Effect of Tualang honey on the anastomotic wound healing in large bowel anastomosis in rats-A randomized controlled trial

Abstract

BackgroundHoney has long been used for the treatment of number of ailments and diseases including surgical wounds. Current study evaluates the effectiveness of Tualang honey (TH) for large bowel anastomotic healing in Wistar rats.MethodsThirty male Wistar rats were given a 3 centimeter infra-umbilical laparotomy wound, in`flicted on their abdomen. The colonic transection was performed at 5 cm distal to caecum, with end to end anastomosis of colon segment. They were divided into two groups. Group I was fed with standard rat chow and water. Meanwhile, Group II apart from standard feed, was also given TH 1.0 g/kg every morning until day seven post operatively. Afterwards, anastomotic bursting pressures were measured and histopathological examination on the anastomosis line was performed with light microscopes. The data from two groups were analyzed by Independent paired t test for continuous variables.ResultsIt was found that the tensile strength of colon anastomosis (95 % CI; p = <0.001) and the histopathological study including fibroblast count (p = <0.001) and inflammatory cells (p = 0.002) showed statistically significant difference in the favor of TH-treated group. Meanwhile, neovascularization formation was not statistically significant (p = 0.807); however, the overall count in the TH group was high.ConclusionOral treatment with TH enhances anastomotic wound healing by increasing the number of fibroblasts and by decreasing inflammatory cells leading towards increased wound strength.

Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review

“…A study by Sukur et al (2011) showed that topical application of Tualang honey on burn wounds contaminated with P. aeruginosa and A. baumannii provided a faster healing rate than chitosan gel or hydrofibre silver treatment [ 124 ]. Meanwhile, another study showed that the oral treatment of Tualang honey enhanced anastomotic wound healing in large bowel anastomosis in rats by increasing the number of fibroblasts and decreasing inflammatory cells, leading to increased wound strength [ 125 ]. A clinical trial looking into Tualang honey’s effect on promoting the post-tonsillectomy healing process has been conducted by comparing sultamicillin-treated group and sultamicillin + Tualang honey-treated group.…”

Comparison of Honey versus Polylactide Anti-Adhesion Barrier on Peritoneal Adhesion and Healing of Colon Anastomosis in Rabbits

“…Bowel anastomosis is a common abdominal operation, and the incidence of anastomosis leakage has been reported in different studies between 2.6% to 30% depending on the type of procedure, surgical technique and patient demographics [8], [9], [10], [11]. Anastomosis leakage leads to increase hospitalisation, morbidity and mortality ranging from 6.2% to 37% [12], [13].…”

Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

“…Honey possesses many beneficial properties such as neuroprotective, anti-oxidative, anti-inflammatory, antibacterial, wound healing, anticancer etc. [5,6,13,14]. Based on the current literature search, there has been very little research on the effect of honey on learning and memory on chronic cerebral hypoperfusion induced neurodegeneration in animal models.…”