Effect of vitamin E and C supplementation combined with oral antidiabetic therapy on the endothelial dysfunction in the neonatally streptozotocin injected diabetic rat

Alper, Gülinnaz; Olukman, Murat; Irer, Seda; Çağlayan, Osman; Duman, Erdal; Yılmaz, Candeğer; Ülker, Sibel

doi:10.1002/dmrr.586

Cited by 28 publications

(18 citation statements)

References 46 publications

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“…These findings according with our study that inhibition effects of vit E on Oxidative stress produced in diabetes patients. Alper et al [28] showed that there is an imbalance in oxidant/antioxidant status in the type-2 diabetes model of rat and vitamin supplementation improves the impairment in diabetic vasculature.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Beyramzadeh¹,

Ansari²,

Azimzadeh³

et al. 2017

JPP

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Abstract:Objective: We aimed to investigate protective effects of vit E on oxidative stress status and homocysteine (Hcy) in cardiac tissue of diabetic rats. Methods: Sixteen Wistar male rats were treated with STZ (streptozotocin) (60 mg/kg) to induce diabetes. Diabetic rats were divided into two groups: NTD (non-treated diabetic) and V E TD (vit E-treated diabetic) rats. The V E TD group received 300 mg/kg vit E with daily feeding. Eight normal rats of the same age were used as the control group. After 6 weeks, the rats were anesthetized, their cardiac tissue was removed, and homogenated supernatant was separated. Samples were assayed for TAC (total antioxidant capacity), LPO (lipid peroxidation), nitrite (NO 2 -), nitrate (NO 3 -), and Hcy. Key Findings: The contents of LPO, NO 3 -and Hcy in NTD compared to control group indicate a significant increase, but the levels of these parameters decreased in V E TD (p < 0.05). There was a significant decrease in the amount of TAC in the NTD group but in V E TD group, that significantly increased (p < 0.05). The amount of NO 2 -in NTD and V E TD groups, compared to the control group, did not show any significant changes (p > 0.05).Conclusions: Significant decrease of oxidative stress and Hcy in the cardiac tissue caused by vit E supplementation strongly indicated that this radical scavenger may promote a protective effect on diabetic cardiomyopathy through the attenuation of oxidative stress and increase antioxidant defense mechanism.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Beyramzadeh¹,

Ansari²,

Azimzadeh³

et al. 2017

JPP

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“…40,41 However, some studies reported that antioxidant vitamin supplementation may lead to endothelium dysfunction in both diabetic and normal animals. 42,43 Proposed mechanisms for this observation include prooxidant effects of vitamin E on vitamin C in the presence of NO and/or de novo synthesis of vasoconstrictive prostanoids. 44 Differing levels of vitamin E and C prior to repletion may also play a role.…”

Section: Animal Studiesmentioning

confidence: 99%

Antioxidants, Diabetes, and Endothelial Dysfunction

Doupis¹,

Veves²

2007

US Endocrinology

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“…It is frequently co-administered with vitamin C because its oxidized form is regenerated by vitamin C. Vitamin E and C supplementation improves markers of oxidative stress and endothelium-dependent vasodilation in experimental diabetic models (42–45). Acute administration of vitamin E has generally been shown to improve endothelial dependent brachial artery vasodilatation in both type 1 and 2 diabetes (46).…”

Section: Therapeutic Interventions That Modify Oxidative Stressmentioning

confidence: 99%

Therapeutic interventions and oxidative stress in diabetes

Rahangdale

Yeh²,

Malhotra³

et al. 2009

Front Biosci

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Many therapeutic agents that are used in patients with diabetes mitigate oxidative stress. These agents are of particular interest because oxidative stress is elevated in diabetes and is thought to contribute to vascular dysfunction. Agents that merely quench already formed reactive oxygen species have demonstrated limited success in improving cardiovascular outcomes. Thus, although vitamin E, C, and alpha lipoic acid appeared promising in animal models and initial human studies, subsequent larger trials have failed to demonstrate improvement in cardiovascular outcomes. Drugs that limit the production of oxidative stress are more successful in improving vascular outcomes in patients with diabetes. Thus, although statins, ACE inhibitors, ARBs and thiazolinediones are used for varied clinical purposes, their increased efficacy in improving cardiovascular outcomes is likely related to their success in reducing the production of reactive oxygen species at an earlier part of the cascade, thereby more effectively decreasing the oxidative stress burden. In particular, statins and ACE inhibitors/ARBs appear the most successful at reducing oxidative stress and vascular disease and have potential for synergistic effects.

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Effect of vitamin E and C supplementation combined with oral antidiabetic therapy on the endothelial dysfunction in the neonatally streptozotocin injected diabetic rat

Cited by 28 publications

References 46 publications

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Antioxidants, Diabetes, and Endothelial Dysfunction

Therapeutic interventions and oxidative stress in diabetes

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