2001
DOI: 10.1037/0735-7044.115.5.1073
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Abstract: Chorda tympani nerve (CT) transection (CTX) raises sodium chloride (NaCl) taste detection threshold, but the effect of CT regeneration on NaCl threshold is unknown. This experiment examined whether CT regeneration supports normal NaCl threshold in the rat. Thresholds were measured with a 2-lever operant procedure. Thresholds increased more than 1 order of magnitude after CTX regardless of recovery period length. Postsurgical thresholds in rats with regenerated CTs did not differ from presurgical values. Stimul… Show more

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Cited by 21 publications
(37 citation statements)
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References 89 publications
(150 reference statements)
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“…Hamsters that have successfully acquired a conditioned taste aversion to NaCl subsequently fail to avoid the salt solution after CT transection but can reacquire the aversion on regeneration of the nerve (3). In rats, CT transection produces an increase in NaCl detection threshold of Ͼ1 order of magnitude and impairs the ability to discriminate NaCl from KCl, with sensitivity and salt discriminability returning to presurgical levels once the CT has regenerated (15,16). Moreover, in contrast to CT-transected rats, animals with regenerated CTs are just as sensitive to the performance-disrupting effects of amiloride treatment on NaCl detectability as intact rats (16).…”
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confidence: 96%
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“…Hamsters that have successfully acquired a conditioned taste aversion to NaCl subsequently fail to avoid the salt solution after CT transection but can reacquire the aversion on regeneration of the nerve (3). In rats, CT transection produces an increase in NaCl detection threshold of Ͼ1 order of magnitude and impairs the ability to discriminate NaCl from KCl, with sensitivity and salt discriminability returning to presurgical levels once the CT has regenerated (15,16). Moreover, in contrast to CT-transected rats, animals with regenerated CTs are just as sensitive to the performance-disrupting effects of amiloride treatment on NaCl detectability as intact rats (16).…”
mentioning
confidence: 96%
“…In rats, CT transection produces an increase in NaCl detection threshold of Ͼ1 order of magnitude and impairs the ability to discriminate NaCl from KCl, with sensitivity and salt discriminability returning to presurgical levels once the CT has regenerated (15,16). Moreover, in contrast to CT-transected rats, animals with regenerated CTs are just as sensitive to the performance-disrupting effects of amiloride treatment on NaCl detectability as intact rats (16). These findings suggest that regeneration of the CT leads to normal recovery of salt taste in rodents.…”
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confidence: 97%
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“…Interestingly, the performance of Sham-Int rats was similar to that of Sham animals, despite testing with concentrations that were 1.0 log 10 unit lower (P Ͼ 0.05). This group was included as a control for a likely attenuation in stimulus intensity that occurs after CTx (28,46,58). We lowered the stimulus concentrations by a log unit during postsurgical testing in a subset of rats subjected to sham surgery to test whether the initial drop in performance following nerve transection could have been simply due to a weakened stimulus.…”
Section: Methodsmentioning
confidence: 99%
“…Behavioral studies using rodent models have shown that the chorda tympani (CT) nerve, a branch of the seventh cranial nerve that provides the sole innervation of taste receptor cells in the anterior tongue, is necessary for normal taste-guided behavior related to salts. Both sodium detection and salt discrimination are severely affected by CT transection (CTx) (18,27,28,45,54,58,60). The behavioral findings are not surprising, given that the CT is highly responsive to salts (2,37,38,40,41) and incorporates a sodium-specific signal via a subpopulation of fibers thought to be the basis for NaCl vs. KCl discriminability, called N-fibers or sodium specialists (8,15,30,37).…”
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confidence: 99%