Impact of endocrine disrupters on ovarian function and embryonic development

Bovine Abortifacient and Teratogenic Toxins

“…69 Endocrine-disrupting compounds Endocrine-disrupting compounds are a diverse group of compounds, natural and synthetic, that can potentially modulate or disrupt hormone homeostasis. 71,72 Common synthetic endocrine disrupters include pesticides (DDT and organophosphorus pesticides), herbicides, fungicides, plasticizers, polystyrenes, polybrominated biphenyls and polychlorinated biphenyls (PBBs and PCBs), polychlorinated dibenzodioxins, and alkylphenolic compounds. 71,73 These compounds are typically present in the environment at low concentrations but are persistent and have the potential to exert adverse effects on humans and animals.…”

“…71,72 Common synthetic endocrine disrupters include pesticides (DDT and organophosphorus pesticides), herbicides, fungicides, plasticizers, polystyrenes, polybrominated biphenyls and polychlorinated biphenyls (PBBs and PCBs), polychlorinated dibenzodioxins, and alkylphenolic compounds. 71,73 These compounds are typically present in the environment at low concentrations but are persistent and have the potential to exert adverse effects on humans and animals. Exposure to endocrine disrupters may in some cases contribute to, or directly cause, infertility, pregnancy loss, intrauterine fetal death, and fetal teratogenic effects.…”

“…The effects of endocrinedisrupting compounds can have impacts on developing fetuses and postnatal offspring by affecting different biochemical pathways. 71 Synthetic endocrine disrupters are suspected to have potential reproductive effects in a number of animal species but clinical studies are limited.…”

“…PCBs either alone or in combination can impair normal oocyte maturation. 71 PCBs act as synthetic endocrine disrupters that affect steroid synthesis by increasing the activity of cytochrome P450 via their high affinity for estradiol and/or arylhydrocarbon receptors. Select PCBs have been shown to increase the secretion of oxytocin from the bovine ovary and PGF 2α from uterine endometrial cells.…”

Malformações congênitas em regiões de monocultivo no estado de Minas Gerais, Brasil

“…32 Nos últimos tempos têm crescido o número de óbitos relacionados à MC, o que torna a prevenção e a investigação sobre os fatores de risco associados a esse desfecho de grande relevância para a saúde pública. 33,34,35 Neste contexto, o presente estudo tem como objetivo analisar a distribuição temporal das MFC observadas no estado de Minas Gerais no período de 1994 a 2014, assim como avaliar a natureza da correlação existente entre a tendência observada e o volume de agrotóxicos considerados como disruptores endócrinos.…”