Effect of Zicao ointment on second-degree burns in rats

Luo, Hong-Bin; Cao, Yu; Tao, Mao-can; Yang, Xiaohong; Wang, Youli

doi:10.4314/tjpr.v16i4.18

Trop. J. Pharm Res

2017

DOI: 10.4314/tjpr.v16i4.18

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Effect of Zicao ointment on second-degree burns in rats

Hong-Bin Luo¹,

Yu Cao²,

Mao-can Tao³

et al.

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Cited by 3 publications

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“…4,6,7 GO can significantly promote wound healing without obvious adverse reactions in burned or scalded patients. 8,9 Gromwell has many beneficial effects. GO forms a protective localized lipid film and increases local tissue resistance.…”

mentioning

confidence: 99%

Effectiveness of gromwell ( Lithospermum erythrorhizon ) oil in the treatment of toxic epidermal necrolysis in a patient with dermatomyositis

Liang

Wang

2020

Dermatologic Therapy

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Toxic epidermal necrolysis (TEN), a delayed-type hypersensitivity reaction, is the most severe form of severe cutaneous adverse reactions. 1 Patients with TEN often have skin infections covering large areas of exposed skin. Although causative drug withdrawal and supportive care can halt disease progression, how to promote the early recovery of skin lesions is still a challenge in clinical care. Gromwell (Lithospermum erythrorhizon), known as zicao in China, is used for the F I G U R E 1 A, Rash, myalgia, extensive fissures and hardened membrane in admission; B, exposure therapy and using gromwell oil soak sterile gauze covered the whole body; C, 40 days after treatment; D, discharge day

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mentioning

confidence: 99%

Effectiveness of gromwell ( Lithospermum erythrorhizon ) oil in the treatment of toxic epidermal necrolysis in a patient with dermatomyositis

Liang

Wang

2020

Dermatologic Therapy

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Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

et al. 2022

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Wound healing in second-degree burns in rats treated with silver sulfadiazine: a systematic review and meta-analysis

2022

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Objective: This study aims to assess the wound healing efficacy in second-degree burns in rats treated with 1% silver sulfadiazine (SSD)—a sulfonamide antibiotic. Method: This is a systematic literature review and meta-analysis performed according to the PICO (Population, Intervention, Comparison and Outcomes) strategy. Results: The review found 100 studies in PubMed, Web of Science and other search engines. Of these, 70 studies were pre-selected after removing duplicates. After independent analysis by two reviewers, only seven studies met the inclusion criteria for meta-analysis. All studies except one showed faster wound closure by the application of silver sulfadiazine ointment. Using a random effects model, healing was faster in SSD-treated groups when compared to the control group on day 21, with a statistically significant mean difference of –2.72 days (95% confidence interval: –4.99, –0.45) between treatment and control groups (p<0.01). Conclusion: The results of this meta-analysis revealed that SSD aided in faster healing of second-degree burns.

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Effect of Zicao ointment on second-degree burns in rats

Cited by 3 publications

References 8 publications

Effectiveness of gromwell ( Lithospermum erythrorhizon ) oil in the treatment of toxic epidermal necrolysis in a patient with dermatomyositis

Effectiveness of gromwell ( Lithospermum erythrorhizon ) oil in the treatment of toxic epidermal necrolysis in a patient with dermatomyositis

Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches

Wound healing in second-degree burns in rats treated with silver sulfadiazine: a systematic review and meta-analysis

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