Effect of Vitamin C Supplementation on Blood Lead Level, Oxidative Stress and Antioxidant Status of Battery Manufacturing Workers of Western Maharashtra, India

Ghanwat, Ganesh H.; Patil, Arun T.; Kshirsagar, Mandakini S; Sontakke, Ajit; Ayachit, Ram Krishna

doi:10.7860/jcdr/2016/15968.7528

Cited by 13 publications

(14 citation statements)

References 27 publications

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“…Additionally, the presence of vitamin c in lemon juice supported the protective effect of lemon juice either alone or with flaxseed protein isolate against the negative effects of lead acetate on liver and kidney which reflected through the results of the current study. It has been declared in several studies that vitamin c diminished the lead toxicity may be due to its antioxidant activity or its ability as a chelator of lead [46,47]. Moreover, there are other bioactive compounds in lemon juice to which the beneficial effect of lemon juice may be attributed such as naringenin (polyphenol, 4,5,7-trihydroxy-flavanone) that present in lemon juice by 0.38 mg/100 ml [48].…”

Section: Discussionmentioning

confidence: 99%

Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats

2020

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Section: Discussionmentioning

confidence: 99%

Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats

2020

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“…To investigate if a high dose daily supplementation with ascorbic acid can reduce elevated lead levels in the different portions of hen eggs, hens in G1 received ascorbic acid (500 mg/kg body weight /day) mixed with water and feedstuff on daily basis for 4 weeks. The decision to use this dose was informed by previous studies in which ascorbic acid was investigated in the management of lead intoxication [36,37]. Eggs laid during this period were collected, labeled, and stored separately in suitable plastic transparent bags at 4°C until the time of preparation for analysis.…”

Section: Control and Treatment Groupsmentioning

confidence: 99%

Sub-chronic treatment with high doses of ascorbic acid reduces lead levels in hen eggs intentionally exposed to a concentrated source of lead: a pilot study

Shawahna

Zyoud

Yahia

et al. 2020

BMC Pharmacol Toxicol

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Background: Hen eggs contaminated with lead can be harmful to the health of children and adults. The objective of this pilot study was to investigate if sub-chronic treatment with ascorbic acid can reduce lead levels in the different parts of hen eggs after intentionally exposing the laying hens to a concentrated source of lead. Methods: Clinically normal mixed-breed egg laying hens (n = 18) were used in this pilot study. Hens were exposed to a concentrated source of lead (200 mg/kg body weight /day lead acetate) for 1 week. Subsequently, egg laying hens were either treated with sub-chronic doses of ascorbic acid (500 mg/kg body weight /day) or left untreated for 4 weeks. Lead levels were assessed in eggshell , egg-albumen, and egg-yolk samples using a graphite furnace atomic absorption spectrophotometer. Results: Lead levels increased significantly (p-value < 0.01) from baseline in egg-yolk, egg-albumen, and eggshell samples following 1 week exposure to lead acetate. Sub-chronic treatment of egg laying hens with high doses of ascorbic acid could bring statistically significant reduction (p-value < 0.01) in lead levels in egg-yolk, egg-albumen, and eggshell samples after intentional exposure to a concentrated source of lead. Conclusions: Findings of this pilot study showed that sub-chronic treatment of egg laying hens with ascorbic acid can reduce lead levels in different egg parts after intentional exposure to a concentrated source of lead. Supplementing feedstuffs and water with sources of ascorbic acid could be beneficial in reducing lead levels in hen egg tissues following environmental exposure. Further studies are still required to investigate if ascorbic acid can reduce lead levels in other chicken tissues.

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“…In developing countries, heavy metals pollution is one of the serious problems and public awareness of their toxic effects is increasing (Qu et al, 2012). Occupational exposure is one of the most important sources of exposure to lead (Conterato et al, 2013;Ghanwat et al, 2016;Hsieh et al, 2017). The lead enter to the workers' body through the inhalation route, and then can accumulate in the vital organs of the body (Ghanwat et al, 2016;Hsieh et al, 2017;Kalahasthi and Barman, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Occupational exposure is one of the most important sources of exposure to lead (Conterato et al, 2013;Ghanwat et al, 2016;Hsieh et al, 2017). The lead enter to the workers' body through the inhalation route, and then can accumulate in the vital organs of the body (Ghanwat et al, 2016;Hsieh et al, 2017;Kalahasthi and Barman, 2018). Inhalation, skin and ingestion are among the most important routes of exposure to zinc.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure in lead and zinc mines induces oxidative stress in miners lymphocytes: Role of mitochondrial/lysosomal damage

Seydi

Soltani

Ramazani

et al. 2020

Main Group Metal Chemistry

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The purpose of this research was to determine mitochondrial and lysosomal damage and oxidative stress status in blood lymphocytes of lead-zinc miners. This research was performed in 10 mine workers who have been in contact with lead and zinc in comparison to a control group containing 10 healthy volunteers. Lymphocytes were isolated from peripheral blood using the Ficoll standard method and then mitochondrial and lysosomal damage and oxidative stress were evaluated. The level of reactive oxygen species (ROS), collapse in the mitochondrial membrane potential (MMP) collapse, and glutathione disulfide (GSSG) content, and lysosomal damage in miners were higher than the control group. Also, viability and glutathione (GSH) content were decreased. The lymphocytes of workers of a lead-zinc mine are more susceptible to oxidative stress, mitochondrial and lysosomal damage. The proper use of safety equipment can reduce the risk of toxic agents and their subsequent hazards for mine workers.

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Effect of Vitamin C Supplementation on Blood Lead Level, Oxidative Stress and Antioxidant Status of Battery Manufacturing Workers of Western Maharashtra, India

Cited by 13 publications

References 27 publications

Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats

Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats

Sub-chronic treatment with high doses of ascorbic acid reduces lead levels in hen eggs intentionally exposed to a concentrated source of lead: a pilot study

Occupational exposure in lead and zinc mines induces oxidative stress in miners lymphocytes: Role of mitochondrial/lysosomal damage

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