2003
DOI: 10.1590/s0102-09352003000200008
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Effects of desflurane, sevoflurane and isoflurane on pulmonary shunt in dogs during spontaneous ventilation

Abstract: The aim of this study was to compare the effects of desflurane, sevoflurane and isoflurane on pulmonary shunt in dogs during spontaneous ventilation. General anesthesia was induced in 30 healthy, adult, mongrel dogs by intravenous administration of propofol. The animals were separated into three groups of 10 dogs each and submitted to general inhalation anesthesia with 1.5 MAC of desflurane (G1), sevoflurane (G2) and isoflurane (G3). Arterial blood was collected by puncture of the right femoral artery, and mix… Show more

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Cited by 4 publications
(3 citation statements)
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“…(26) Using 0.08 mL/kg, other authors (12) registered shunt values of up to 35%. Those authors also demonstrated the decrease in and the stabilization of PaO 2 in the first 30 min, this condition persisting for 4 h. Another group of authors (27) found lower, basal fractions of Qs/Qt than those found in our study, approximately 15-20%. The dose used in the present study (0.15 mL/kg) explains the high Qs/Qt levels found.…”
Section: Resultssupporting
confidence: 68%
“…(26) Using 0.08 mL/kg, other authors (12) registered shunt values of up to 35%. Those authors also demonstrated the decrease in and the stabilization of PaO 2 in the first 30 min, this condition persisting for 4 h. Another group of authors (27) found lower, basal fractions of Qs/Qt than those found in our study, approximately 15-20%. The dose used in the present study (0.15 mL/kg) explains the high Qs/Qt levels found.…”
Section: Resultssupporting
confidence: 68%
“…Por outro lado, deve-se salientar que os valores médios obtidos em M0, em ambos os grupos, apresentaram-se discretamente acima dos valores considerados normais, demostrando que o desfluorano promove alteração na PaCO 2 , produzindo médias elevadas, provavelmente devido a sua ação depressora sobre o sistema respiratório (CLARKE, 1999;SANTOS, 2000) e ao concomitante aumento do shunt pulmonar promovido pelo agente volátil (NUNES et al, 2003).…”
Section: Discussionunclassified
“…A administração do agente halogenado produz aumento da atividade simpática, a qual atinge o pico máximo decorridos 5 minutos de exposição ao fármaco (PACENTINE et al, 1995).…”
Section: Introductionunclassified