Influences of hypothyroidism on the taste detection performance of rats: A signal detection analysis.

Brosvic, Gary M.; Doty, Richard L.; Rowe, M. Michelle; Harron, Amy; Kolodiy, Nicholas

doi:10.1037/0735-7044.106.6.992

Cited by 18 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, we cannot completely exclude the possibility of Fos induction by fastingrelated metabolic changes, which could be different between the euthyroid and hypothyroid rats. PTU treatment in rats altered preference taste behavior independent of hypothyroidism (6). In the present study, the body weight increase of the PTU-treated rats was smaller than control rats.…”

Section: Discussionmentioning

confidence: 57%

Hypothyroidism increases Fos immunoreactivity in cholinergic neurons of brain medullary dorsal vagal complex in rats

Yuan¹,

Yang²

2005

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Hypo-or hyperthyroidism is associated with autonomic disorders. We studied Fos expression in the medullary dorsal motor nucleus of the vagus (DMV), nucleus tractus solitarii (NTS), and area postrema (AP) in four groups of rats with different thyroid states induced by a combination of drinking water and daily intraperitoneal injection for 1-4 wk: 1) tap water and vehicle; 2) 0.1% propylthiouracil (PTU) and vehicle; 3) PTU and thyroxine (T 4; 2 g/100 g); and 4) tap water and T 4 (10 g/100 g). The numbers of Fos immunoreactive (IR) positive neurons in the DMV, NTS, and AP were low in euthyroid rats but significantly higher in the 4-wk duration in hypothyroid rats, which were prevented by simultaneous T4 replacement. Hyperthyroidism had no effect on Fos expression in these areas. There were significant negative correlations between T4 levels and the numbers of Fos-IRpositive neurons in the DMV (r ϭ Ϫ0.6388, P Ͻ 0.008), NTS (r ϭ Ϫ0.6741, P Ͻ 0.003), and AP (r ϭ Ϫ0.5622, P Ͻ 0.004). Double staining showed that Fos immunoreactivity in the DMV of hypothyroid rats was mostly localized in choline acetyltransferase-containing neurons. Thyroid hormone receptors ␣1 and ␤2 were localized in the observed nuclei. These results indicate that thyroid hormone influences the DMV/NTS/AP neuronal activity, which may contribute to the vagal-related visceral disorders observed in hypothyroidism. thyroid hormone; dorsal motor nucleus of the vagus; nucleus tractus solitarii; vagus nerve; area postrema HYPOTHYROIDISM IS A PREVALENT DISEASE worldwide and has a high incidence in elderly patients with nonthyroidal disease (3, 39). Extensive cardiovascular, gastrointestinal (GI), and metabolic disorders, such as sinus bradycardia, altered GI secretion and motility, and hyperlipidemia are the main clinical symptoms of hypothyroidism. These symptoms indicate autonomic dysfunction with a relative vagal dominance (43, 44) and correlate to increased mortality from cardiovascular and cerebrovascular diseases in those with a history of overt or subclinical thyroid disorders (29, 39). How thyroid hormone regulates vagal activities, particularly the central mechanism, is still poorly understood.On the basis of solidly established physiological role of medullary thyrotropin-releasing hormone (TRH)-containing vagal regulatory pathways in the central regulation of GI functions (47), we recently revealed that feedback regulation of TRH gene expression by thyroid hormone in the medullary raphe pallidus (Rpa), raphe obscurus (Rob), and parapyramidal region (PPR) may contribute to hypothyroidism-induced autonomic disorders (49 -52). TRH-containing projections arising from these nuclei innervate the dorsal vagal complex (DVC) (20) and the sympathetic motor neurons in the intermediolateral cell column of the spinal cord (40). Our previous studies showed that hypothyroidism increases TRH mRNA levels in the Rpa, Rob, and PPR and induces Fos expression, a widely accepted parameter indicating brain neuronal activation, in the TRH-synthesizing neurons in these nucl...

show abstract

Section: Discussionmentioning

confidence: 57%

Hypothyroidism increases Fos immunoreactivity in cholinergic neurons of brain medullary dorsal vagal complex in rats

Yuan¹,

Yang²

2005

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Apparently, patients with BMS are affected by dysgeusia, a phenomenon that occurs frequently with tyrosine-kinase inhibitors [131]. Thyroid hormones have been shown to influence the maturation and specialisation of the taste buds [132], and it has been speculated that hypothyroidism could therefore lead to a reduction in taste. Other investigators [133] have suggested a dysfunction of the nigrostriatal dopaminergic pathway that may account for the development of BMS.…”

Section: Pathophysiology Of Selected Side-effects (Involved Targets) mentioning

confidence: 99%

Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors

Schmidinger

2013

European Journal of Cancer Supplements

103

View full text Add to dashboard Cite

“…Some patients, in addition to the sensation of burning, also present alterations in taste ( 26 ), this happens more frequently when there are thyroid alterations ( 20 ), in which, due to latent or subclinical hypothyroidism, they are more predisposed to dysgeusia or ghost tastes ( 15 ). Thyroid hormones are related to the maturation and specialization of the taste buds ( 14 ). Braud et al ( 27 ) in their study showed altered taste sensitivity in BMS patients, with increased thresholds of fungiform and foliate taste buds.…”

Section: Discussionmentioning

confidence: 99%

“…The thyroid gland secretes triiodothyronine (T3) and thyroxine (T4) hormones that play an important role in tissue development and metabolism, as well as in the regulation of numerous functions and processes of the nervous system ( 13 ). Additionally, thyroid hormones have been shown to play a role in the maturation and specialization of taste buds ( 14 ). Therefore, the deficiency of these hormones can play a role in dysgeusia ( 15 ) and in peripheral/central neuropathies ( 13 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Role of thyroid hormones in burning mouth syndrome. Systematic review

Egido-Moreno¹,

Valls-Roca-Umbert²,

Pérez‐Sayáns³

et al. 2023

Med Oral

View full text Add to dashboard Cite

Background: Burning mouth syndrome is an idiopathic condition characterized by burning pain in a normalappearing oral mucosa lasting at least four to six months. In the case of secondary burning mouth syndrome is associated with local or systemic factors (such as thyroid disorders) that can cause these symptoms. The aim of this review was to study the relationship between thyroid disorders and burning mouth syndrome. Material and Methods: The present study followed the PRISMA guidelines. An electronic search strategy was developed for PubMed/Medline, Scopus and Cochrane. The following combination of keywords and Boolean operators were used: Thyroid AND burning mouth; Thyroid AND burning mouth syndrome; Hypothyroidism AND burning mouth; Hypothyroidism AND burning mouth syndrome; Hyperthyroidism AND burning mouth; Hyperthyroidism AND burning mouth syndrome. The results were processed by existing free software in https:// www.graphpad.com/. To evaluate the association of the categorical variables we used the Fisher test at a level of significance of p-value ≤ 0,05. As a primary summary measure the Odds Ratio (OR) has been used. To analyze the risk of bias the guidelines of the GRADE guide were used and the grade of evidence was analyzed by the guide of Joanna Briggs Institute: Levels of Evidence and Grades of Recommendations. Results: After applying the inclusion and exclusion criteria, 5 studies were selected for review. The Chi-square was 10.92 and the Odds Ratio was 3.31 with respect to TSH values with p <0.0001 (Fisher's test). The population of patients with TSH alterations is increased in 80.49% and decreased in 19.51%. Conclusions: It can be concluded that thyroid hormone abnormalities are a factor in secondary burning mouth syndrome; specially in patients with hypothyroidism.

show abstract

Influences of hypothyroidism on the taste detection performance of rats: A signal detection analysis.

Cited by 18 publications

References 27 publications

Hypothyroidism increases Fos immunoreactivity in cholinergic neurons of brain medullary dorsal vagal complex in rats

Hypothyroidism increases Fos immunoreactivity in cholinergic neurons of brain medullary dorsal vagal complex in rats

Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors

Role of thyroid hormones in burning mouth syndrome. Systematic review

Contact Info

Product

Resources

About