Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency

Cavalcante, Isa Gabriela de Medeiros; Silva, Alexandre; Costa, Maria J.; Persuhn, Darlene Camati; Issa, Chahira Taha Mahd Ibrahim; Freire, Tiago Lima de Luna; Gonçalves, Maria da Conceição Rodrigues

doi:10.1016/j.exger.2015.03.011

Cited by 81 publications

(42 citation statements)

References 51 publications

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“…In another study, Zhang et al [39] observed significant increases in TAC and GSH levels following the intake of high-dose vitamin D (50,000 IU every 2 weeks) for 12.5 days among women with gestational diabetes. Vitamin D supplementation at a dosage of 200,000 IU for 4 weeks also reduced inflammatory markers and increased TAC levels in elderly women with vitamin D insufficiency [40]. However, a meta-analysis study conducted by Jamka et al [41] reported that vitamin D supplementation had no significant effect on inflammatory biomarkers in obese and overweight subjects.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2018

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Objective: This study was conducted to evaluate the effects of vitamin D supplementation on the recurrence and metabolic status of patients with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3). Methods: This randomized, double-blind, placebo-controlled trial was carried out among 58 women diagnosed with CIN2/3. Participants were randomly assigned into 2 groups to receive either 50,000 IU vitamin D3 (n = 29) or placebo (n = 29) every 2 weeks for 6 months. Results: The recurrence rate of CIN1/2/3 was 18.5 and 48.1% in the vitamin D and placebo groups respectively (p = 0.02). When we excluded CIN1, the recurrence rate of CIN2/3 became nonsignificant. Vitamin D supplementation significantly decreased fasting plasma glucose (–7.8 ± 9.2 vs. –1.1 ± 8.6 mg/dL, p = 0.006) and insulin levels (–3.2 ± 4.8 vs. –0.9 ± 3.4 µIU/mL, p = 0.03), and significantly increased quantitative insulin sensitivity check index (0.01 ± 0.02 vs. 0.002 ± 0.01, p = 0.02) compared with the placebo. Additionally, there was a significant decrease in high-sensitivity C-reactive protein (–815.3 ± 1,786.2 vs. 717.5 ± 1,827.3 ng/mL, p = 0.002) and a significant increase in total antioxidant capacity (113.4 ± 137.4 vs. –53.7 ± 186.7 mmol/L, p < 0.001) following the supplementation of vitamin D compared with the placebo. Conclusions: Vitamin D3 supplementation for 6 months among women with CIN2/3 had beneficial effects on CIN1/2/3 recurrence and metabolic status; however, it did not affect CIN2/3 recurrence.

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Section: Discussionmentioning

confidence: 99%

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2018

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“…Epidemiological studies show correlations between low serum 25(OH)D concentrations and increased insulin resistance, as well as impaired β-cells function (45) and T2D risk (46)(47)(48). While, some studies have shown that vitamin D supplementation improves insulin sensitivity (49), and reduces inflammation biomarkers as CRP, TNF, IL6 and IL8 after vitamin D supplementation (50)(51)(52)(53). Our data corroborate these findings and also demonstrate the association between high levels of systemic inflammatory cytokines and insulin resistance among obese Saudi type 2 diabetic with vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 99%

Association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency

Al-Sharif

2016

Electron J Gen Med

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Background: Vitamin D deficiency is now considered a public health problem around the world that is strongly associated with all-cause and cardiovascular mortality. However, vitamin D deficiency may play a role in mediating low-grade inflammation and insulin resistance among type 2 diabetic patients. Objective: The aim of the present study was to investigate the possible relationship between inflammation, insulin resistance among obese Saudi type 2 diabetic with vitamin D deficiency. Materials and Methods: One hundred obese Saudi patients with T2DM (60 males and 40 females). Their age was46.38 ± 7.53 year, and a control group included one hundred healthy volunteers, who was gender and age matched. Results: Obese T2DM patients showed significantly higher glucose, insulin, glycosylated hemoglobin (HBA1c), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C-reactive protein(CRP) in addition to significantly lower values of the quantitative insulinsensitivity check index (QUICKI) and 25(OH) vitamin D levels in comparison to controls. Serum levels of TNF-α , IL-6 and CRP showed an inverse relationship with QUICKI and a direct relationship with HOM-IR and HBA1c among obese Saudi type 2 diabetic with vitamin D deficiency. Conclusion: Within the limit of there is an association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency.

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“…118 VD is a potent antioxidant, 119,120 and research indicates that lower levels of VD are associated with increased OS. 121 VD supplementation attenuates OS 122,123 and evidence indicates that OS plays a role in VD metabolism. 124 All these point the fact that VD deficiency promotes elevated OS and MtD in MS and OS and MtD might be the underlying mechanism of VD's role in MS.…”

Section: Vitamin D (Vd)mentioning

confidence: 99%

On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

Tobore

2019

Neurology & Clinical Neurosc

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Multiple sclerosis (MS) is a complex human neurodegenerative dysimmune disease of the central nervous system (CNS) which is characterized by chronic inflammation, demyelination, loss of blood‐brain barrier (BBB) integrity, neuronal loss, reactive astrogliosis, and oligodendrocyte depletion. It can result in physical disability and severe neurological and cognitive deficits. Research indicates that MS prevalence has significantly increased in many regions around the world since 1990. The specific elements that trigger MS remain unknown. In this paper, the critical role played by mitochondria dysfunction and oxidative stress in MS pathogenesis, progression, and clinical symptoms are elucidated. Their interactions with the key factors in the disease, as well as treatment strategies, are discussed.

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Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency

Cited by 81 publications

References 51 publications

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

Long-Term Vitamin D Supplementation and the Effects on Recurrence and Metabolic Status of Cervical Intraepithelial Neoplasia Grade 2 or 3: A Randomized, Double-Blind, Placebo-Controlled Trial

Association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency

On elucidation of the role of mitochondria dysfunction and oxidative stress in multiple sclerosis

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