Metabolic syndrome and the aging retina

Roddy, Gavin W.

doi:10.1097/icu.0000000000000747

Cited by 13 publications

(18 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with LTG were further classified into 2 separate phenotypes that were based on metabolic phenotypes that tend to be clustered in a single patient. Phenotype 1 was defined as LTG patients with risk factors that comprise or are associated with metabolic syndrome: systemic hypertension, diabetes mellitus, peripheral vascular disease, coronary artery disease, or OSA, 6,46 without any characteristics of phenotype 2. Phenotype 2 was defined as LTG patients with Raynaud syndrome, migraine headache, anemia, or systemic hypotension without any of the criteria from phenotype 1.…”

Section: Data Source and Participantsmentioning

confidence: 99%

Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma

Funk

Hodge

Kohli

et al. 2021

Journal of Glaucoma

Self Cite

View full text Add to dashboard Cite

Précis: Multiple systemic vascular-associated conditions including systemic hypertension and hypotension, diabetes mellitus, migraine headache, peripheral vascular disease, Raynaud syndrome, and anemia were associated with low-tension glaucoma.Purpose: The purpose of this study was to identify systemic risk factors associated with low-tension glaucoma.Patients and Methods: A retrospective case-control study design was employed to identify patients seen at the Mayo Clinic Department of Ophthalmology between 2005 and 2015 with low-tension glaucoma and an age-matched and sex-matched control group, each containing 277 patients. Results:The low-tension glaucoma group had more myopic refractive errors (−1.6 vs. −1.0 D, P < 0.001), lower intraocular pressure (14.2 vs. 15.2 mm Hg, P < 0.001), and a higher cup-to-disc ratio (0.7 vs. 0.3, P < 0.001). The low-tension glaucoma group was significantly less likely to be obese (body mass index > 30, P = 0.03). This group had a significantly higher prevalence of systemic hypertension [odds ratio (OR): 1.64, P = 0.004], diabetes mellitus (OR: 3.01, P < 0.001), peripheral vascular disease (OR: 2.61, P = 0.009), migraine headache (OR: 2.12, P = 0.02), anemia (OR: 2.18, P = 0.003), systemic hypotension (OR: 4.43, P < 0.001), Raynaud syndrome (OR: 3.09, P = 0.05), and angiotensin-converting enzyme inhibitor (OR: 1.64, P = 0.01) or calcium channel blocker use (OR: 1.98, P = 0.004). After adjusting for systemic hypertension, calcium channel blocker use remained significant (OR: 1.70, P = 0.03). No significant difference was found between groups with respect to hyperlipidemia, obstructive sleep apnea, coronary artery disease, carotid stenosis, stroke, or statin, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, beta-blocker, or metformin use.Conclusions: Multiple vascular-associated conditions were associated with low-tension glaucoma including systemic hypertension, diabetes mellitus, peripheral vascular disease, migraine headache, Raynaud syndrome, anemia, systemic hypotension, and calcium channel blocker use. This study strengthens the evidence for the vascular hypothesis of low-tension glaucoma.

show abstract

Section: Data Source and Participantsmentioning

confidence: 99%

Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma

Funk

Hodge

Kohli

et al. 2021

Journal of Glaucoma

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metabolic syndrome is the deleterious systemic changes that develop as a consequence of high fat/sugar/salt diets, including insulin resistance and the build-up of “bad” low-density lipoprotein (LDL) cholesterol. Importantly, metabolic syndrome is also associated with accelerated aging and neurodegenerative disease, including in the retina ( Roddy, 2021 ). However, metabolism can be reprogrammed, and several studies have reported that healthy caloric restriction can slow down cellular aging and increase lifespan ( Finkel, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

Hanna

David

Touahri

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Vision commences in the retina with rod and cone photoreceptors that detect and convert light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative disease leads to visual impairment and blindness. Interventions now in development include transplanting photoreceptors, committed photoreceptor precursors, or retinal pigment epithelial (RPE) cells, with the latter protecting photoreceptors from dying. However, introducing exogenous human cells in a clinical setting faces both regulatory and supply chain hurdles. Recent work has shown that abnormalities in central cell metabolism pathways are an underlying feature of most neurodegenerative disorders, including those in the retina. Reversal of key metabolic alterations to drive retinal repair thus represents a novel strategy to treat vision loss based on cell regeneration. Here, we review the connection between photoreceptor degeneration and alterations in cell metabolism, along with new insights into how metabolic reprogramming drives both retinal development and repair following damage. The potential impact of metabolic reprogramming on retinal regeneration is also discussed, specifically in the context of how metabolic switches drive both retinal development and the activation of retinal glial cells known as Müller glia. Müller glia display latent regenerative properties in teleost fish, however, their capacity to regenerate new photoreceptors has been lost in mammals. Thus, re-activating the regenerative properties of Müller glia in mammals represents an exciting new area that integrates research into developmental cues, central metabolism, disease mechanisms, and glial cell biology. In addition, we discuss this work in relation to the latest insights gleaned from other tissues (brain, muscle) and regenerative species (zebrafish).

show abstract

“…Between geographical regions, AMD was less prevalent in Asia than in Europe and North America [ 2 ]. Increasing age and genetic factors play important roles in the development of AMD, while other risk factors, including smoking, obesity, a higher body mass index, and metabolic syndromes, such as dyslipidemia, hypertension, and hyperglycemia, are reported to be associated with higher prevalence, more progression, and increased severity of AMD [ 1 , 2 , 6 , 7 , 8 ]. AMD stems from accumulation of drusen, the lipoprotein-rich deposits underneath retinal pigment epithelium (RPE) with pigmentary changes and/ or thickened overlying Bruch’s membrane.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration

Liang

Hsu

et al. 2021

IJMS

View full text Add to dashboard Cite

Background: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Choroidal neovascularization (CNV) is the major pathologic feature of neovascular AMD. Oxidative damages and the ensuing chronic inflammation are representative of trigger events. Hydrogen gas (H2) has been demonstrated as an antioxidant and plays a role in the regulation of oxidative stress and inflammation. This experiment aimed to investigate the influence of H2 inhalation on a mouse model of CNV. Methods: Laser was used to induce CNV formation. C57BL/6J mice were divided into five groups: the control group; the laser-only group; and the 2 h, 5 h, and 2.5 h/2.5 h groups that received laser and H2 inhalation (21% oxygen, 42% hydrogen, and 37% nitrogen mixture) for 2 h, 5 h, and 2.5 h twice every day, respectively. Results: The severity of CNV leakage on fluorescence angiography showed a significant decrease in the H2 inhalation groups. The mRNA expression of hypoxia-inducible factor 1 alpha and its immediate downstream target vascular endothelial growth factor (VEGF) showed significant elevation after laser, and this elevation was suppressed in the H2 inhalation groups in an inhalation period length-related manner. The mRNA expression of cytokines, including tumor necrosis factor alpha and interlukin-6, also represented similar results. Conclusion: H2 inhalation could alleviate CNV leakage in a laser-induced mouse CNV model, and the potential mechanism might be related to the suppression of the inflammatory process and VEGF-driven CNV formation.

show abstract

Metabolic syndrome and the aging retina

Cited by 13 publications

References 125 publications

Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma

Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration

Contact Info

Product

Resources

About