Effects of Ageing on Bone Mineral Composition and Bone Strength

Havaldar, Raviraj

doi:10.9790/0853-0131216

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…In the present study, we synthesized a 3D scaffold containing a combination of a carbon-based organic polymer, PU, and mineral components, nHA and decellularized bone particles (DBPs) (Geistlich), in such a way that the resulting scaffold consists of a complex nano-/macromatrix with malleable and mineral components. It has been suggested that, for the human trabecular and cortical bones taken together, the organic component ranges between 20% and 30% of the mineral weight; thus, a scaffold with a ratio of 1:2–1:4 of these components might prove efficacious in bone healing and repair. − PU, acting mechanically as a substitute for the organic constituents in natural bone, is a biocompatible polymer which provides the structure and flexibility to the scaffold. Incorporation of the inorganic, mineral components, nHA and DBPs (nHA+DBPs), into this polymeric matrix generates an environment compatible for integration with natural bone.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold

Bow

Newby

Rifkin

et al. 2019

ACS Appl. Bio Mater.

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The complex dynamic nature of bone tissue presents a unique challenge for developing optimal biomaterials within the field of bone tissue engineering. Materials based on biological and physiological characteristics of natural bone have shown promise for inducing and promoting effective bone repair. Design of multicomposite scaffolds that incorporate both malleable and hard mineral components allows for intricate structures with nano- and macrosized mineral components to provide architectural elements that promote osteogenesis. The examined S-1 and S-2 scaffolds are multilayered constructs which differ only in the compositional ratio of nanohydroxyapatite (nHA) and decellularized bone particles (DBPs). The constructs incorporated previously studied nHA/polyurethane films interspersed with macrosized bone DBPs to stimulate integration with native tissue and induce osteogenic activity. In vitro assessment of cytocompatibility and osteostimulatory characteristics indicated that the scaffolds did not negatively impact cell health and demonstrated osteogenic effects. When the constructs were implanted in vivo, in a rat tibial defect model, the biocompatibility and osteogenic impact were confirmed. Material-treated defects were observed to not induce negative tissue reactions and, in those treated with S-1 scaffolds, exhibited greater levels of new bone formation. These results indicate that, while both scaffold designs were biocompatible, S-1 constructs demonstrate more effective biologically relevant nano-/macromineral architectural elements.

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Section: Introductionmentioning

confidence: 99%

Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold

Bow

Newby

Rifkin

et al. 2019

ACS Appl. Bio Mater.

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show abstract

“…10 The majority of the mineral content of bone is in the form of calcium hydroxyapatite. The organic component of bone is composed largely of type I collagen.…”

Section: Tinubu and Scaleamentioning

confidence: 99%