The synthesis and characterization of a novel inorganic glass composite membrane consisting of a
mixture of phosphotungstic acid and phosphomolybdic acid are reported. Phosphosilicate gels doped
with these two proton conducting donor components were derived by a sol−gel method. The influence
of the textural properties of the glass composites could be interpreted from N2 adsoption−desorption
isotherms. The pore size was less than 6 nm for all glass membranes. These glass membranes were
found to be stable up to 400 °C. Fourier transform infrared spectroscopy indicated that the characteristic
Keggin anions PW12O40
3- and PMo12O40
3- were present in the glass composite membrane. The highest
proton conductivity was measured to 1.01 × 10-1 S cm-1 at 85 °C with 85% relative humidity (RH).
Membrane electrode assemblies were prepared and showed good performance, with a maximum power
density value of 35 mW/cm2 at 93 mA/cm2 as well as a current density of 137 mA/cm2 when utilized in
a H2/O2 fuel cell at 28 °C and 30% RH.
The present study is designed to assess the potential benefits of controlled delivery of silver sulfadiazine from collagen scaffold (SSDM-CS) in infected deep partial thickness burn wounds in which epidermis is lost completely and the entire papillary dermis and most of the recticular layer of the dermis is lost. Infection induced by inoculating 10(7) colony forming units (cfu) of Pseudomonas aeruginosa caused significant increase in wound size (20%) till day 15, which decreased significantly from day 9 by SSDM-CS treatment, showing complete healing by day 27 (control > or = 37 days). Early subsidence of infection (<10(2) cfu, day 9) by SSDM-CS resulted in faster epidermal resurfacing and fibroplasia, whereas heavy microbial load (>10(7) cfu, day 9) in controls caused severe inflammatory cellular infiltration. Persistent infection triggered early expression of proinflammatory cytokines intereukin-6, intereukin 1-beta, and tumor necrosis factor-alpha, lasting until day 9, whereas cytokine level decreased in SSDM-CS-treated group by day 6. Infection exacerbated expression of active matrix metalloproteinases (MMPs)-2 and -9 in controls (day 15), while SSDM-CS positively modulated MMP-2 and -9 with faster decline in their levels (day 12). Inherent nature of the dressing to maintain drug level at equilibrium therapeutic concentration (51.2 microg/mL) for prolonged time (72 h), below systemic toxic limits (20 microg/dL, serum level), accelerated the magnitude and sequence of reparative events.
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