Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Beyramzadeh, Mojtaba; Ansari, Mohammad Hassan Khadem; Azimzadeh, Kaveh; Salami, Siamak

doi:10.17265/2328-2150/2017.010.002

Cited by 2 publications

(2 citation statements)

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“…The alteration of AOPP, NO and HCys levels may be due to altered oxidant/antioxidant balance which favored oxidants or the progression of the inflammatory process. Similar results were reported by Škvařilová et al 66 for AOPP, by Stadler et al 67 for NO and by Beyramzadeh et al 68 for HCys, respectively. We observed that all these parameters were nearly restored by metformin administration to the cancer, diabetic and DC rats.…”

Section: Discussionsupporting

confidence: 89%

Metformin protects against diabetes-induced heart injury and dunning prostate cancer model

et al. 2020

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In this study, both diabetes and Dunning prostate cancer were induced for the first time in Copenhagen rats in vivo. Thus, the effects of metformin against heart tissue damage of these rats were investigated by biochemical methods. Dunning prostate cancer was induced in Copenhagen rats using high metastatic MAT-LyLu cells. The rats were divided as follows: Control group: only injected with 0.9% NaCl for 14 days; Diabetic group: only injected single dose of streptozotocin (STZ) (65 mg/kg); Cancer group: subcutaneously (s.c) inoculated with 2 x 104 MAT-LyLu cells only; Diabetic + cancer (DC) group: inoculated with 2 x 104 MAT-LyLu cells and STZ injection, Cancer + metformin (CM) group: injected with metformin for 14 days after Mat-LyLu cells application; Diabetic + cancer + metformin (DCM) group: metformin administered for 14 days together with STZ and Mat-LyLu cells. At the end of the experimental period, heart tissues were taken. Reduced glutathione and total antioxidant status levels in heart tissues were decreased, whereas lipid peroxidation, advanced oxidized protein products, nitric oxide, homocysteine, and reactive oxygen species levels, total oxidant status and catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and xanthine oxidase activities increased in the diabetic, cancer and DC groups. Treatment with metformin reversed these effects. In conclusion, the present study shows that metformin has a protective effect against heart tissue damage in STZ-induced diabetic rats with Dunning prostate cancer.

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Section: Discussionsupporting

confidence: 89%

Metformin protects against diabetes-induced heart injury and dunning prostate cancer model

et al. 2020

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“…[3][4][5] Different studies showed that two factors, such as increased oxidative stress and decrease in antioxidant capacity, are playing an important role in the pathogenesis of chronic diabetes mellitus. [6][7][8] Streptozotocin (STZ) is a broad-spectrum antibiotic having cytotoxic activity that induces diabetes…”

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confidence: 99%

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Maiti¹

2017

IJGP

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Background: Tamarindus indica Linn. (Caesalpiniaceae) is a well-known traditional plant used by the tribes as well as rural sectors of tropical countries. Locally, it is named as Tantul and recognized as therapeutic uses of different diseases. Aim: The present study aimed to evaluate the efficacy of hydromethanolic extract of T. indica Linn. seed in streptozotocin (STZ)-induced diabetic testicular dysfunction correction. Materials and Methods: STZ-induced diabetic state has been established here by single intramuscular injection of STZ (6 mg/100 g body weight in citrate buffer, pH 4.5) resulted hyperglycemia. STZ-induced experimental diabetes resulted testicular dysfunctions evaluated by sperm count, sperm motility, viability, and seminal vesicle fructose content as well as by the level of serum testosterone. Testicular oxidative stress has been observed by the monitoring of catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase activities. Quantification of thiobarbituric acid reactive substances and conjugated diene in testicular tissue was assessed. General and metabolic toxicity assessment parameters were studied. Results: Administration of hydromethanolic extract to STZ-induced diabetic rat at the dose of 80 mg/100 g body weight/day for 28 days resulted a significant protection in fasting blood glucose, serum insulin, and serum testosterone levels (P < 0.05) along with the correction of testicular above-mentioned parameters as well as semen analysis parameters toward the control level (P < 0.05). This extract has no general toxic effect on the body weight, along with no metabolic toxicity that was reflected here by the assessment of serum glutamate oxaloacetate transaminase and pyruvate transaminase activities. Conclusion: These data demonstrated that T. indica significantly improved STZ-induced diabetic complication in rat testis. This study suggested that hydromethanolic extract might have a protective role against oxidative stress-induced impairment in testicular functions in diabetic rats.

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Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

Cited by 2 publications

References 30 publications

Metformin protects against diabetes-induced heart injury and dunning prostate cancer model

Metformin protects against diabetes-induced heart injury and dunning prostate cancer model

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