Antioxidants, Diabetes, and Endothelial Dysfunction

Doupis, John; Veves, Aristidis

doi:10.17925/use.2007.00.2.61

Cited by 4 publications

(5 citation statements)

References 64 publications

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“…It is the hyperglycemia in the DM causing TAC levels to decrease. This agrees with Doupis and Veves (2007) who found that antioxidant levels decrease in diabetic patients with increased oxidative stress and so it is decreased neutralization of oxidant levels that is causing the lipid peroxidation and causing the rise in MDA levels in the serum [20].…”

Section: Discussionsupporting

confidence: 91%

“…The survey conducted in Al Qassim, Saudi Arabia revealed that 12.4% were dependent on IADL and 7.9% were dependent on ADL [19]. Generally, the deficit in IADL precedes the deficit in ADL [20] and the rate of decline in IADL is faster than that of ADL [21,22]. This was explained by Béland and Zunzunegui (1995) [22] by the greater physical and cognitive integrity required for performing IADL.…”

Section: Discussionmentioning

confidence: 99%

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Rates and Determinants of Functional Limitations among the Elderly Population in Al-Dakhlyia Region , Sultanate of Oman

Al-Sabahi¹,

Sinawi²,

Al-Hinai³

2013

MEJAA

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Background: Ageing of the Omani society calls for the evaluation of functional abilities and the factors that should be addressed by health programs. This study was conducted to reveal the extent and determinants of dependency on IADL and ADL among the elderly in Al-Dakhliyah governorate, Oman.Methods: Records of the comprehensive assessment of elderly population in Al-Dakhliyah between 2008 and 200 were reviewed. Data covered socio-demographic characteristics, medical and nutrition evaluation and the assessment of mental status and functional abilities. Logistic regression analyses were used to identify the significant determinants of ADL and IADL at the 5% level. Results:The study included 86 elderly aged between 60 and 94 years. More elderly were dependent on IADL (56.12%) than ADL (25.17%). Depression and dementia were more frequent among the elderly dependent on ADL (32.57% and 43.63%) than those dependent on IADL (21.30% and 33.83%). Dependency on IADL was predicted by age, unfavorable socioeconomic status, stroke with residual deficits, use of aid, joint problems, dementia and incontinence. Age, stroke with residual deficits, poor perception of health, physical inactivity, corneal opacity, hearing defect, dementia, depression, incontinence, the use of aid and mobility restriction predicted dependency on ADL. Conclusion: Deterioration of functional abilities among healthy elderly is inevitable because of theadvance in age. Prevention and management of depression, dementia and musculoskeletal disorders and improvement of socioeconomic status may reduce the rates of dependency. ABSTRACT Background: Oxidative stress is characterized by an increased concentration of O 2 -derived products that provoke critical, even irreversible, cell injury. In diabetes mellitus, oxidative stress results both from exposure to hyperglycaemia and from functional limitation of the hexose monophosphate shunt. Aim: Assess relationship between glycaemic control and oxidative stress in elderly diabetic patients. Methodology: Cross sectional study, Ain Shams University, 82 subjects > 50 years, full clinical assessment, FBS (fasting blood sugar), 2 hour PP (post prandial), glycated hemoglobin (HbA1c), TAC (total antioxidant capacity), MDA (malonyldialdehyde ) measured.Results: Patients with nephropathy have higher levels of MDA and lower levels of TAC. Patients with neuropathy and retinopathy have higher levels of MDA than those without (statistically not significant). There was a slightly negative correlation between FBS, HBA1C and TAC and slightly positive correlation between MDA and FBS, HBAC. MDA showed a slightly negative correlation with TAC. Patients on insulin therapy have the higher level of MDA and the lower level of TAC in comparison to the other two groups (not statistically significant). Conclusion: In elderly diabetic patients oxidative stress is highest in those suffering from nephropathy. ABSTRACTBangladesh is one of the poorest densely populated least developed countries in the world, having about 0 million older people...

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Rates and Determinants of Functional Limitations among the Elderly Population in Al-Dakhlyia Region , Sultanate of Oman

Al-Sabahi¹,

Sinawi²,

Al-Hinai³

2013

MEJAA

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“…Peran vitamin C yaitu mengurangi toksisitas glukosa yang berkontribusi mencegah terjadinya penurunan massa sel B dan kadar insulin dalam tubuh (Winarsi, 2013). Mekanisme vitamin C dalam menurunkan kadar glukosa darah yaitu menginhibisi proses autooksidasi glukosa, dimana struktur vitamin C yang mirip dengan glukosa berkompetisi untuk mencegah autooksidasi glukosa menjadi sorbitol (Doupis et al, 2007).…”

Section: Pendahuluanunclassified

“…Kemampuan vitamin C bentuk tereduksi maupun teroksidasi dapat menghambat masuknya glukosa GLUT transporter ke dalam sel sehingga mampu mengurangi gangguan vasodilatasi tergantung sel endotel. Vitamin C juga menghambat autooksidasi glukosa, dimana struktur vitamin C yang mirip dengan glukosa sehingga berkompetisi dengan glukosa mencegah autooksidasi glukosa menjadi sorbitol yang berbahaya bagi penderita diabetes (Doupis et al, 2007).…”

Section: Hasil Penelitianunclassified

The Effect of Belimbing Wuluh (Averrhoa Bilimbi L.) and Red Guava (Psidium Guajava L.) Extract on Fasting Blood Glucose Levels of Diabetic Wistar Rats Model

Warisman¹,

Suryana²,

Olivia³

2019

AMS

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Diabetes mellitus is a metabolic disease with special characteristic which increased blood glucose level (hiperglicemic), its happens because of the abnormality of insulin secretion, insulin mechanisme or both of them. Belimbing wuluh and red guava extract can become alternative functional drink that contain rich of vitamin C to help controlling blood glucose level. The aimed of this study was to determined the effect of belimbing wuluh and red guava extract on blood glucose levels of Rattus novergicus strain Wistar diabetic model. This research was an true experimental study with a randomized post-test control group design. Twentyfour (24) male wistar strain rats weighing 200-250 grams, aged 2-3 months, were divided into 4 groups. The control group (K-) non-diabetic rats, the control group (K+) diabetic rats given standard diet, and the treatment group diabetic rats given standard diet and belimbing wuluh and red guava extract intervetion doses 10,7 ml/day (P1) and 21ml/day (P2). Measurement of pretest posttest fasting blood glucose levels was carried out using biolyzer. The data were analyzed by One Way Anova test. The results showed that there were significant differences in delta pretest and posttest fasting blood glucose levels between all groups. Blood glucose levels decreased at 55.6%. In conclusion, belimbing wuluh and red guava extract 21ml/day most effectively decreased fasting blood glucose levels in diabetic wistar rats moldel. Keywords: belimbing wuluh, blood glucose level, diabetes mellitus, red guava

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“…Co-morbid anxiety disorders are frequent in diabetes patients and include generalized anxiety condition, posttraumatic stress status, and panic disorder [ 7 ]. With the initial diagnosis of diabetes and with the first onset of diabetes complications, anxiety disorders increase among diabetic patients [ 8 ]. Diabetes and psychological illnesses, such as anxiety and depression, may be correlated in a bidirectional manner, with one condition raising the risk of the other [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Significance of Disease Knowledge as a Risk Factor for Depression and Anxiety in Diabetic Patients

El-Tantawy,

AlZhrany,

ALZahrani

et al. 2024

JLM

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Background Diabetes mellitus is a chronic disease that can lead to depression and anxiety disorders if it is not controlled and managed properly. This study aimed to estimate the prevalence of depression and anxiety disorders among diabetic patients and to determine whether patient knowledge is a risk factor. Methods The study included 220 patients with diabetes who attended the Diabetic Care Center. Socio-demographic data on the patients was collected. The Hospital Anxiety and Depression Scale questionnaire was used to assess patients’ depression and anxiety levels. The Diabetes Knowledge Test 2 was used to assess the patients’ knowledge of diabetes. Results From 220 patients with diabetes, anxiety was detected in 78.2%. From the recordings of these patients with diabetes, it was observed that 32.7%, 29.5%, and 15.9% suffered from mild, moderate, and severe anxiety, respectively. Depression was diagnosed in 170 patients (77.2%), with the majority sowing a moderate degree (32.3%) of depression. Furthermore, 29.5% and 15.5% patients had recorded mild and severe degrees of depression, respectively. Patients’ understanding of diabetes was inadequate in this study, with the majority of patients (70.5%) having a low level of overall diabetes knowledge. In terms of general knowledge of diabetes, 64.1% patients had a low knowledge level, whereas 74.5% patients had a low knowledge level related to insulin therapy. Conclusion The patients’ diabetes knowledge is significantly correlated with their anxiety and depression symptoms. Patients with diabetes should be regularly screened for anxiety and depression symptoms. Our findings indicate that the educational diabetes program could be a useful intervention for reducing depression and anxiety.

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Antioxidants, Diabetes, and Endothelial Dysfunction

Cited by 4 publications

References 64 publications

Rates and Determinants of Functional Limitations among the Elderly Population in Al-Dakhlyia Region , Sultanate of Oman

Rates and Determinants of Functional Limitations among the Elderly Population in Al-Dakhlyia Region , Sultanate of Oman

The Effect of Belimbing Wuluh (Averrhoa Bilimbi L.) and Red Guava (Psidium Guajava L.) Extract on Fasting Blood Glucose Levels of Diabetic Wistar Rats Model

The Significance of Disease Knowledge as a Risk Factor for Depression and Anxiety in Diabetic Patients

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