Introduction Peritoneal antibiotic or normal saline lavage is seen to be beneficial in order to reduce the pain or infection risk through laparoscopic surgeries. It can also be applied for laparoscopic colectomy surgeries. In this study, we have compared the effects of antibiotic solution lavage (gentamycin-clindamycin) with normal saline lavage in patients undergoing laparoscopic colectomy surgery. Method In this double-blind Randomized Controlled Trial (RCT), 40 patients undergoing laparoscopic colectomy surgery were divided into antibiotic and normal saline lavage groups (20 patients in each group). Post-operational pain, need for painkiller, white blood cells count, C-reactive protein level, duration of hospitalization and wound infection were compared in 30 days between the groups. Results Antibiotic lavage group had significantly less pain than the normal saline group (p < 0.05) through 3, 6, 12 and 24 h after surgery. C-reactive protein level, white blood cells count, painkiller use, and hospitalization duration were significantly lower in antibiotic group. However, there was no difference regarding wound or intra-abdominal infection between the both groups. Conclusion Using gentamicin-clindamycin peritonea lavage helps patients undergoing laparoscopic colectomy surgery in pain reduction, need for painkillers and hospitalization duration.
Background: Given the importance of patients’ pain after laparoscopic surgeries, this study was conducted to compare the effectiveness of intraperitoneal bupivacaine, acetazolamide, and placebo on pain relief after laparoscopic cholecystectomy surgery. Methods: Patients admitted to Rasool Akram hospital with physical status I or II, based on the American Society of Anesthesiologists (ASA) system, who were candidates for laparoscopic cholecystectomy surgery due to gallstones, were included in this study. Patients were divided into 3 groups (each group containing 20 patients) using block randomization with foursome blocks. Group 1 received bupivacaine, group 2 acetazolamide, and group 3 intravenous saline as placebo. After surgery, pain score was assessed by visual analogue scale, and shoulder pain and analgesic doses were also measured. The mentioned parameters were assessed at 1, 4, 8, 12, and 24 hours after surgery. Results: In this study, 60 patients were included in 3 groups. The mean pain recorded (VAS) at 1, 4, and 8 hours after surgery was not significantly different between acetazolamide and bupivacaine groups, but their score was significantly lower than the placebo group (p<0.05). However, the score recorded at 12 and 24 hours after surgery was not significantly different between the 3 groups (p>0.05). Mean of pain reliever (acetaminophen) injected to the patients when needed was not significantly different among the 3 intervention groups (p<0.05). The highest prevalence of shoulder pain (70%) belonged to the placebo group and the lowest (25%) to acetazolamide (p<0.05). Mean heart rate, systolic blood pressure, diastolic blood pressure, and the respiratory rate were not significantly different among intervention groups in 1, 4, 8, 12, and 24 hours after surgery (p>0.05). Conclusion: According to the results, acetazolamide and bupivacaine injection reduced pain in early hours after laparoscopy. However, pain intensity was not different between intervention groups and the control group after 12 hours, so re-prescription seems to be appropriate at this time. Acetazolamide injection significantly reduces shoulder pains after surgery.
Introduction: Due to wide clinical differences in various pathological types of breast cancer and also close association between disease prognosis and molecular subtypes of the tumor, it has been recently suggested a relationship between traditional risk factors and molecular subtypes of breast cancer. Hence, the present study aimed to assess the association of reproductive risk factors for breast cancer with tumor molecular subtypes. Materials and Methods:This bi-center cross-sectional study was performed on 800 consecutive women with known breast cancer who referred to two great referral hospitals as the Comprehensive Cancer Centers in Tehran between 2006 and 2016. The baseline information related to reproductive risk profiles as well as pathological tumor diagnosis and molecular subtypes determined using immune-histochemical analysis by immune-staining for ER, PR, and HER2 molecules were collected by reviewing the hospital recorded files. Results: Of 800 samples included for immune-histochemical analysis, 314 (39.3%) were positive for Luminal A subtype, 107 (13.4%) for Luminal B subtype, 153 (19.1%) for HER-2 over expression, and 226 (28.3%) for triple negative subtype. Among all reproductive risk factors initially assessed, young age was associated with HER-2 over expression pattern, more tumor size with luminal B subtype, lower age at pregnancy with luminal A subtype, lower number of gravid with triple negative pattern, the history of abortion with luminal B subtype, and shorter duration of breastfeeding with triple negative subtypes. Conclusions: Each molecular subtype of breast cancer in our population can be specifically associated with specific reproductive risk factors.
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