Effects of chronic polychlorinated biphenyls exposure on growth and reproduction of second generation white-footed mice (Peromyscus leucopus)

Linzey, Alicia V.

doi:10.1007/bf01055152

Cited by 25 publications

(15 citation statements)

References 23 publications

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“…Experiments with rodents exposed to EDs have shown that the animals displayed a reduction in the number of germ cells, a decrease in the reproductive organ weights, a reduced number of implantation sites, embryo toxicity and reduced litter size [32][33][34]. Recently, we have observed that prenatal exposure of rats to low concentration of Aroclor 1254, a mixture of EDs, results in a perturbing effect on a battery of hypothalamic androgen metabolising enzymes involved in the control of sexual differentiation of the developing brain, namely aromatase and 5 alpha-reductase type1 and 2.…”

Section: Effect Of Eds On Reproduction and Developmentmentioning

confidence: 99%

Effects of Endocrine Disruptors on Developmental and Reproductive Functions

Brevini¹,

Zanetto²,

Cillo³

2005

curr drug targets immune endocr metabol disord

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Endocrine disruptors (EDs) are exogenous environmental molecules that may affect the synthesis, secretion, transport, metabolism, binding, action, and catabolism of natural hormones in the body. EDs may thus interact with the endocrine system of animals and humans and can exert this effect even when present in minute amounts. EDs have adverse impacts on a number of developmental functions in wildlife and humans. Critical periods of urogenital tract and nervous system development in-utero and during early post-natal life are especially sensitive to hormonal disruption. Furthermore a wide range of hormone-dependent organs (pituitary gland, hypothalamus, reproductive tract) are targets of EDs disrupting effects in adult subjects, possibly resulting in cell transformation and cancer. At present about 60 chemicals have been identified and characterized as EDs and belong to three main groups: (a) synthetic compounds utilized in industry, agriculture and consumer products; (b) synthetic molecules used as pharmaceutical drugs and (c) natural chemicals found in human and animal food (phytoestrogens). In the present review we will give special attention to the family of Polychlorinated biphenyls (also indicated as PCBs) because of their persistence in the environment, ability to concentrate up the food chain, continued detection in environmental matrices, and ability to be stored in the adipose tissue of animals as well as humans. The detrimental effects of these compounds, and of EDs more in general, on health and reproduction will be discussed, presenting experimental data aimed at understanding the molecular mechanisms involved in their action.

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Section: Effect Of Eds On Reproduction and Developmentmentioning

confidence: 99%

Effects of Endocrine Disruptors on Developmental and Reproductive Functions

Brevini¹,

Zanetto²,

Cillo³

2005

curr drug targets immune endocr metabol disord

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show abstract

“…However, to date which biological functions are affected is not yet delineated. Rodents exposed to PCBs have experienced a reduction in the germ cell number, a decrease in the reproductive organ weights, a reduced number of implantation sites, embryotoxicity and reduced litter size [38][39][40]. Reproductive disorders have also been observed in non-human primates.…”

Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupters on ovarian function and embryonic development

Gandolfi

Pocar²,

Brevini

et al. 2002

Domestic Animal Endocrinology

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“…Decreased progesterone may reduce the implantation rate and alter the maintenance of corpus luteum. Rodents exposed to PCBs experience a reduced number of implantation sites, embryo toxicity, and reduced litter size (d’Argy et al 1987; Linzey 1988; Ronnback and de Rooij 1994). PCB/PCDF-induced subfertility might be caused by interfered ovarian function, ovulation, corpus luteum maintenance, implantation, and embryo development.…”

Section: Discussionmentioning

confidence: 99%

Exposure to a Mixture of Polychlorinated Biphenyls and Polychlorinated Dibenzofurans Resulted in a Prolonged Time to Pregnancy in Women

Yang

Wang

Chen

et al. 2008

Environ Health Perspect

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BackgroundPolychlorinated biphenyls (PCBs), dibenzofurans (PCDFs), and dibenzodioxins (PCDDs) may affect the female reproductive system in animals and humans. In 1978–1979, a mass poisoning occurred in central Taiwan due to PCB/PCDF-contaminated cooking oil; this incident was called Yucheng (“oil disease” in Chinese).ObjectiveThe purpose of our study was to determine whether PCB/PCDF exposure affected fertility in exposed women.MethodsAfter the event, we followed the exposed individuals and a reference group who were sex-, age-, and community-matched. In 2003, we obtained fertility histories from Yucheng and reference women by telephone interview. We used Kaplan–Meier survival curves and multivariable Cox regression to compare time to pregnancy (TTP) between Yucheng and reference women, and we performed multiple logistic regression to determine whether PCB/PCDF exposure caused infertility.ResultsIn total, 412 women responded, with a median TTP of 4 months in Yucheng women and 3 months in reference women (p = 0.019). After adjusting for confounders by Cox regression, we found a fecundability ratio of 0.90 [95% confidence interval (CI), 0.80–1.00] for Yucheng women. Among the 408 women who had noncontraceptive sexual activity for > 12 months, 19.7% of Yucheng women and 9.7% of reference women did not become pregnant (i.e., they were infertile). After we adjusted for confounders by logistic regression, the infertility odds ratio was 2.34 (95% CI, 1.23–4.59) for Yucheng women compared with the reference group.ConclusionsWe found prolonged TTP and reduced fertility among women previously exposed to PCBs/PCDFs. Because of the limited sample size and the relatively small decrease in the fertility rate, these effects require cautious interpretation and further investigation for confirmation.

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Effects of chronic polychlorinated biphenyls exposure on growth and reproduction of second generation white-footed mice (Peromyscus leucopus)

Cited by 25 publications

References 23 publications

Effects of Endocrine Disruptors on Developmental and Reproductive Functions

Effects of Endocrine Disruptors on Developmental and Reproductive Functions

Impact of endocrine disrupters on ovarian function and embryonic development

Exposure to a Mixture of Polychlorinated Biphenyls and Polychlorinated Dibenzofurans Resulted in a Prolonged Time to Pregnancy in Women

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