Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

Elkhalifa, Ahmed Mohammed Elnour

doi:10.15537/smj.2018.9.22630

Cited by 13 publications

(17 citation statements)

References 17 publications

(17 reference statements)

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“…According to our findings, the platelet count mean values and multiple linear regression showed a statistically significant decrease among Tombak users compared tonon-Tombak users. Similar results in previous studies were reported with significantly lower platelet counts in chewing tobacco users, Shisha smoking, and heavier chronic smokers than non-smokers [ 21 ]. A study conducted by Oaikhena et al [ 24 ] showed that the tobacco snuff could induce platelet count reduction among adult Wistar rats.…”

Section: Discussionsupporting

confidence: 91%

“…The study results indicated that the study population was entirely male. Oral Tombak SLT use in Sudan is a male-dominant habit, and females normally did not use Tombakor smoke cigarettes due to socio-cultural issues [ 7 , 21 ]. The age for the two groups varied from 20 to 65 years old, with a mean age of 39.46 ± 12.72 years old for the Tombak users group and 39.53 ± 12.21 years old for the non-Tombak users, and there was no statistically significant difference regarding age ( p -value 0.968).…”

Section: Resultsmentioning

confidence: 99%

“…However, our results, compared with other studies conducted among heavier smokers and SLT, shared nicotine substance habits with Tombak users. Hence, Tobacco smoking and SLT are known to bea public problem worldwide among youths and have a significant role in coagulation malfunctions [ 21 , 23 ]. The objective of our current study was to determine platelet counts (PTLs), prothrombin time (PT), activated partial thromboplastin time (APTT), and INR values among Sudanese who partake in dipping Tombak orally three times or more daily for three years or more and compared their results with the non-users ofTombak.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Oral Dipping Tombak Smokeless Tobacco on Coagulation Profile and Platelet Counts

et al. 2022

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The goal of this paper is to investigate the influence of oral dipping of Tombak Smokeless Tobacco (SLT) on prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio(INR) values, and platelet counts (PLTs), in Sudanese Tombak users. An analytical cross-sectional study was conducted at Kosti health insurance hospital, Sudan, in 2019. According to the inclusion and exclusion criteria, 100 adult users of oral Tombak for three or more years were chosen randomly as a study group. Another 100 matched healthy individuals who never used Tombak were randomly selected as a comparative group. Venous blood specimens were collected in ethylene diamine tetra-acetic acid (EDTA) containers for the PLT counts using the automated haematology analyser (Sysmex, Tokyo, Japan XK-21SYSMEX) and in trisodium citrate anti-coagulant containers for coagulation tests using a co-agulometer machine analyser. Our findings show a significant decrease in PLT count mean values in the Tombak users group (212.1 × 103/mm3 ± 74.3 × 103/mm3) compared with the non-taking Tombak group mean values (243.2 × 103/mm3 ± 83.0 × 103/mm3), (p < 0.006). Both PT and APTT were significantly prolonged in Tombak users (16.03 ± 1.22 s vs. 14.44 ± 0.557 s), p < 0.001 for PT, and (41.62 ± 7.28 s vs. 34.99 ± 4.02 s), (p < 0.001) for APTT. INR mean values were significantly longer in Tombak users (1.11 ± 0.096) vs. (1.07 ± 0.66; p < 0.001). Multiple linear regression analysis findings show a significant impact of the four investigated variables, including duration of taking Tombak, age, and frequency of taking Tombak per day (p < 0.001). In conclusion, using Tombak a Smokeless Tobacco (SLT) for a long period significantly affect Platelet counts and coagulation profile.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Influence of Oral Dipping Tombak Smokeless Tobacco on Coagulation Profile and Platelet Counts

et al. 2022

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“…Meanwhile, smoking may activate thrombopoietin which stimulates platelet production [20]. It had also been reported that smoking caused a hypercoagulable state of blood, which directly promoted thrombosis [21].…”

Section: Discussionmentioning

confidence: 99%

Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia

Liu¹,

Ge²,

Ruan³

et al. 2021

J. Cancer

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Background: Changes in platelet count (PLT) are strongly associated with patient survival and may be clinically indicative of certain underlying diseases. However, there were few studies on the prognosis of patients with cancer cachexia. Objective: The purpose of this study was to investigate the relationship between PLT and 1-year survival in patients with cancer cachexia. Methods: We performed a nested case-control study of data from a multicenter clinical study of cancer. There were 252 patients with cancer cachexia whose survival time was less than or equal to 1 year and 252 patients with cancer cachexia whose survival time was more than 1 year meeting the inclusion criteria. The mortality risk and the adjusted risk were estimated by logistic regression and displayed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: PLT was negatively correlated with 1-year overall survival (OS) of patients with cancer cachexia (increased per standard deviation (SD): OR = 1.29; 95% CI: 1.05-1.60; P = 0.018). The higher the PLT, the lower the OS of patients. When classified by dichotomy (D1 < 296×10 9 /L, D2 ≥ 296×10 9 /L), OS of patients in the D2 group was worse (OR = 2.18; 95% CI: 1.38-3.47; P = 0.001). When classified by quartile (Q1- Q3 < 305×10 9 /L, Q4 ≥ 305×10 9 /L), OS of patients in the Q4 group was poorer (OR = 1.82; 95% CI: 1.14-2.94; P = 0.013). In addition, patients with a low PLT (< 296×10 9 /L) and either a high total bilirubin (TBIL) (≥ 17.1 µmol/L) or a smoking history had poor 1-year survival. Based on our primary cohort study, we conducted a survival analysis of 3130 patients with cancer cachexia and found that OS was better in patients with low PLT (< 296×10 9 /L). Conclusion: PLT was negatively correlated with 1-year overall survival of patients with cancer cachexia.

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“…Moreover, positive linear correlation was found between the pack-years, reflecting the number of cigarettes smoked daily and the time of smoking, and NLR [ 53 , 55 ]. However, our study revealed the negative linear correlation with the number of cigarettes/day as well as duration of tobacco use and platelet and PLR values in GO group, which may be caused by nicotine-induced decreased thrombopoietic activity in smokers [ 56 ]. Smokers with GD who present higher values of WBC, neutrophil, eosinophil counts and NLR values can be easily identified during routine morphology check-up, and may benefit from preventive actions.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

Szydełko

Litwińczuk

Szydełko

et al. 2020

JCM

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Graves’ orbitopathy (GO) is an autoimmune disease with a chronic inflammatory background. Smoking behavior is the main environmental factor responsible for the transition of this major extra thyroidal manifestation of Graves’ disease (GD) from the subclinical to the overt form. Complete blood count-derived parameters are suggested to be novel inflammatory indices. The aim of this retrospective study was to investigate the association between neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte ratios (PLR) with selected clinical parameters and smoking status in 406 GD patients with (n = 168) and without GO (n = 238). The control group consisted of 100 healthy individuals. The activity of GO was graded according to Clinical Activity Score. Significantly higher white blood cells (WBC), neutrophil, and NLR (p < 0.05) values were observed in GD patients with GO compared with those without GO. PLR values were significantly higher in GO patients than in the controls. WBC (6.81 ± 1.56 vs. 5.70 ± 1.23) and neutrophils (3.89 ± 1.06 vs. 3.15 ± 0.95) count was higher in active GO patients than in those with inactive GO. Positive correlation (p < 0.05) between CAS score and WBC, neutrophil and monocyte count, and NLR was found. Smoking was associated with higher WBC (p = 0.040), neutrophil (p = 0.049), PLR (p = 0.032) values. Multivariate analysis revealed that WBC, NLR may be risk factors for GO development. WBC, neutrophil, NLR and PLR values seem to be useful tools in the assessment of inflammation in GD.

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Effects of cigarette smoking on coagulation screening tests and platelet counts in a Sudanese male adults population

Cited by 13 publications

References 17 publications

Influence of Oral Dipping Tombak Smokeless Tobacco on Coagulation Profile and Platelet Counts

Influence of Oral Dipping Tombak Smokeless Tobacco on Coagulation Profile and Platelet Counts

Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

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