2001
DOI: 10.1097/00000637-200108000-00008
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Abstract: A pyridoxine (B6) dietary deficiency was studied in female adult Sprague-Dawley rats by hind-limb walking-track analysis. Serum levels of pyridoxine and three metabolites were quantified by high-pressure liquid chromatography with fluorescence measurement. Morphometric analysis of the sciatic and posterior tibial nerves (from within the tarsal tunnel) was performed after 1 year on a diet deficient in vitamin B6. The B6-deficient rats developed abnormal walking-track patterns by 8 months, and these track parame… Show more

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Cited by 16 publications
(6 citation statements)
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References 30 publications
(27 reference statements)
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“…Rats receiving a diet deficient in pyridoxine for one year developed abnormal walking-track patterns, however, when these rats received pyridoxine they partially recovered [301].…”
Section: The Role Of Trace Elements and Micronutrients In Agingmentioning
confidence: 96%
“…Rats receiving a diet deficient in pyridoxine for one year developed abnormal walking-track patterns, however, when these rats received pyridoxine they partially recovered [301].…”
Section: The Role Of Trace Elements and Micronutrients In Agingmentioning
confidence: 96%
“…Dietary deficiency of pyridoxine caused peripheral neuropathy in adult rats (Root and Longenecker, 1973; Dellon et al, 2001). Axonal abnormalities were associated with oligodendrocyte adaxonal ingrowths, a phenomenon common to beginning axonopathies in which the ensheathing cell sequesters and selectively removes effete and degenerate materials from the axon (Spencer and Thomas, 1974).…”
Section: 0 Vitamin Deficiency Chemicals and Neurological Diseasementioning
confidence: 99%
“…A common hallmark of these neuropathies are the structural and functional alterations of the myelin sheath and axons in response to a metabolic dysfunction. Few animal models have been developed to study alcoholic or uraemic neuropathy [152][153][154][155] and neuropathy induced by pyridoxine or thiamine deficiency [156][157][158] . In accordance with their frequency and severity, diabetic neuropathies are the most studied diseases among all the PNS pathologies [for a general review, see 159 ].…”
Section: Metabolic Neuropathiesmentioning
confidence: 99%