Association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency

Al-Sharif, Fadwa M.

doi:10.29333/ejgm/81757

Cited by 3 publications

(4 citation statements)

References 62 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cytokines have the ability to bind to cell membrane receptors, causing inflammation and exacerbating glucose intolerance. 37 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

Abdulfattah

2023

Health Science Reports

View full text Add to dashboard Cite

Background and aim Urinary tract infection (UTI) is the most common infection in type 2 diabetes patients. TNF‐β is a cytokine with multiple functions in immunomodulatory and inflammatory mechanisms. The variation at position +252 A/G of TNF‐β impacts both gene expression and plasma concentration of TNF‐β proteins. The findings may shed light on the genetic factors that predispose diabetic patients in Iraq to UTIs. Methods A total of 200 individuals were divided into 100 patients with type 2 diabetes, categorized according to UTI, and 100 control subjects. Genetic analysis of +252 A/G of the TNF‐β gene was carried out using the TaqMan probe allele discrimination method. The level of TNF‐β was estimated by the ELISA technique. Results In the recessive model (GG vs. AA/AG) of TNF‐β + 252 A/G in T2D/UTI patients compared to controls, a significant association p = 0.029 (OR: 2.8; CI 95% = 1.14–7.09): E = 15.6% was observed. Furthermore, in T2D patients without UTI, the dominant model AA versus AG/GG was associated with a preventive role P: 31.3% (OR: 0.4; CI 95% = 0.22–0.88) and a p value = (0.02). Overall, AG proportions showed a high level of TNF‐β within the control group p = 0.03, while all proportions of the +252 A/G showed significant differences in TNF‐β level between groups p ≤ 0.05. Pearson's correlation analysis observed a link between TNF‐ levels, fasting plasma glucose (FPG), and HbA1c. Conclusion In T2D patients, the G allele may be linked to a higher probability of UTI, as well as an increased level of TNF‐β in a genotype‐dependent manner.

show abstract

“…These cytokines have the ability to bind to cell membrane receptors, causing inflammation and exacerbating glucose intolerance. 37 …”

Section: Discussionmentioning

confidence: 99%

“…There is convincing evidence that inflammatory processes obstruct basal metabolism and disrupt insulin signaling, resulting in higher expression of pro‐inflammatory cytokines. These cytokines have the ability to bind to cell membrane receptors, causing inflammation and exacerbating glucose intolerance 37 …”

Section: Discussionmentioning

confidence: 99%

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

Abdulfattah

2023

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…Al-Sharif [19] expressed that IR by estimated HOMA and QUICKI strategies were found in the scope of 87.5 to 90% of patients with type 2 DM and 12.5 to 22.5% of control gathering.…”

Section: Discussionmentioning

confidence: 99%

Study of FTO Gene Polymorphism Association with Type 2 Diabetes and Increasing BMI in Egyptian Patients

Sabry¹,

Ibrahim²,

Fadeel³

et al. 2020

Benha Journal of Applied Sciences

View full text Add to dashboard Cite

The aim of this study is to demonstrate the association of the fat-mass and obesity associated gene (FTO) polymorphisms with type 2 diabetes (T2D) and the various aspects of BMI in Egyptian patients. FTO quality polymorphism was distinguished utilizing PCR-RFLP in 40 patients with type 2 diabetes mellitus (DM) and 40 evidently sound control subjects. All members were exposed to clinical assessment including estimating systolic and diastolic circulatory strain, BMI, midsection perimeter (WC), neck circuit (NC) and abdomen hip proportion (WHR) and evaluation of both quantitative insulin affectability check record (QUICKI) and HOMA-IR. People with AA genotype were 6.8 occasions bound to have DM than TT genotype patients. T allele was viewed as a defensive factor while An allele was a free hazard factor for T2DM. AA and AT genotypes are noteworthy indicators of type 2 diabetes mellitus. There was noteworthy increment in BMI, NC, WHR (in females) and WC (in guys) in AA genotype bunch contrasted with TT and AT genotype gatherings. HOMA-IR was distinguished higher in AA genotype bunch contrasted with TT and AT genotype gatherings. An allel of (FTO rs9939609) quality polymorphism was seen as altogether connected with expanded danger of T2D and expanded BMI in Egyptian patients.

show abstract

“…The loss of the eyesight or the whole eye significantly worsens the quality of life of a pet and becomes an urgent issue for the pet owner. In such cases, depending on the character and severity of the disease, penetrating keratoplasty can be used for the treatment (Pavlova, 2013;Al-Sharif, 2016).…”

Section: Introductionmentioning

confidence: 99%

Penetrating Keratoplasty with a Preserved Donor Cornea in Veterinary Ophthalmology

Usha¹,

Kontsevaya²,

Lutsay³

et al. 2019

JMBR

View full text Add to dashboard Cite

The present article describes the penetrating keratoplasty using the technique of rehydration of donor cornea dehydrated over silica gel, as well as complications that can arise. The indications included corneal ulcers, descemetocoele, corneal sequestrum and corneal perforation. 37 (88.37%) out of 43 corneal transplants had a favorable outcome in surgeries with complete excision of abnormal tissues. In 5 cases (11.63%), the authors faced such complications as suture failure, formation of anterior synechias, incomplete epithelization after the suture removal, and transplant swelling reversed with the preservation of eye optical functions, and secondary glaucoma in the late postoperative period that ended up in eyeball endoprosthesis transplantation. Due to a high rate of efficiency of the proposed method, penetrating keratoplasty with rehydrated grafts can be recommended for the treatment in case of medical emergency experienced by cats and dogs.

show abstract

Association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency

Cited by 3 publications

References 62 publications

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

The etiological effect and genetic risk of +252 A/G variant of TNF‐β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study

Study of FTO Gene Polymorphism Association with Type 2 Diabetes and Increasing BMI in Egyptian Patients

Penetrating Keratoplasty with a Preserved Donor Cornea in Veterinary Ophthalmology

Contact Info

Product

Resources

About