Effects of caloric restriction on retinal aging and neurodegeneration

Adornetto, Annagrazia; Morrone, Luigi Antonio; Satriano, Andrea; Laganà, Maria Luisa; Licastro, Ester; Nucci, Carlo Alberto; Corasaniti, Maria Tiziana; Tonin, Paolo; Bagetta, Giacinto; Russo, Rossella

doi:10.1016/bs.pbr.2020.07.005

Cited by 4 publications

(3 citation statements)

References 138 publications

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“…In retinal aging, CR protects the structural and functional integrity of retinal ganglion cells by facilitating cellular autophagy, which improves the progression of glaucoma that occurs commonly in aging people (Adornetto et al, 2020). In regard to age-related changes in retinal tissues, CR has been shown to reduce certain metabolites, such as glutathione and ascorbic acid levels (Li et al, 2003), exerting a protective function against retina degeneration.…”

Section: Retinal Agingmentioning

confidence: 99%

Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Zhang

Ding

et al. 2021

Front. Physiol.

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Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions.

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Section: Retinal Agingmentioning

confidence: 99%

Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Zhang

Ding

et al. 2021

Front. Physiol.

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“…Caloric restriction, described as decrease in nutrient intake without incurring malnutrition, is the most reproducible intervention shown to extend life span in a broad variety of organisms, ranging from yeast, worm, Drosophila , and mice [ 83 ]. CR also ameliorates several age-related diseases, including age-related malignancies [ 84 ], cardiovascular aging, neurodegenerative and other degenerative diseases such as macular degeneration [ 85 ], and age-dependent sensorineural hearing loss [ 86 ]. Furthermore, CR has been shown to improve health span in primates [ 11 ].…”

Section: Tor Signaling In Agingmentioning

confidence: 99%

TOR Signaling Pathway in Cardiac Aging and Heart Failure

2021

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Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, health span, and aging by modulating key cellular processes such as protein synthesis, autophagy, and mitochondrial function, mainly through its downstream substrates. Thus, the mTOR pathway regulates both physiological and pathological processes in the heart from embryonic cardiovascular development to maintenance of cardiac homeostasis in postnatal life. In this regard, the dysregulation of mTOR signaling has been linked to many age-related pathologies, including heart failure and age-related cardiac dysfunction. In this review, we highlight recent advances of the impact of mTOR complex 1 pathway and its regulators on aging and, more specifically, cardiac aging and heart failure.

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“…Finally, the importance of metabolic stress to the retinal ganglion cell loss seen in GON has been shown in animal model experiments [93 ▪▪ ]. For example, caloric restriction has been shown to decrease optic nerve degeneration in the DBA/2NNia mouse model of angle-closure glaucoma [94].…”

Section: Metabolic Syndrome and Glaucomatous Optic Neuropathymentioning

confidence: 99%

Metabolic syndrome and the aging retina

Roddy

2021

Current Opinion in Ophthalmology

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Purpose of reviewThis review explores metabolic syndrome (MetS) as a risk factor that accelerates aging in retinal neurons and may contribute to the neurodegeneration seen in glaucomatous optic neuropathy (GON) and agerelated macular degeneration (AMD). Recent findingsBoth animal model experiments and epidemiologic studies suggest that metabolic stress may lead to aberrant regulation of a number of cellular pathways that ultimately lead to premature aging of the cell, including those of a neuronal lineage. SummaryGON and AMD are each leading causes of irreversible blindness worldwide. Aging is a significant risk factor in the specific retinal neuron loss that is seen with each condition. Though aging at a cellular level is difficult to define, there are many mechanistic modifiers of aging. Metabolic-related stresses induce inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, alterations to the unfolded protein response, defects in autophagy, alterations to the microbiome, and deposition of advanced glycation end products that can all hasten the aging process. Due to the number of variables related to metabolic health, defining criteria to enable the study of risk factors at a population level is challenging. MetS is a definable constellation of related metabolic risk factors that includes enlarged waist circumference, dyslipidemia, systemic hypertension, and hyperglycemia. MetS has been associated with both GON and AMD and may contribute to disease onset and/or progression in each disease.

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Effects of caloric restriction on retinal aging and neurodegeneration

Cited by 4 publications

References 138 publications

Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

TOR Signaling Pathway in Cardiac Aging and Heart Failure

Metabolic syndrome and the aging retina

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