Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Zhang, Li; Xu, Huachong; Ding, Ning; Li, Xue; Chen, Xiaoyin; Chen, Zhuangfei

doi:10.3389/fphys.2021.715443

Cited by 9 publications

(7 citation statements)

References 190 publications

(200 reference statements)

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“…92 Mild stress due to dietary restriction has shown benefits for lifespan, health span and brain health. [93][94][95] Our work demonstrates a similar phenomenon in the context of neurodegenerative disease and dendrite repair. Previous work has shown that activating the integrated stress response is beneficial in HD and ALS models.…”

Section: Moderate Stressors Have Been Associated With Benefits For Or...supporting

confidence: 67%

Dendrite injury, but not axon injury, triggers neuroprotection in Drosophila models of neurodegenerative disease

Prange,

Bhakta,

Sysoeva

et al. 2024

Preprint

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Dendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis. Dendrite degeneration can be modeled by expressing pathogenic polyglutamine disease transgenes in Drosophila neurons in vivo. Here, we show that we can protect against dendrite loss in neurons modeling neurodegenerative polyglutamine diseases through injury to a single primary dendrite branch. We find that this neuroprotection is specific to injury-induced activation of dendrite regeneration: neither injury to the axon nor injury just to surrounding tissues induces this response. We show that the mechanism of this regenerative response is stabilization of the actin (but not microtubule) cytoskeleton. We also demonstrate that this regenerative response may extend to other neurodegenerative diseases. Together, we provide evidence that activating dendrite regeneration pathways has the potential to slow or even reverse dendrite loss in neurodegenerative disease.

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Section: Moderate Stressors Have Been Associated With Benefits For Or...supporting

confidence: 67%

Dendrite injury, but not axon injury, triggers neuroprotection in Drosophila models of neurodegenerative disease

Prange,

Bhakta,

Sysoeva

et al. 2024

Preprint

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“…Indeed, reduced ECM synthesis is thought to contribute to exacerbated age-associated deficits in wound healing 41 and skin quality 42 concomitant with ageing. Saying this, reducing ECM deposition has been shown to contribute to the anti-hypertensive 43 and neuroprotective 44 effects of CR. Ultimately, how CR-mediated alterations in ECM organisation might alter sarcopenia and overall muscle health should be explored further.…”

Section: Discussionmentioning

confidence: 99%

Unravelling the Transcriptomic Symphony of Sarcopenia: Key Pathways and Hub Genes Altered by Muscle Ageing and Caloric Restriction Revealed by RNA Sequencing

Altab,

Merry,

Beckett

et al. 2024

Preprint

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Sarcopenia is a disease involving extensive loss of muscle mass and strength with age and is a major cause of disability and accidents in the elderly. Mechanisms purported to be involved in muscle ageing and sarcopenia are numerous but poorly understood, necessitating deeper study. Hence, we employed high-throughput RNA sequencing to explicate the global changes in protein-coding gene expression occurring in skeletal muscle with age. Caloric restriction (CR) is a proven prophylactic intervention against sarcopenia. Therefore, total RNA was isolated from the muscle tissue of both rats fed ad libitum and CR rats. Collected data were subjected to Gene Ontology, pathway, co-expression, and interaction network analyses. This revealed the functional pathways most activated by both ageing and CR, as well as the key "hub" proteins involved in their activation. RNA-seq revealed 442 protein-coding genes to be upregulated and 377 to be downregulated in aged muscle, compared to young muscle. Upregulated genes were commonly involved in protein folding and the immune response; meanwhile, downregulated genes were often related to developmental biology. CR was found to suppress 69.7% and rescue 57.8% of the genes found to be upregulated and downregulated in aged muscle, respectively. In addition, CR uniquely upregulated 291 and downregulated 304 protein-coding genes. Hub genes implicated in both ageing and CR included Gc, Plg, Irf7, Ifit3, Usp18, Rsad2, Blm and RT1-A2, whilst those exclusively implicated in CR responses included Alb, Apoa1, Ambp, F2, Apoh, Orm1, Mx1, Oasl2 and Rtp4. Hub genes involved in ageing but unaffected by CR included Fgg, Fga, Fgb and Serpinc1. In conclusion, this comprehensive RNA sequencing study highlighted gene expression patterns, hub genes and signalling pathways most affected by ageing in skeletal muscle. This data may provide the initial evidence for several targets for therapeutic interventions against sarcopenia.

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“…Caloric restriction (CR) extends the lifespan, improves health, and slows ARHL progression in older adults [101]. Furthermore, CR was shown to reduce the incidence of obesity, diabetes, and tumors [102]; protect neurons from neurodegenerative diseases [103]; and decrease inflammation and oxidative damage in aged brains, hearts, and livers in animal models [104]. Several studies have attempted to elucidate whether CR or dietary restriction (DR) can protect against age-related hearing loss in animal models [44,105,106].…”

Section: Low Sugar and Caloric Restriction Dietmentioning

confidence: 99%

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Chen

Tan

et al. 2022

Nutrients

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Background: The world’s age-related health concerns continue to rise. Audio-vestibular disorders, such as hearing loss, tinnitus, and vertigo, are common complaints in the elderly and are associated with social and public health burdens. Various preventative measures can ease their impact, including healthy food consumption, nutritional supplementation, and lifestyle modification. We aim to provide a comprehensive summary of current possible strategies for preventing the age-related audio-vestibular dysfunction. Methods: A PubMed, Embase, and Cochrane review databases search was conducted to identify the relationship between diet, lifestyle, and audio-vestibular dysfunction. “Diet,” “nutritional supplement,” “lifestyle,” “exercise,” “physical activity,” “tinnitus,” “vertigo” and “age-related hearing loss” were used as keywords. Results: Audio-vestibular dysfunction develops and progresses as a result of age-related inflammation and oxidative stress. Diets with anti-inflammatory and antioxidant effects have been proposed to alleviate this illness. A high-fat diet may induce oxidative stress and low protein intake is associated with hearing discomfort in the elderly. Increased carbohydrate and sugar intake positively correlate with the incidence of audio-vestibular dysfunction, whereas a Mediterranean-style diet can protect against the disease. Antioxidants in the form of vitamins A, C, and E; physical activity; good sleep quality; smoking cessation; moderate alcohol consumption; and avoiding noise exposure are also beneficial. Conclusions: Adequate diet or nutritional interventions with lifestyle modification may protect against developing audio-vestibular dysfunction in elderly individuals.

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Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Cited by 9 publications

References 190 publications

Dendrite injury, but not axon injury, triggers neuroprotection in Drosophila models of neurodegenerative disease

Dendrite injury, but not axon injury, triggers neuroprotection in Drosophila models of neurodegenerative disease

Unravelling the Transcriptomic Symphony of Sarcopenia: Key Pathways and Hub Genes Altered by Muscle Ageing and Caloric Restriction Revealed by RNA Sequencing

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

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