Ionizing radiation and its effects on pharmaceuticals

Sarcan, Elif Tugce; Özer, A. Yekta

doi:10.1007/s10967-019-06954-3

Cited by 10 publications

(5 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ionizing radiation technology is now very active and widely used in agriculture, medicine, and the environment [ 79 , 80 , 81 ]. The irradiation process is carried out at a normal temperature and the operation is simple and easy to control.…”

Section: Preparation Methods Of Smart Hydrogelsmentioning

confidence: 99%

Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

Materials with excellent biocompatibility and targeting can be widely used in the biomedical field. Hydrogels are an excellent biomedical material, which are similar to living tissue and cannot affect the metabolic process of living organisms. Moreover, the three-dimensional network structure of hydrogel is conducive to the storage and slow release of drugs. Compared to the traditional hydrogel preparation technologies, ionizing radiation technology has high efficiency, is green, and has environmental protection. This technology can easily adjust mechanical properties, swelling, and so on. This review provides a classification of hydrogels and different preparation methods and highlights the advantages of ionizing radiation technology in smart hydrogels used for biomedical applications.

show abstract

Section: Preparation Methods Of Smart Hydrogelsmentioning

confidence: 99%

Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Thus, liquid pharmaceuticals are often considered less stable than solid or powdered dosage forms, given the formation of radical oxygen species from the breakdown of water when it is irradiated ( Blue et al, 2019b ). Although pharmaceuticals in the solid state undergo almost no indirect ionization, they are not exempt from damage caused by direct radiation on individual molecules ( Ambroż et al, 2000 ; Sarcan and Ozer, 2020 ).…”

Section: The Current State Of Medicines In Spacementioning

confidence: 99%

To infinity and beyond: Strategies for fabricating medicines in outer space

Seoane-Viaño¹,

Ong²,

Basit³

et al. 2022

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

“…Sterilization methods are used to inactivate microorganisms. An official sterilization technique of drugs that is accepted by the IAEA and listed in pharmacopeias is radiation sterilization [ 21 ]. Sterilization is necessary for pharmaceutical items in order to assure their safety and efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…Sterilization is necessary for pharmaceutical items in order to assure their safety and efficacy. The effect of ionizing radiation on drugs has been extensively studied for more than 20 years [ 21 ]. A range of medications, including vitamins, antiprotozoals, antibiotics, steroids, and anticancers, have been researched in relation to pharmacological sterilization [ 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Do Rutin and Quercetin Retain Their Structure and Radical Scavenging Activity after Exposure to Radiation?

et al. 2023

View full text Add to dashboard Cite

The influence of ionizing radiation on the physicochemical properties of quercetin and rutin in the solid state was studied. Quercetin and rutin were irradiated with the standard recommended radiation dose (25 kGy) according to EN 522 standard. The samples were irradiated by electron beam radiation. EPR studies indicate the formation of a small number of free radicals due to irradiation. Moreover, some radicals recombined with the mean lifetime of 1200 and 93 h, and a stable radical concentration reached only 0.29 and 0.90 ppm for quercetin and rutin, respectively. The performed spectroscopic study (FT-IR) confirmed the radiostability of the flavonoids tested. Chromatographic tests (HPLC, HPLC-MS) showed that irradiation of quercetin and rutin with a 25 kGy dose did not change the physicochemical properties of the tested compounds. Degradation products were not observed. The antioxidant activities were determined by the 2,2-diphenyl-1-pycrylhydrazyl (DPPH) free radical scavenging activity assay, ABTS Radical Scavenging Assay (ABTS), Ferric Reducing Antioxidant Power Assay (FRAP), Cupric Ion Reducing Antioxidant Capacity Assay (CUPRAC). The conducted research confirmed that exposure to ionizing radiation does not change the chemical structure of tested flavonoids and their antioxidant properties.

show abstract

Ionizing radiation and its effects on pharmaceuticals

Cited by 10 publications

References 51 publications

Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

Recent Advances in Smart Hydrogels Prepared by Ionizing Radiation Technology for Biomedical Applications

To infinity and beyond: Strategies for fabricating medicines in outer space

Do Rutin and Quercetin Retain Their Structure and Radical Scavenging Activity after Exposure to Radiation?

Contact Info

Product

Resources

About