Comparison of Honey versus Polylactide Anti-Adhesion Barrier on Peritoneal Adhesion and Healing of Colon Anastomosis in Rabbits

Abstract

BACKGROUND: Postoperative adhesion is still a consequence of intra-abdominal surgeries, which results in bowel obstruction and abdominopelvic pain. Bowel anastomosis as a common abdominal surgery has the incidence of leakage in up to 30% of patients that increase morbidity and mortality. Due to similar pathways of adhesion formation and wound healing, it is important to find a way to reduce adhesions and anastomosis leakage.
 AIM: This study was designed to compare antiadhesive as well as anastomosis healing improvement effect of honey and polylactide anti-adhesive barrier film.
 METHODS: Forty-five rabbits divided into three groups of honey, adhesion barrier film, and control group in an animal study. Under a similar condition, rabbits underwent resection and anastomosis of cecum under general anaesthesia. In the first group, honey was used at the anastomosis site, in the second one polylactide adhesion barrier film utilised, and the third one was the control group. Adhesion, as well as anastomosis leakage, was assessed after 21 days. Data were analysed using the Statistical Package for Social Scientists (SPSS) for Windows version 25.
 RESULTS: Three groups of 15 rabbits were studied. The results showed that mean peritoneal adhesion score (PAS) was lower in the honey group (1.67) in comparison to the adhesion barrier film group (3.40) and the control group (6.33).
 CONCLUSION: Bio-absorbable polylactide barrier has an anti-adhesion effect but is not suitable for intestinal anastomosis in rabbits. Further studies needed to evaluate these effects on human beings.

Efficacy of pectin-honey hydrogel and vitamin E in prevention of post-surgical intraperitoneal adhesions in rabbits

“…_____________________ intraperitoneal pectin-honey hydrogel group, significantly lower adhesion score might be due to the barrier action of honey that effectively separate traumatised surfaces after surgical manipulation and reduce the extent as well as severity of adhesion. Similar observation also recorded by Saber (2010); Negahi et al (2019) and Giusto et al (2016) in rabbits and rat model.…”

Comparison of Safety Intraabdominal Antiadhesive Agent Base on Hepatetic Steatosis in Wistar RAT

“…Proses adhesi merupakan suatu proses yang komplek meliputi seluler, biokemikal dan faktor immunologi (Giusto et al, 2016); (Negahi et al, 2019). Keseimbangan antara proses pembentukan fibrin dan fibrinolysis merupakan hal penting dalam proses tersebut.…”