Effect of use of platelet rich plasma on post-breeding uterine inflammatory response of mares

Clinical and Histopathological Evaluation of Using Platelet-Rich Plasma and Platelet-Rich Fibrin Matrix in Treatment of Induced Chronic Open Wounds in Bucks

“…In both treated groups, the physiological parameters were in normal values (body temperature, appetite, heart, and respiratory rate) during study period, this result agrees with Kim et al and Reghini et al [9,23]. This result of two groups demonstrated that applying PRP and PRF matrix to chronic wound resulted in a significant healing effect, which may be related to platelets role in wound healing in hemostasis and initiation of wound healing, after platelet activation and clot formation, growth factors are released from α-granules including PDGF, bTGF-b, VEGF, FGF, IGF, and EGF and bioactive factors such as serotonin, histamine, dopamine, calcium, and adenosine are also stored in these dense granules these growth factors work as biologic mediators to promote cellular activity by binding to specific cell surface receptors [24,25].…”

Inflammatory mechanisms of endometritis

“…The use of plasma is starting to regain attention by clinicians and researchers in the form of platelet rich plasma (PRP). Some preliminary reports suggest that treatment with PRP improves the outcome of subfertile mares ; however, more research with controlled studies is warranted. Another evolving treatment for endometritis and endometrial degeneration is the use of stem cells, and researchers are investigating stem cells as a potential treatment for uterine degeneration.…”

Global view on the problem of 'thin' endometrium: solutions to the problem in assisted reproductive technology (literature review)

“…В итоге восстанавливаются обменные процессы, улучшаются микроциркуляция и метаболизм в клетках тканей, нормализуется тканевое дыхание, активизируется местный иммунитет, запуская все звенья естественных процессов регенерации одновременно и действуя на них синергетически [35]. Следовательно, благодаря компонентам плазмы, проявляются биологические эффекты, направленные на стимуляцию клеточных механизмов: ангиогенез, хемотаксис макрофагов, пролиферацию и миграцию фибробластов, синтез коллагена, эластина, остеобластов, межклеточного вещества, эндотелиальных клеток [36]. Клинически доказаны обезболивающий, противовоспалительный, иммуномодулирующий, иммуностимулирующий, антибактериальный эффекты аутоплазмы [37].…”