Protective Effects of 3-benzoyl-7-hydroxy Coumarin on Liver of Adult Rat Exposed to Aluminium Chloride

Özkaya, Ahmet Kağan; Türkan, Kenan

doi:10.17344/acsi.2020.6390

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…There is data [15,16] on coumarins' ability to suppress oxidative stress in the liver, which probably had a positive effect on the amino acid composition of this organ's tissues in the second and third groups. In addition, coumarin and coumarin-related compounds have also been found to be superior to ascorbic acid in terms of their antioxidant activity.…”

Section: Resultsmentioning

confidence: 99%

Changes in the biochemical composition of broiler body tissues when feeding with Bacillus cereus probiotic and coumarin

2022

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The article presents the study results on the effect of probiotic (Bacillus cereus IP 5832) and coumarin on the chemical and amino acid composition of body tissues when fed to broiler chickens together with the main diet. According to the experimental results, an increase in the concentration of dry matter by 0.27% and crude fat by 0.75% was found in the liver of young animals from the I experimental group compared to the control. At the end of the experiment, the broilers from the control group were inferior in the protein amount in the liver of the experimental poultry by 0.46%, 2.69 (P ≤0.05) and 1.16%. A similar pattern was observed when studying pectoral muscles' chemical composition on the 16 and 29 day study period; the accumulation of dry matter and protein in the poultry's pectoral muscles from the III experimental group by 0.7 and 0.71%; 0.89 and 1.21% relative to the control was revealed. Feeding broilers with a basic diet plus coumarin contributed to the accumulation of essential amino acids in their liver: lysine – by 1.05%, phenylalanine – by 0.41% and leucine-isoleucine by 0.63% relative to the control.

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Section: Resultsmentioning

confidence: 99%

Changes in the biochemical composition of broiler body tissues when feeding with Bacillus cereus probiotic and coumarin

2022

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“…Karaciğer dokuları (250 mg) %65'lik 5 mL HNO3 ile mikrodalgada parçalandı. Elde edilen çözeltideki mineral düzeyleri ICP-MS cihazında yapıldı (Özkaya & Türkan, 2021). Mineral düzeyleri ppb olarak verilmiştir.…”

Section: Karaciğer Dokusu Mineral Analizleriunclassified

Protective Effect of 3-Benzoyl-7-Hydroxy Coumarin on Lipid Peroxidation and Minerals on Rat Liver Tissues Induced Oxidative Stress with Lead Acetate

ÇİTİL¹

2022

Comm. J. Biol.

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Lead is a toxic substance and damages human metabolism. Coumarin-derived substances have many effects such as antioxidant, anticancer, and antibacterial ones. In this study, the effects of 3-benzoyl-7-hydroxy coumarin on rat liver tissues under oxidative stress with lead acetate were investigated. In the study, rats were divided into 4 groups. Control group (K), Coumarin group (KUM), Lead acetate group (P) and Coumarin+Lead acetate group (KUMP) groups were formed. Malondialdehyde (MDA), lead (Pb), iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) levels were determined in the liver tissues of the rats. MDA level of P group increased compared to the other groups. A decrease was observed in the KUMP group compared to the P group MDA level. While the Pb and Fe levels of the P group increased compared to the K group, the Pb and Fe levels of the KUMP group decreased compared to the P group. As a result, it is concluded that the 3-benzoyl-7-hydroxy coumarin molecule protects the high lipid peroxidation, lead, and iron metabolism caused by lead acetate in the liver.

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3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer’s disease rat model

Zeb,

Sharif,

Akhtar

et al. 2024

Inflammopharmacol

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Protective Effects of 3-benzoyl-7-hydroxy Coumarin on Liver of Adult Rat Exposed to Aluminium Chloride

Cited by 5 publications

References 45 publications

Changes in the biochemical composition of broiler body tissues when feeding with Bacillus cereus probiotic and coumarin

Changes in the biochemical composition of broiler body tissues when feeding with Bacillus cereus probiotic and coumarin

Protective Effect of 3-Benzoyl-7-Hydroxy Coumarin on Lipid Peroxidation and Minerals on Rat Liver Tissues Induced Oxidative Stress with Lead Acetate

3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer’s disease rat model

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