Wound healing in second-degree burns in rats treated with silver sulfadiazine: a systematic review and meta-analysis

Devi, Mohan Vimala; Poornima, V.; Uma, T.

doi:10.12968/jowc.2022.31.sup4.s31

Cited by 6 publications

(3 citation statements)

References 65 publications

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“…Herein, the effect of our composite (sesame oil 30%, olive oil 10%, rosemary oil 10% and chamomile oil 10%, clover flower bee honey 20% and Vaseline base 20%) on the skin regeneration process was compared with the most famous commercially available creams used in the treatment of skin burns in Egypt, MEBO ® and DERMAZIN ® . MEBO ® is composed mainly of 0.25% β-sitosterol in a base of sesame oil and beeswax [ 53 ], while DERMAZIN ® is composed of 1% silver sulfadiazine, which was used previously in many studies on the matter of burn healing process [ 54 , 55 , 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Anis

Sharshar

Hanbally

et al. 2022

JCM

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Skin burns are one of the most difficult medical problems. Recently, studies have been directed towards development of natural products in order to identify effective and safe remedies. In the present study, we evaluated the efficacy of a natural composite (formulated from honey and essential oils) compared with MEBO® (0.25% β-sitosterol) and DERMAZIN® creams (1% silver-sulfadiazine) in the treatment of thermally induced skin burns. For this purpose, four burn-wounds were created on the back of male New Zealand rabbits (n = 10) using a thermal stamp under the effect of general anesthesia. Each wound represents one of the following groups: non-treated, natural composite-cream, MEBO®-cream, and silver-sulfadiazine treated groups, respectively. Treatments were applied once a day topically until one of these wounds appeared to be healed grossly. The non-treated group received no treatment. Grossly, skin burns have been healed after 28 days of the treatment in all groups except of the non-treated group. The healing efficacy of the natural composite, MEBO® and silver-sulfadiazine creams was quite similar macroscopically. However, microscopically, the epidermal layer of the composite-cream treated group was more mature than those of both MEBO® and silver-sulfadiazine creams treated groups. In conclusion, the tested composite may be a promising effective and inexpensive treatment of skin burns.

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Section: Discussionmentioning

confidence: 99%

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Anis

Sharshar

Hanbally

et al. 2022

JCM

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“…Moreover, SSD has been demonstrated to be effective also against multidrug-resistant organisms [ 21 , 22 ]. The development of active dressings able to control SSD release over time is of great interest for applications in wound healing, as demonstrated by the several publications reported on this topic [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. By considering about 70 published papers on the use of SSD in wound healing, an interesting review demonstrated, through a random effects model, that healing goes faster (−2.72 days; 95% confidence interval: −4.99, −0.45) in SSD-treated groups when compared to the control group over 21 days [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Chitosan/Alginate Hydrogels for the Controlled Release of Silver Sulfadiazine in Wound Healing Applications: Design, Characterization and Antimicrobial Activity

et al. 2023

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The growing demand for personalized medicine requires innovation in drug manufacturing to combine versatility with automation. Here, three-dimensional (3D) printing was explored for the production of chitosan (CH)/alginate (ALG)-based hydrogels intended as active dressings for wound healing. ALG hydrogels were loaded with 0.75% w/v silver sulfadiazine (SSD), selected as a drug model commonly used for the therapeutic treatment of infected burn wounds, and four different 3D CH/ALG architectures were designed to modulate the release of this active compound. CH/ALG constructs were characterized by their water content, elasticity and porosity. ALG hydrogels (Young’s modulus 0.582 ± 0.019 Mpa) were statistically different in terms of elasticity compared to CH (Young’s modulus 0.365 ± 0.015 Mpa) but very similar in terms of swelling properties (water content in ALG: 93.18 ± 0.88% and in CH: 92.76 ± 1.17%). In vitro SSD release tests were performed by using vertical diffusion Franz cells, and statistically significant different behaviors in terms of the amount and kinetics of drugs released were observed as a function of the construct. Moreover, strong antimicrobial potency (100% of growth inhibition) against Staphylococcus aureus and Pseudomonas aeruginosa was demonstrated depending on the type of construct, offering a proof of concept that 3D printing techniques could be efficiently applied to the production of hydrogels for controlled drug delivery.

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“…Normal skin regeneration is imperative for maintaining hemostasis in healthy individuals and patients with diabetes [2]. Wounds have been treated for decades using topically applied silver sulfadiazine, pentoxifylline, and psoralen, which may harm the skin [3]. These agents have side effects, such as allergic reactions, hyperosmolality, silver staining of the burn wound, and hemolysis [4]; therefore, there is a need to use a new technique that can overcome all these drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly Synthesis of Silver Nanoparticles by Nitrosalsola vermiculata to Promote Skin Wound Healing

et al. 2023

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Eco-friendly synthesis of silver nanoparticles (SN) by using a naturally occurring plant, such as Nitrosalsola (Salsola) vermiculata (SV), could be a novel way for appropriate wound healing. AgNO3 was reduced by SV to produce safe SN (SN-SV) extract and hasten the wound healing process. The obtained SN-SV were characterized by size, charge, wavelength, and surface morphology. The optimized formulation was dispersed in O/W cosmetic cream. Then, it was characterized in terms of pH, viscosity, homogeneity, and permeability. The ex vivo and in vivo studies have been conducted in a rat animal model to assess the potential of SN-SV cream on skin tissue regeneration. A skin punch biopsy was obtained to investigate the histopathological (HP) changes in the skin lesions of all rats by the H&E staining and PCNA immunostaining methods. The skin wounds in all subgroups were examined on days 5, 11, and 15 to analyze the effectiveness of SN-SV cream for treating surgical skin wounds. The prepared SN-SV had a particle size of 37.32 ± 1.686 nm, a charge of −1.4 ± 0.7 mV, non-aggregated SN-SV, and a λmax of 396.46 nm. The formed SN-SV cream showed a pH near the skin’s pH, with suitable viscosity and homogeneity and an apparent permeability of 0.009 ± 0.001. The HP changes in the SN-SV subgroups revealed a substantial reduction in wound size and improvement in wound granulation tissue formation and epidermal re-epithelialization (proliferation) compared to the healing in the SN subgroups. The current work revealed that SN-SV could be a novel skin-wound-healing agent with a practical application as a wound-healing platform.

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Wound healing in second-degree burns in rats treated with silver sulfadiazine: a systematic review and meta-analysis

Cited by 6 publications

References 65 publications

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

3D Printed Chitosan/Alginate Hydrogels for the Controlled Release of Silver Sulfadiazine in Wound Healing Applications: Design, Characterization and Antimicrobial Activity

Eco-Friendly Synthesis of Silver Nanoparticles by Nitrosalsola vermiculata to Promote Skin Wound Healing

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