Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment

Uehara, Kazuaki; Tagami, Tatsuaki; Miyazaki, Itaru; Murata, Norikazu; Takahashi, Yoshifumi; Ohkubo, Hiroshi; Ozeki, Tetsuya

doi:10.3109/03639045.2014.917093

Cited by 8 publications

(3 citation statements)

References 26 publications

(20 reference statements)

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“…X-ray irradiation doses were selected based on the doses used in X-ray machines for security purposes (0.12 mGy from one pass) [1]. Doses were determined from the reference dose for the investigation of X-ray effects on pharmaceuticals.…”

Section: Methodsmentioning

confidence: 99%

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Esr Investigation of X-Ray Exposure on Some Anti-Diabetics and Proton Pump Inhibitors

Sarcan¹,

Tas²,

Silindir-Gunay³

et al. 2020

RAP 2019 Conference Proceedings

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X-ray is ionizing radiation used in several areas such as analytical sciences, medicine and security areas. X-ray machines are used in the entrance of important places (airports, shopping centers, etc.) for security purposes. The aim of this study was the investigation of the potential effects of X-ray irradiation on anti-diabetics (metformin HCl, pioglitazone HCl) and proton pump inhibitors (PPI) (lansoprazole, pantoprazole sesquihydrate) pharmaceuticals which are used in chronic diseases by Electron Spin Resonance (ESR). ESR analysis was done before and after different X-ray irradiation doses. Afterwards, ESR spectra and resonance peaks were evaluated. As a result, no significant free radicals were detected by ESR resonance peaks and also, their ESR intensities did not change significantly by increasing X-ray doses.

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Section: Methodsmentioning

confidence: 99%

“…X-ray irradiation having short wavelength and high penetration capability is used in several areas nowadays. Especially, it is used for security in several control points such as passenger bags screening at airports, shopping centers, etc., with evolving technologies [1].…”

Section: Introductionmentioning

confidence: 99%

Esr Investigation of X-Ray Exposure on Some Anti-Diabetics and Proton Pump Inhibitors

Sarcan¹,

Tas²,

Silindir-Gunay³

et al. 2020

RAP 2019 Conference Proceedings

View full text Add to dashboard Cite

show abstract

“…The impact of X-ray radiation on small molecules has been reported. 101 The X-ray doses used in this study included 0.34 mGy (corresponding to thrice the dose from typical scanning in X-ray inspection equipment), 0.1 Gy (the limit specified by the food sanitation law in Japan), 0.5 Gy (a dose that has severe effects on blood cells) and 300 Gy (the maximum dose from our X-ray equipment).…”

Section: Transportation and Handling Of Primary Packagingmentioning

confidence: 99%

Stress Factors in Primary Packaging, Transportation and Handling of Protein Drug Products and Their Impact on Product Quality

Narhi

Chou

Christian

et al. 2022

Journal of Pharmaceutical Sciences

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Ionizing radiation and its effects on pharmaceuticals

Sarcan

Özer

2019

J Radioanal Nucl Chem

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Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment

Abstract: The X-ray scanning and X-ray exposure under our experimental conditions did not affect the pharmaceutical quality of drug tablets.

Cited by 8 publications

References 26 publications

Esr Investigation of X-Ray Exposure on Some Anti-Diabetics and Proton Pump Inhibitors

Esr Investigation of X-Ray Exposure on Some Anti-Diabetics and Proton Pump Inhibitors

Stress Factors in Primary Packaging, Transportation and Handling of Protein Drug Products and Their Impact on Product Quality

Ionizing radiation and its effects on pharmaceuticals

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