Anti-Aging Genes Improve Appetite  Regulation and Reverse Cell Senescence  and Apoptosis in Global Populations

Martins, Ian James

doi:10.4236/aar.2016.51002

Cited by 95 publications

(59 citation statements)

References 123 publications

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“…Age dependent behavioural abnormalities such as: impaired rotarod performance, abnormal leg-clasping reflex, and hyperactivity were observed in NRF1 deficient mice. Moreover, corresponding brain atrophy due to apoptosis in NRF1 deficient mice was observed [110][111][112]. Mutation in APOE4 that blocks NRF1 binding to the exon 4 of the gene has been recently linked to AD [113].…”

Section: Nuclear Respiratory Factor and Related Psychological Abnormamentioning

confidence: 99%

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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Structural changes in different regions of the brain have become clinically relevant and regarded as the signature phenomenon for neurological diseases. Morphological changes in brain are also associated with neuronal and neurochemical alterations. Studies have showed that minute changes in neurochemical levels may have marked impact on the psychobehaviour of the subject. Several neurological disease profiles have been reported with such specific psychobehavioural expression. However, application of behavioural abnormalities as possible disease progress markers has not been considered and emphasised much. Reports suggested that-the subjects, who have already entered into the terminal stage of the disease, used to show cardinal behavioural signs for a specific disease profile. However, psychological expressions are comparatively early expressive. As most of the neurodegenerative disorders are unidirectional and progressive by nature, therapeutic intervention at the right time is essential for attaining the desired outcome. Moreover, early diagnosis can aid in managing the disease progression also. Psychobehavioural analysis could meet the expected outcome of disease diagnosis if implemented properly and timely. In the present review, we have amalgamated the reported behavioural anomalies with the supportive background from neurochemical basis. Further, we have concluded that behaviour centric studies could be a potential diagnostic tool for the early diagnosis of major neurological diseases such as Alzheimer disease, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), Bipolar disorder, Schizophrenia, Impulse control disorder (ICD) and Obsessive-compulsive disorder (OCD).

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Section: Nuclear Respiratory Factor and Related Psychological Abnormamentioning

confidence: 99%

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury¹,

Sahu²,

Ramanujam³

et al. 2018

Neuropsychiatry

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“…Sirt 1 is involved in telomere maintenance and DNA repair with its critical involvement chromosome stability and cell proliferation. Sirt 1 is important to the regulation of other anti-aging genes such as klotho, p66shc and Forkhead box protein O1 with relevance to age related diseases (8).…”

Section: Editorialmentioning

confidence: 99%

Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals

2018

IJOAR

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The process of aging is determined by various genetic and environmental factors. Aging is associated with increased oxidative stress that alters cellular chromatin structure, DNA methylation with histone modifications. These epigenetic alterations lead to nuclear changes associated with mitochondrial apoptosis that is a major defect in the global chronic disease epidemic (1). The variability in longevity between individuals in different communities implicate various nutritional and environmental factors involved in transcriptional dysregulation that lead to cell damage that accumulates with age and contributes to mitophagy, insulin resistance and programmed cell death. The absence or malfunction of a gene (2) necessary for transcriptional regulation of gene expression, DNA repair and telomere maintenance in neurons has become essential with relevance to neurodegeneration that determines aging and lifespan.

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“…Diet that are high in fat promote LPS absorption [4] and high fat diet have been also associated with magnesium deficiency. Sirt1 inhibitors such as alcohol, palmitic acid and butyric acid [24] (Figure 3) should be avoided with low palmitic acid diets essential for prevention of NAFLD and for rapid liver metabolism of glucose, cholesterol and amyloid beta. Stress and the neuroendocrine system are closely involved in appetite regulation with the corruption of the apelinergic pathway [114] associated with kidney disease (magnesium deficiency), NAFLD and reduced Aβ oligomer metabolism [114].…”

Section: Unhealthy Diets Exercise and Stress Prevent Magnesium Theramentioning

confidence: 99%

“…Reversal of cell senescence involves magnesium and Sirt1 interactions that improve appetite dysregulation connected to autonomous disease and Type 3 diabetes in a population by activation of other anti-aging genes that may delay the rate of chronic diseases [24] [25] (Figure 1). Autonomous disease that involves magnesium and Sirt1 dysregulation may be relevant to defective calcium ion channel activity and linked to emergency acute myocardial infarction and ischemic heart disease [26]- [28] and may not be relevant to levels of CK-MB and statin use [29]- [32].…”

Section: Introductionmentioning

confidence: 99%

“…anti-aging genes [24] [25] may be involved with magnesium therapy and the regulation of mitochondrial apoptosis in various cells and tissues [25]. Appetite dysregulation and Type 3 diabetes have been linked to higher brain dysregulations (higher cerebral cortex areas) that corrupt the hypothalamus, sympathetic and non-sympathetic nervous system with close connections between magnesium and Sirt1 in the regulation of the circadian rhythm [4] [33], stroke [34]- [37], NAFLD [38]- [40] diabetes [41]- [47] and neurodegenerative diseases [48]- [52].…”

Section: Introductionmentioning

confidence: 99%

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Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

Martins¹

2016

Health

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In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer's disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions with the prevention of myocardial infarction and Type 3 diabetes. Magnesium deficiency and its effects on Sirt1 regulation have become important with magnesium deficiency associated with appetite dysregulation, senescence, glucose/nitric oxide dyshomeostasis, increased ceramide and toxic amyloid beta formation. Magnesium therapy activates the peripheral sink amyloid beta clearance pathway with the reversal of cell senescence associated with various chronic diseases such as cardiovascular disease, Type 3 diabetes and Alzheimer's disease.

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Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations

Cited by 95 publications

References 123 publications

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals

Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

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