Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children

Rocha, Érika Dantas de Medeiros; Brito, Naira Josele Neves de; Dantas, Márcia Marília Gomes; Silva, Alfredo de Araújo; Almeida, Maria das Graças; Brandão-Neto, José

doi:10.1080/07315724.2014.929511

Cited by 37 publications

(14 citation statements)

References 34 publications

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“…During the experimental period, participants in the Zn group were given 10 mg of zinc daily. Zinc concentration was determined based on previous studies [ 21 22 ]. After 6 months, the effects on weight, height, WAZ, HAZ, serum zinc, and IGF1 levels in participants were studied.…”

Section: Discussionmentioning

confidence: 99%

“…GH/IGF1 signal pathway is essential for growth in infants and children [ 31 ]. There have been many studies that associate zinc with IGF1 levels [ 32 21 33 ]. Zinc deficiency significantly reduced serum IGF1 concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the decrease in serum IGF1 concentrations was associated with decreased IGF1 gene expression in the liver of rats with zinc deficiency [ 32 ]. Oral administration of zinc (10 mg) for 3 months increased consumption of macronutrients and plasma IGF1 levels in children aged 8–9 years [ 21 ]. Cossack [ 33 ] reported that poor zinc status has been associated with low circulating IGF1 levels despite adequate caloric intake in humans.…”

Section: Discussionmentioning

confidence: 99%

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Effects of zinc supplementation on catch-up growth in children with failure to thrive

et al. 2017

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BACKGROUND/OBJECTIVESAlthough globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT.SUBJECTS/METHODSIn this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed.RESULTSZinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT.CONCLUSIONThese findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of zinc supplementation on catch-up growth in children with failure to thrive

et al. 2017

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“…Sirt 1 has been shown to deacetylate with the actions on other anti-aging genes. Zinc is the activator of Sirt 1 function with LPS closely connected to zinc deficiency with zinc supplementation essential to reduce LPS toxicity [38] [39]. Sirt 1's effects on cellular cholesterol homeostasis is by its deacetylase activity and ubiquitination of liver X receptor (LXR) proteins with the regulation of ATP-binding cassette transporter (ABCA1) and sterol regulatory element-binding protein 1cinvolved in cell cholesterol homeostasis [78] [79].…”

Section: Foxo3amentioning

confidence: 99%

“…Zinc deficiency and chronic disease has become important with zinc levels relevant to hormone bioactivity [3], Sirt 1 activity [28] and IGF-1 functions [37] [38]. Zinc supplementationhas become important to LPS toxicity with relevance to inflammation in various global populations [39] [40].…”

Section: Introductionmentioning

confidence: 99%

Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations

Martins¹

2016

AAR

120

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Appetite regulation by nutritional intervention is required early in life that involves the anti-aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes involved in cell circadian rhythm, senescence and apoptosis. Interests in anti-aging therapy with appetite regulation improve an individual's survival to metabolic disease induced by gene-environment interactions by maintenance of the anti-aging genes connected to the metabolism of bacterial lipopolysaccharides, drugs and xenobiotics. Interventions to the aging process involve early calorie restriction with appetite regulation connected to appropriate genetic mechanisms that involve mitochondrial biogenesis and DNA repair in neurons. In the aging process as the anti-aging genes are suppressed as a result of transcriptional dysregulation chronic disease accelerations and connected to insulin resistance, non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Interests in the gene-environment interaction indicate that the anti-aging gene Sirt 1that regulates food intake has been repressed early in the aging process in various global populations. The connections between Sirt 1 and other anti-aging genes such as Klotho, p66Shc (longevity protein) and Forkhead box proteins (FOXO1/ FOXO3a) have been associated with programmed cell death and alterations in these anti-aging genesregulate glucose, lipid and amyloid beta metabolism that are important to various chronic diseases.

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Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

et al. 2022

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Microelements represent an emerging resource for medicine and its preventive branch. Zinc is the second most abundant element in our organism with peculiar physiologic functions and pathophysiologic implications in systemic and gastrointestinal (GI) diseases. It interacts very often with gut microbiota (GM) and can affect natural course of GI diseases through a bidirectional relationship with intestinal bugs. We aimed to review literature data regarding zinc chemistry, role in health, and GI diseases in man with a special focus on its interaction with GM. We conducted a search on the main medical databases for original articles, reviews, meta‐analyses, randomized clinical trials and case series using the following keywords and acronyms and their associations: zinc, microelements, gut microbiota, gut health, and COVID‐19. Zinc has a rapid and simple metabolism and limited storage within our body. Its efficacy on immune system modulation reflects on improved response to pathogens, reduced inflammatory response, and improved atopic/allergic reactions. Zinc is also involved in cell cycle regulation (namely, apoptosis) with potential anti‐cancerogenic effects. All these effects are in a “symbiotic” relationship with GM. Finally, zinc shows preliminary viral antireplicative effects. Zinc seems to gain more and more evidences on its efficacy in allergic, atopic and infectious diseases treatment, and prevention. COVID‐19 can be the booster for research on future applications of zinc as perfect “postbiotic” in medicine.

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Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children

Abstract: Zinc supplementation stimulated an increase in the consumption of some macronutrients and basal serum zinc and improved plasma alkaline phosphatase levels. Zinc administration increased hormones of the GH-IGF1 system.

Cited by 37 publications

References 34 publications

Effects of zinc supplementation on catch-up growth in children with failure to thrive

Effects of zinc supplementation on catch-up growth in children with failure to thrive

Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations

Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

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