Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review

Kuttappan, Shruthy; Mathew, Dennis; Nair, Manitha B.

doi:10.1016/j.ijbiomac.2016.06.043

Cited by 173 publications

(101 citation statements)

References 114 publications

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“…Today, biomaterials that are used to prepare scaffolds can be natural or synthetic, degradable or non-degradable. For example, natural polymers chitin and chitosan or collagen are being used for applications in tissue engineering [77,78]. Synthetic polymers such as Polycaprolactone (PCL), Poly-lactic acid (PLA) or Poly (lactic-co-glycolic) acid (PLGA) are biodegradable and can be produced with different features for applications in bone tissue engineering [79].…”

Section: Scaffolds-based Tissue Engineeringmentioning

confidence: 99%

Scaffolds and coatings for bone regeneration

Pereira

Cengiz

Silva

et al. 2020

J Mater Sci: Mater Med

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Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<6 mm) and clinical intervention is needed for critical-size defects and beyond that along with non-union bone fractures and bone defects larger than critical size represent a major healthcare problem. Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support. Bone tissue engineering strategies have been proposed to overcome the limited supply of grafts. Complete and successful bone regeneration can be influenced by several factors namely: the age of the patient, health, gender and is expected that the ideal scaffold for bone regeneration combines factors such as bioactivity and osteoinductivity. The commercially available products have as their main function the replacement of bone. Moreover, scaffolds still present limitations including poor osteointegration and limited vascularization. The introduction of pores in scaffolds are being used to promote the osteointegration as it allows cell and vessel infiltration. Moreover, combinations with growth factors or coatings have been explored as they can improve the osteoconductive and osteoinductive properties of the scaffold. This review focuses on the bone defects treatments and on the research of scaffolds for bone regeneration. Moreover, it summarizes the latest progress in the development of coatings used in bone tissue engineering. Despite the interesting advances which include the development of hybrid scaffolds, there are still important challenges that need to be addressed in order to fasten translation of scaffolds into the clinical scenario. Finally, we must reflect on the main challenges for bone tissue regeneration. There is a need to achieve a proper mechanical properties to bear the load of movements; have a scaffolds with a structure that fit the bone anatomy. Graphical Abstract* Helena Filipa Pereira

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Section: Scaffolds-based Tissue Engineeringmentioning

confidence: 99%

Scaffolds and coatings for bone regeneration

Pereira

Cengiz

Silva

et al. 2020

J Mater Sci: Mater Med

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“…Collagen, which is the most abundant protein in mammals, is widely used in biomedical applications and may also be appropriate for IVD regeneration [34,35]. In the extraction of collagen from skin tissue, pepsin is added to remove N-and C-terminal telopeptide components from collagen and to solubilize the collagen derivative [36]. This low-immunogenic derivative of collagen is called atelocollagen.…”

Section: Scaffolds and Appropriate Source Materialsmentioning

confidence: 99%

Intervertebral disc tissue engineering: A brief review

Stergar

Gradišnik

Velnar

et al. 2019

Bosn J of Basic Med Sci

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Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient’s quality of life. Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. The pathophysiology of IVD disease is still not well understood. Current therapies for IDD include conservative and invasive approaches, but none of those treatments are able to restore the disc structure and function. Recently, tissue engineering techniques emerged as a possible approach to treat IDD, by replacing a damaged IVD with scaffolds and appropriate cells. Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered the development of tissue engineering therapies. In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed.

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“…[1][2][3][4] Materials resembling the natural bone, like collagen and calcium phosphate ceramics, display inductive effects in stimulating bone repairing. [5][6][7][8] Well-known scaffolding materials like lactide-based aliphatic polyesters, however, lack such bioactive features. Bioactive components including bioceramics, [9,10] growth factors, [11,12] and drug molecules [13][14][15] are usually introduced into scaffolds to cover the shortage.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism Study on Effect of Biodegradable Amino Acid Ester–Substituted Polyphosphazenes in Stimulating Osteogenic Differentiation

Huang

Yang

et al. 2019

Macromolecular Bioscience

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Amino acid ester substituted polyphosphazenes are osteoactive benefiting from their phosphorus‐containing chemical structure, which highlights interests in bone tissue engineering. To correlate their chemical structures with cell activities, in this study, poly[(ethyl alanato)0.3(ethyl glycinato)0.7phosphazene] (PAGP) and poly[(ethyl phenylalanato)0.3(ethyl glycinato)0.7phosphazene] (PPGP) are synthesized to carry out studies on cell osteogenic differentiation. In the non‐contact culture manner, bone mesenchymal stromal cells (BMSCs) are cultured in transwell chambers containing PAGP or PPGP films, while the cells and the materials do not contact. In the contact culture manner, BMSCs are cultured on the PAGP or PPGP films. In the meantime, solutions containing PAGP or PPGP degradation products (i.e., phosphate, ammonium, and corresponding amino acids) are applied for cell culture using inorganic phosphate (Pi) ion as control. Thus, the influences from substrate surface and degradation products can be identified separately. The results reveal that both the phosphorus‐containing surface of PAGP and PPGP films and their degradation products play significant roles in regulating cell behaviors. In comparison with PAGP, PPGP seems able to provide relatively stable phosphorus‐containing surface to strengthen the cell‐scaffold interaction because of its slower degradation rate and higher Young's modulus, leading to greater promotion in osteogenic differentiation via contact effect.

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Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review

Cited by 173 publications

References 114 publications

Scaffolds and coatings for bone regeneration

Scaffolds and coatings for bone regeneration

Intervertebral disc tissue engineering: A brief review

Molecular Mechanism Study on Effect of Biodegradable Amino Acid Ester–Substituted Polyphosphazenes in Stimulating Osteogenic Differentiation

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