oksana et al, 2012). Ellagic acid is reported to have antioxidant, antimalarial, anti-inflammatory, antiallergic, antidiabetic, antiatherogenic, antiwrinkle, antidepressant, neuroprotective, antiapoptotic, anticancer, antiproliferative, and chemo-preventive activities (Dhingra & Chhillar, 2012;Özkaya et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Ifeanacho

Ikewuchi

2016

Food Science & Nutrition

View full text Add to dashboard Cite

The profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii was investigated using gas chromatography coupled with flame ionization detector. The leaves and stems had high flavonoids and benzoic acid derivatives content, and moderate levels of lignans and hydroxycinnamates. Twenty-eight known flavonoids were detected, which consisted mainly of kaempferol (41.93% in leaves and 47.97% in stems), (+)-catechin (17.12% in leaves and 16.11% in stems), quercetin (13.83% in leaves and 9.39% in stems), luteolin (7.34% in leaves and 7.71% in stems), and artemetin (6.53% in leaves and 4.83% in stems). Of the six known hydroxycinnamates detected, chlorogenic acid (80.79% in leaves and 87.56% in stems) and caffeic acid (18.98% in leaves and 12.30% in stems) were the most abundant, while arctigenin (77.81% in leaves and 83.40% in stems) and retusin (13.82% in leaves and 10.59% in stems) were the most abundant of the nine known lignans detected. Twelve known benzoic acid derivatives were detected, consisting mainly of ellagic acid (65.44% in leaves and 72.89% in stems), p-hydroxybenzoic acid (25.10% in leaves and 18.95% in stems), and vanillic acid (8.80% in leaves and 7.30% in stems). The rich phytochemical profile of the leaves and stems is an indication of their ability to serve as sources of nutraceuticals. K E Y W O R D Sflavonoids, hydroxycinnamates, lignans, Pandiaka heudelotii, phenolic acids

show abstract

Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Cited by 8 publications

References 30 publications

Phytochemical Composition of <i>Tridax procumbens</i> Linn Leaves: Potential as a Functional Food

Phytochemical Composition of <i>Tridax procumbens</i> Linn Leaves: Potential as a Functional Food

Protective Effects of 3-benzoyl-7-hydroxy Coumarin on Liver of Adult Rat Exposed to Aluminium Chloride

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Contact Info

Product

Resources

About

Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Cited by 8 publications

References 30 publications

Phytochemical Composition of &lt;i&gt;Tridax procumbens&lt;/i&gt; Linn Leaves: Potential as a Functional Food

Phytochemical Composition of &lt;i&gt;Tridax procumbens&lt;/i&gt; Linn Leaves: Potential as a Functional Food

Protective Effects of 3-benzoyl-7-hydroxy Coumarin on Liver of Adult Rat Exposed to Aluminium Chloride

Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector

Contact Info

Product

Resources

About

Phytochemical Composition of <i>Tridax procumbens</i> Linn Leaves: Potential as a Functional Food

Phytochemical Composition of <i>Tridax procumbens</i> Linn Leaves: Potential as a Functional Food