Effectiveness comparisons of Chinese patent medicine on sciatica

Abstract

Background: Sciatica is one of the common clinical diseases. Studies have proved the efficacy of Chinese patent medicine (CPM) in the treatment of sciatica, so far, there has not been a complete systematic review of its effectiveness and safety, and the comparative efficacy and safety of CPM have not been ranked. Therefore, it is necessary to evaluate the efficacy and safety of these CPM by means of systematic review and network meta-analysis (NMA), and to compare them in order. Methods: We will search PubMed, Cochrane Library, EMbase, Web of Science, CNKI, Wanfang, VIP, CBM and other databases for RCTs of CPM in the treatment of sciatica, (database established until December 30, 2020). In addition, we will manually search the “Pharmaceutical Information”, “National Essential Drug List”, “Chinese Pharmacopoeia”, etc. to inquire about drug instructions, and screen the market circulation and clinically commonly used CPM. We will use RevMan software, gemtc package, GeMTC software for statistical analysis, and draw the surface under cumulative ranking area (SUCRA) to predict the order of curative effect of treatment measures. Results: Our study will compare and evaluate the effectiveness of CPM in the treatment of sciatica, and rank different CPM. The outcome indicators will include clinical efficacy, pain degree, lumbar spine function and adverse events. Conclusion: Our research will provide support for clinical practice. INPLASY registration number: INPLASY2020110073.

Chinese patent medicine for functional dyspepsia effects

“…It is a commercialized preparation approved by the China Food and Drug Administration. [15,16] Since an increasing number of Chinese patent medicines in treating FD appeared, making clinical application a difficult decision as it remains inconclusive which Chinese patent medicine can obtain the greatest benefits. Therefore, we decide to rank the efficacy of these 9 Chinese patent medicines by network meta-analysis.…”

“…Chinese patent medicine as a type of TCM product uses herbal medicine as raw material and is processed into certain dosage forms according to the prescribed prescription. It is a commercialized preparation approved by the China Food and Drug Administration [15,16] . Since an increasing number of Chinese patent medicines in treating FD appeared, making clinical application a difficult decision as it remains inconclusive which Chinese patent medicine can obtain the greatest benefits.…”