Effects of copper and vitamin B-6 deficiency on taste sensitivity in the rat: A signal detection analysis

Brosvic, Gary M.; Hecht, Gerald S.

doi:10.1016/0031-9384(89)90100-5

Cited by 12 publications

(4 citation statements)

References 46 publications

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“…This adjustment is extremely important in that it prevents response biases from artificially inflating hit rates. Another psychophysical measure, the sensitivity index (SI; Frey & Colliver, 1973), is a nonparametric analog of d ′, which is a measure derived from signal detection theory (Gescheider, 1997; Green & Swets, 1966) and has been used to assess performance in taste detection tasks in rats (e.g., Brosvic & Hecht, 1989). Because these measures are based on different theoretical models, we wanted to confirm that any effects that our manipulations had on NaCl sensitivity were not idiosyncratic to the method used to measure performance.…”

Section: Methodsmentioning

confidence: 99%

Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

Kopka¹,

Spector²

2001

Behavioral Neuroscience

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Chorda tympani nerve (CT) transection (CTX) raises sodium chloride (NaCl) taste detection threshold, but the effect of CT regeneration on NaCl threshold is unknown. This experiment examined whether CT regeneration supports normal NaCl threshold in the rat. Thresholds were measured with a 2-lever operant procedure. Thresholds increased more than 1 order of magnitude after CTX regardless of recovery period length. Postsurgical thresholds in rats with regenerated CTs did not differ from presurgical values. Stimulus adulteration with amiloride raised thresholds in rats with intact or regenerated CTs by about 1 order of magnitude but did not raise thresholds beyond postsurgical levels in rats with transected CTs. Thus, the regenerated CT supports normal NaCl threshold, which is raised by amiloride. Because thresholds remained elevated 62 days after CTX when regeneration was prevented, compensatory processes alone cannot support normal NaCl threshold.

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Section: Methodsmentioning

confidence: 99%

Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

Kopka¹,

Spector²

2001

Behavioral Neuroscience

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“…Reagent-grade aqueous solutions of quinine sulfate and HCl at molar concentrations from 5 × 10 −7 to 5 × 10 −4 were also used. The molar concentrations of the tastants permitted comparison with results of the detection performance of normal and control animals tested previously (see Brosvic & Hecht, 1989; Brosvic et al, 1991; Brosvic & Hoey, 1990a, 1990b). Triple-deionized water served as the solvent for all solutions, the S−stimulus, and reinforcement.…”

Section: Methodsmentioning

confidence: 99%

Influences of hypothyroidism on the taste detection performance of rats: A signal detection analysis.

Brosvic¹,

Doty²,

Rowe³

et al. 1992

Behavioral Neuroscience

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The influences of hypothyroidism on behavioral measures of the taste function in male and female Long-Evans rats were determined. Experimental rats' preferences for and ability to detect NaCl, HCl, sucrose, and quinine sulfate were examined before, during, and after 9 weeks of maintenance on 0.1% propylthiouracil (PTU), an agent that produces marked hypothyroidism, with similar determinations made for control animals. Despite significant decreases in PTU-treated rats' serum triiodothyronine (T3) and thyroxin (T4), there were no changes in sensitivity or responsivity to the target tastants. However, altered preferences for NaCl, HCl, and quinine sulfate were observed for PTU-treated rats; elevated consumption of HCl and quinine sulfate was present at the end of the study when serum T3 and T4 had returned to near-baseline levels. The data confirm observations that PTU-induced hypothyroidism alters rats' taste preference behavior.

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“…Pyridoxine deficiency causes arteriosclerosis, fatty liver, and convulsions in monkeys 8 ; weakness, growth retardation, and convulsions in chickens 9 ; and neutropenia, 10 xanthuria, convulsions, 11,12 and seborrheic dermatitis 13,14 in humans, but has not been observed to have any effect on reproduction 15 or taste sensitivity 16 in the rat. The only neurological observations have been abnormal gait in pigs 17 and "sensory neuritis" in 3 of 50 people 14 in a short-term study of B 6 dietary deficiency.…”

mentioning

confidence: 97%

Experimental Model of Pyridoxine (B6) Deficiency-Induced Neuropathy

Dellon¹,

Dellon²,

Tassler³

et al. 2001

Annals of Plastic Surgery

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A pyridoxine (B6) dietary deficiency was studied in female adult Sprague-Dawley rats by hind-limb walking-track analysis. Serum levels of pyridoxine and three metabolites were quantified by high-pressure liquid chromatography with fluorescence measurement. Morphometric analysis of the sciatic and posterior tibial nerves (from within the tarsal tunnel) was performed after 1 year on a diet deficient in vitamin B6. The B6-deficient rats developed abnormal walking-track patterns by 8 months, and these track parameters were different from age- and sex-matched normal diet control rats at the p < 0.05 level. Adding B6 at 10 parts per million to the diet then partially corrected these parameters, whereas the addition of 30 parts per million B6 corrected the abnormal pattern completely. Serum pyridoxal concentration correlated with the functional parameters, dropping from a mean of 115 mg per liter to 39.5 mg per liter (p < 0.05), and correcting with the B6 additive. Morphometric analysis demonstrated that the B6-deficient nerve from the tarsal tunnel had a decreased nerve fiber density (p < 0.001), with a normal total myelinated nerve fiber number, and an increased axon-to-myelin ratio (p < 0.003). It is concluded that a diet totally deficient in vitamin B6 results in a peripheral neuropathy.

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Effects of copper and vitamin B-6 deficiency on taste sensitivity in the rat: A signal detection analysis

Cited by 12 publications

References 46 publications

Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

Influences of hypothyroidism on the taste detection performance of rats: A signal detection analysis.

Experimental Model of Pyridoxine (B6) Deficiency-Induced Neuropathy

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